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Iron and folic acid supplementation strategies during pregnancy and adverse pregnancy outcomes in Botswana

博茨瓦纳妊娠期间铁和叶酸的补充策略和不良妊娠结局

基本信息

批准号：
10674760
负责人：
Ellen Christina Caniglia
金额：
$ 13.27万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10674760
关键词：
Address Adherence Adult Affect African Anemia Area Berry Birth Botswana Cause of Death Child Clinic Clinical Communicable Diseases Communities Computer Simulation Conceptions Country Data Demographic Factors Education Effectiveness Environment Epidemiologic Methods Evaluation First Pregnancy Trimester Folic Acid Formulation Geographic Factor Geographic Locations Gestational Age Goals Guidelines HIV HIV Seronegativity HIV Seropositivity Health Benefit Health system Income Individual Infant Infrastructure International Intervention Intervention Studies Interview Iron Knowledge Link Literature Low Birth Weight Infant Malaria Malnutrition Maternal and Child Health Measures Mentored Research Scientist Development Award Mentors Mentorship Methods Micronutrients Modification Neural Tube Defects Newborn Infant Outcome Pharmaceutical Preparations Policies Population Predisposition Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Proxy Qualitative Evaluations Qualitative Methods Qualitative Research Recommendation Research Research Personnel Research Project Grants Resource-limited setting Resources Risk Risk Factors Sampling Science Sepsis Small for Gestational Age Infant Structure Subgroup Supplementation Time Training Underserved Population Underweight United Nations Woman Work World Health Organization adverse pregnancy outcome antenatal antenatal care career career development compare effectiveness cost effective intervention design experience feasibility testing folic acid supplementation fortification high risk high risk population improved iron deficiency low and middle-income countries maternal weight medical schools prenatal prevent programs research and development side effect stillbirth supply chain surveillance data surveillance study symposium therapy development treatment strategy uptake

项目摘要

PROJECT SUMMARY Background. The risk of stillbirth, preterm delivery, low birthweight and other adverse pregnancy outcomes is extremely high in Sub-Saharan African countries including Botswana, especially among HIV-positive women. Daily iron and folic acid supplementation during pregnancy could reduce adverse pregnancy outcomes by reducing maternal anemia. However, the effectiveness of supplementation in subgroups defined by HIV status, anemia, gestational age, and other clinical, demographic and geographic factors remains unknown and compliance with supplementation guidelines is variable (<50% in Botswana). Cost-effective interventions to provide supplementation to pregnant women in Botswana and other resource-limited settings should be designed to address key barriers to successful supplementation and to reach subgroups that would benefit most from intervention. This K01 provides a unique opportunity to address this gap in the literature. Candidate Overview. My long-term career objective is to become an independent investigator who specializes in interventions to improve maternal and child health in resource-limited settings. My background is in applications of epidemiologic methods to evaluate effects of HIV treatment strategies in adults and infants. A K01 award will provide the necessary additional training and experience needed to become an expert in the design, implementation, and evaluation of interventions to improve pregnancy outcomes in HIV-positive women and underserved populations. Career Development and Training Plan. My education program includes structured course work, professional conferences, directed readings, and a research project with specific aims timed to coincide with these activities. My mentorship team includes international experts who specialize in areas related to my training goals: Dr. Scott Braithwaite (decision science), Dr. Roger Shapiro (HIV and maternal and child health in Botswana), Dr. Donna Shelley (intervention development and implementation), and Dr. Carolyn Berry (qualitative methods). Environment. NYU School of Medicine provides an exceptional environment for me to conduct the proposed study, obtain additional training and mentorship, and successfully transition to an independent investigator. Research Strategy. Using the data and infrastructure from an ongoing birth outcomes surveillance study in Botswana consisting of data from over 130,000 births, my study will: 1) estimate the effect of iron and folic acid supplementation during pregnancy on adverse pregnancy outcomes by HIV status, anemia, gestational age, and other key subgroups to identify populations that would benefit most from intervention; 2) assess barriers to supplementation during and prior to pregnancy; 3) optimize a hypothetical intervention to provide supplementation using computer simulation; and 4) develop and test the feasibility of an intervention to provide supplementation to pregnant women in Botswana.

项目总结

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Assessing knowledge, attitudes, and practices towards causal directed acyclic graphs: a qualitative research project.

DOI：
10.1007/s10654-021-00771-3
发表时间：
2021-07
期刊：
European journal of epidemiology
影响因子：
13.6
作者：
Barnard-Mayers R;Childs E;Corlin L;Caniglia EC;Fox MP;Donnelly JP;Murray EJ
通讯作者：
Murray EJ

A case study and proposal for publishing directed acyclic graphs: The effectiveness of the quadrivalent human papillomavirus vaccine in perinatally HIV Infected girls.

DOI：
10.1016/j.jclinepi.2021.12.028
发表时间：
2022-04
期刊：
Journal of clinical epidemiology
影响因子：
7.2
作者：
Barnard-Mayers R;Kouser H;Cohen JA;Tassiopoulos K;Caniglia EC;Moscicki AB;Campos NG;Caunca MR;Seage GRS;Murray EJ
通讯作者：
Murray EJ

Difference-in-Difference in the Time of Cholera: a Gentle Introduction for Epidemiologists.

霍乱时期的差异之差：流行病学家的温和介绍。

DOI：
10.1007/s40471-020-00245-2
发表时间：
2020-12
期刊：
Current epidemiology reports
影响因子：
3.3
作者：
Caniglia EC;Murray EJ
通讯作者：
Murray EJ

High risk of adverse birth outcomes among adolescents living with HIV in Botswana compared to adult women living with HIV and adolescents without HIV.

DOI：
10.1186/s12884-022-04687-y
发表时间：
2022-04-30
期刊：
BMC PREGNANCY AND CHILDBIRTH
影响因子：
3.1
作者：
Jackson-Gibson, Maya;Zash, Rebecca;Mussa, Aamirah;Caniglia, Ellen C.;Diseko, Modiegi;Mayondi, Gloria;Mabuta, Judith;Morroni, Chelsea;Mmalane, Mompati;Lockman, Shahin;Makhema, Joseph;Shapiro, Roger L.
通讯作者：
Shapiro, Roger L.

Association of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection With Maternal Mortality and Neonatal Birth Outcomes in Botswana by Human Immunodeficiency Virus Status.

根据人类免疫缺陷病毒状况，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染与博茨瓦纳孕产妇死亡率和新生儿出生结果之间的关系。

DOI：
10.1097/aog.0000000000005020
发表时间：
2023
期刊：
Obstetrics and gynecology
影响因子：
7.2
作者：
Jackson-Gibson,Maya;Diseko,Modiegi;Caniglia,EllenC;Mayondi,GloriaK;Mabuta,Judith;Luckett,Rebecca;Moyo,Sikhulile;Lawrence,Pamela;Matshaba,Mogomotsi;Mosepele,Mosepele;Mmalane,Mompati;Banga,Jaspreet;Lockman,Shahin;Makhema,Joseph;
通讯作者：