NAPS2 Neuroimaging Core
NAPS2 神经影像核心
基本信息
- 批准号:10674049
- 负责人:
- 金额:$ 53.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAtrophicBrain StemBrain imagingCell NucleusClinicalClinical DataClinical ResearchCollaborationsCollectionCommunitiesConfidentiality of Patient InformationCorpus striatum structureCross-Sectional StudiesDataData CollectionData SetDementia with Lewy BodiesDiffusionDiffusion Magnetic Resonance ImagingDiseaseDisease ProgressionDrug Delivery SystemsEnsureFoundationsFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGeneticGoalsImageImaging DeviceInvestigationIronLaboratoriesLanguageLongitudinal StudiesMagnetic Resonance ImagingMaintenanceMapsMeasurementMeasuresMethodsMonitorMultiple System AtrophyNerve DegenerationNeurodegenerative DisordersOffice of Administrative ManagementOutcomeParasomniasParkinson DiseaseParticipantPatientsPatternPlayPredispositionProcessProtocols documentationQuality ControlREM Sleep Behavior DisorderRadionuclide ImagingReproducibilityResearchResearch PersonnelResolutionResourcesRestRoleScanningSiteStandardizationSubstantia nigra structureSymptomsTechniquesTestingThickTimeUnited States National Institutes of HealthWorkbasal forebrainbiomarker identificationcandidate markercerebral atrophyclinical caredata managementdata sharingdopamine systemexperiencegenetic informationhigh riskimage processingimaging modalityimaging studyinnovationinterestlocus ceruleus structurelongitudinal analysismultimodalityneuroimagingneuroimaging markerneuromelaninneuroprotectionpars compactaprogramsprogression markerprospectivesingle photon emission computed tomographysoundsynucleinopathytargeted biomarkertargeted treatmenttrial designuptakeweb site
项目摘要
ABSTRACT: NAPS2 NEUROIMAGING CORE
The Neuroimaging Core of the North American Prodromal Synucleinopathy Consortium on RBD,
Stage 2 (NAPS2) will ensure that state-of-the-art techniques are applied and that innovative analytic
techniques are used. The Neuroimaging Core will be directed by leaders in brain imaging in
neurodegenerative diseases with extensive experience supporting the imaging needs of multi-site projects.
Many of the Core leaders have collaborated with NAPS investigators on prior research in RBD and
synucleinopathies. The prior experience and collaborations within the Neuroimaging Core team will ensure a
smooth transition of imaging support for NAPS2. Prior imaging studies of RBD are few and have generally
been small, retrospective, or single-site investigations. We provide preliminary data to support all of the
imaging modalities that will be utilized in the protocol and demonstrate the soundness of the methods
proposed. We will prospectively collect and evaluate multimodal MRI and DaTscan imaging data in over 300
participants with RBD longitudinally, at two time points, with innovative methods to support the Project and
advance the field. There are several innovative aspects of this Core, including the use of: 1) multi-shell and
multi-band imaging acquisition protocols for collection of high resolution dMRI and rs-fMRI data in reasonable
acquisition time, harmonized across multiple sites, 2) quantification of iron load with multi-echo gradient echo
(GRE) MRI using quantitative susceptibility mapping and R2* relaxometry, 3) quantification of neuromelanin
volume in locus coeruleus and substantia nigra pars compacta using a magnetization transfer contrast
neuromelanin-sensitive MRI (NM-MRI) approach with automated image processing and high reproducibility,
and 4) DaTscan quantitative analysis using semi-automated processing to provide standardized and
harmonized region-to-background and z-score data. The Neuroimaging Core aims are to: 1) establish and
maintain harmonized MRI and DaTscan SPECT acquisition protocols at the participating sites, 2) operate a
standardized quality control program for MRI and DaTscan, including ongoing image quality monitoring, rating
and maintenance, and 3) supply processed cross-sectional and longitudinal data on serial MRIs and DaTscans
for the Project focused on predicting phenoconversion, and share these data with the research community.
This latter aim includes providing cross-sectional and longitudinal data to the Laboratory of Neuroimaging
(LONI) for sharing with outside investigators. All images will be anonymized and directly downloadable from
the LONI website. Language will be developed on the NAPS2 and LONI websites to guide outside
investigators interested in these data. This clinical dataset will be freely downloadable along with the images
for researchers who do not require genetic information for their analyses.
摘要:naps2神经成像核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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KEJAL KANTARCI其他文献
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{{ truncateString('KEJAL KANTARCI', 18)}}的其他基金
Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy
通过先进的 MR 成像和光谱学了解 COVID-19 对大脑的长期影响
- 批准号:
10307050 - 财政年份:2021
- 资助金额:
$ 53.77万 - 项目类别:
Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy
通过先进的 MR 成像和光谱学了解 COVID-19 对大脑的长期影响
- 批准号:
10712212 - 财政年份:2021
- 资助金额:
$ 53.77万 - 项目类别:
Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy
通过先进的 MR 成像和光谱学了解 COVID-19 对大脑的长期影响
- 批准号:
10445068 - 财政年份:2021
- 资助金额:
$ 53.77万 - 项目类别:
Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy
通过先进的 MR 成像和光谱学了解 COVID-19 对大脑的长期影响
- 批准号:
10649680 - 财政年份:2021
- 资助金额:
$ 53.77万 - 项目类别: