Utilization of cervical cancer prevention tools and role of high-risk HPV type in the persistent cervical cancer disparities experienced by American Indian/Alaska Native women
宫颈癌预防工具的利用以及高危 HPV 类型在美洲印第安人/阿拉斯加原住民妇女经历的持续性宫颈癌差异中的作用
基本信息
- 批准号:10674523
- 负责人:
- 金额:$ 25.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptedAgeAlaska NativeAmerican IndiansAreaAustraliaAwardBiopsyCenters for Disease Control and Prevention (U.S.)CervicalCervical Cancer ScreeningCervix UteriClinicalColposcopyCommunitiesCountryCoupledCross-Sectional StudiesDataDevelopmentDiagnosisDiscipline of obstetricsDiseaseDisparityDysplasiaEarly treatmentEducational CurriculumEpidemiologyExhibitsFemaleFocus GroupsFoundationsGenderGoalsGynecologyHPV-High RiskHealthHealth PersonnelHeterogeneityHigh PrevalenceHuman Papilloma Virus VaccinationHuman Papilloma Virus VaccineHuman PapillomavirusHuman papillomavirus 16Human papillomavirus 18Immunization ProgramsIncidenceInterventionK-Series Research Career ProgramsLearningLesionMalignant NeoplasmsMalignant neoplasm of cervix uteriMentorsMentorshipMinorityMissionNational Cancer InstituteNational Health and Nutrition Examination SurveyNot Hispanic or LatinoOregonPacific NorthwestPap smearPatientsPlayPopulationPrevalencePreventionPrimary PreventionProceduresPublic HealthPublishingRecommendationReproducibilityResearchResourcesRisk FactorsRoleScienceScientistSmokingSocioeconomic StatusStudy modelsTeacher Professional DevelopmentTimeTime trendTrainingTribesUniversitiesUrban PopulationVaccinatedVaccinationVisionVisualWomanWood materialYouthburden of illnesscancer health disparitycareercervical cancer preventionclinical careclinical research sitedata registrydisparity eliminationexperiencefollow-uphealth disparityhigh riskmalemembermortalitypreventprofessorreservation-basedscreeningsurveillance strategytooltrendtribal organizationvaccine acceptancevaccine efficacy
项目摘要
PROJECT SUMMARY
Dr. Bruegl is an Assistant Professor in the Department of Obstetrics and Gynecology at Oregon Health and
Science University and a national Robert Wood Johnson Foundation Harold Amos Minority Faculty
Development Fellow. Her long-term career goal is to eliminate the disparities in cervical cancer incidence and
mortality in the American Indian/Alaska Native (AI/AN) population; a goal that aligns with the mission and
vision of the National Cancer Institute.
AI/AN women are 1.5 times more likely to be diagnosed with cervical cancer and 2X as likely to die of the
disease compared to Non-Hispanic White women. Multiple risk factors contribute to the development of
cervical cancer including not accessing pap smear screening, smoking, socioeconomic status, and acquisition
of high-risk subtypes of the human papillomavirus (hrHPV). This proposal seeks to look deeper in to these
persistent health disparities by critically evaluating the utilization and applicability of cervical cancer prevention
tools such as HPV vaccination, pap smear screening, and distribution of high-risk HPV (hrHPV) types in the
AI/AN population. HPV vaccination is a primary prevention tool to prevent cervical cancer and its precursor
lesions with U.S. recommendations to vaccination youth ages 11-12. There are 14 types of high-risk HPV
(hrHPV) associated with cancer and types 16 and 18 contribute to ~70% of cancer cases. One of the proposed
study goals is to fully evaluate the HPV vaccination rates and trends and pap smear rates among Oregon
AI/AN. This data will to identify communities with high and low vaccination rates and focus groups of
healthcare providers and community members will occur to identify barriers and facilitators of HPV vaccination.
There are few studies evaluating the prevalence of hrHPV subtypes in AI/AN women and data suggest that
the distribution of the 14 types differ from the general U.S. population, which can lead to real clinical
consequences. First, vaccination may provide inadequate coverage for prevalent subtypes. Second,
colposcopy, an office-based procedure to more fully evaluate the cervix, is less sensitive at detecting dysplasia
due to non hrHPV 16 and 18 subtypes. A greater prevalence of other hrHPV subtypes in the AI/AN population
can lead to missed, early-stage disease. A cross-sectional study will be performed to determine the prevalence
and distribution of hrHPV among AI/AN women.
As part of the NCI mentored clinical scientist research career development award training award, Dr. Bruegl
will participate in a robust educational curriculum to successfully meet her goal of becoming an independent
clinician scientist. She has identified created a robust mentorship team and identified specific learning
objectives to help her meet this goal.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Persistent disparities of cervical cancer among American Indians/Alaska natives: Are we maximizing prevention tools?
美洲印第安人/阿拉斯加原住民之间宫颈癌的持续差异:我们是否最大限度地利用了预防工具?
- DOI:10.1016/j.ygyno.2022.11.007
- 发表时间:2023
- 期刊:
- 影响因子:4.7
- 作者:Bruegl,AS;Emerson,J;Tirumala,K
- 通讯作者:Tirumala,K
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Amanda S Bruegl其他文献
Persistent cervical cancer disparities among American Indian/Alaska Native women: a systematic scoping review exploring the state of the science in this population.
美洲印第安人/阿拉斯加原住民妇女中持续性宫颈癌的差异:一项探索该人群科学状况的系统范围审查。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Katherine Fitch;C. G. Nguyen;Cirila Estela Vasquez Guzman;Rebecca S Holmes;Amanda S Bruegl - 通讯作者:
Amanda S Bruegl
Acceptability of human papillomavirus self-collection and the role of telehealth: a prospective, randomized study stratified by menopausal status
人乳头瘤病毒自我采集的可接受性和远程医疗的作用:一项按绝经状态分层的前瞻性随机研究
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:4.8
- 作者:
Katherine Fitch;Jacqueline A. Bohn;Jenna Emerson;Emily R. Boniface;Amanda S Bruegl - 通讯作者:
Amanda S Bruegl
Amanda S Bruegl的其他文献
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{{ truncateString('Amanda S Bruegl', 18)}}的其他基金
Utilization of cervical cancer prevention tools and role of high-risk HPV type in the persistent cervical cancer disparities experienced by American Indian/Alaska Native women
宫颈癌预防工具的利用以及高危 HPV 类型在美洲印第安人/阿拉斯加原住民妇女经历的持续性宫颈癌差异中的作用
- 批准号:
10452479 - 财政年份:2021
- 资助金额:
$ 25.15万 - 项目类别:
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