Neuroimaging Core

神经影像核心

• 批准号: 10413838
• 负责人: KEJAL KANTARCI
• 金额: $ 100.52万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413838
• 关键词: African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Autopsy; Award; Biological; Classification; Clinic; Clinical; Clinical Trials; Collaborations; Communities; Complex; Confidentiality of Patient Information; Data; Data Analyses; Dementia; Dementia with Lewy Bodies; Deposition; Development; Diagnosis; Diagnostic; Education and Outreach; Elderly; Enrollment; Faculty; Florida; Frontotemporal Lobar Degenerations; Genetic Risk; Goals; Image; Imaging technology; Impaired cognition; Lead; Light; Magnetic Resonance Imaging; Multimodal Imaging; Nerve Degeneration; Neurodegenerative Disorders; Operations Research; Participant; Pathology; Patients; Positron-Emission Tomography; Procedures; Process; Proteins; Protocols documentation; Quality Control; Race; Research; Research Personnel; Research Project Grants; Resources; Role; Sensitivity and Specificity; Site; Staging; Standardization; Symptoms; Training; Training Support; alpha synuclein; career; catalyst; cerebrovascular lesion; cerebrovascular pathology; cohort; data management; data resource; design; diagnostic criteria; education research; fluorodeoxyglucose positron emission tomography; high resolution imaging; image processing; imaging biomarker; imaging program; imaging study; individual patient; innovation; innovative technologies; multimodal neuroimaging; neuroimaging; neuroimaging marker; neuropathology; next generation; nonalzheimer dementia; outreach; pre-clinical; programs; protein TDP-43; racial diversity; radioligand; recruit; sex risk; single photon emission computed tomography; tau Proteins

PROJECT DESCRIPTION/ABSTRACT – NEUROIMAGING CORE The primary goal of the Neuroimaging Core is to provide imaging biomarker data for diagnostic classification and staging of AD and other dementias, for research projects and clinical trials on ADRC participants, through a harmonized multimodality neuroimaging program at the Mayo Clinic Rochester (MCR) and Mayo Clinic Florida (MCF) sites. A cohort of African American participants from the MCF will be recruited in order to enhance the racial diversity of the multimodality neuroimaging program in the ADRC. The aims of the Neuroimaging Core include: 1) Establishing and maintaining a harmonized MRI, β-amyloid, tau, and FDG PET and DaTScan SPECT imaging program for the Mayo Clinic ADRC, and operating a standardized quality control, image processing and data analysis program for the ADRC cohorts including the African American Cohort in MCF; 2) Support imaging studies and supply imaging biomarker data to the research projects and clinical trials, and the National Alzheimer's Coordinating Center (NACC), while protecting patient confidentiality when sharing high-resolution images; 3) Educating the research community, training, supporting, and enhancing the careers of the next generation of investigators in the aging and dementia neuroimaging biomarkers field. Neuroimaging Core will collaborate with the Clinical Core and the Outreach and Education Core on recruitment of clinically characterized African American participants to imaging studies, with the Neuropathology Core on autopsy confirmation of imaging findings, with the Data Management Core on sharing of the imaging biomarker data with the research community, and with the Research Education Component on training junior faculty. It is expected that the Neuroimaging Core will impact ADRC research operations and National Alzheimer's Coordinating Center (NACC) as an advanced imaging biomarker data resource.

项目说明/摘要-神经成像核心 神经成像核心的主要目标是为诊断提供成像生物标记物数据 AD和其他痴呆的分类和分期，用于ADRC的研究项目和临床试验 参与者，通过梅奥诊所罗切斯特的协调多模式神经成像计划 (MCR)和佛罗里达州梅奥诊所(MCF)网站。来自MCF的一批非裔美国人参与者将是 招募这些人员是为了增强ADRC多模式神经成像方案的种族多样性。 神经成像核心的目标包括： 1)建立和维护协调的磁共振成像、β-淀粉样蛋白、tau和FDGPET和DaTcan 梅奥诊所ADRC的SPECT成像计划，并运行标准化的质量控制， 包括非裔美国人在内的ADRC队列的图像处理和数据分析程序 MCF中的队列； 2)支持影像研究，为研究项目和临床提供影像生物标志物数据 试验和国家阿尔茨海默氏症协调中心(NACC)，同时保护患者 共享高分辨率图像时的保密性； 3)教育研究社区，培训、支持和促进下一代的职业生涯 老龄化和痴呆症神经影像生物标志物领域的一代研究人员。 神经成像核心将与临床核心和外展和教育核心合作 招募具有临床特征的非裔美国人参与者进行成像研究， 神经病理学核心是尸检确认影像发现，数据管理核心是 与研究社区和研究教育共享成像生物标记物数据 关于培训初级教员的组成部分。预计神经成像核心将影响ADRC的研究 美国国家阿尔茨海默病协调中心(NACC)作为先进的影像生物标志物数据 资源。