Research Training for Physician-Scientists in Gastrointestinal Oncology

胃肠肿瘤学医师科学家研究培训

• 批准号: 10673988
• 负责人: DAFNA BAR-SAGI
• 金额: $ 24.56万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673988
• 关键词: Oncology; Physicians; Research Training; Scientist; gastrointestinal

Summary This is the first application for renewal of T32 CA193111 to continue funding the training of next generation of physician-scientists in gastrointestinal oncology. We believe that physician-scientists armed with rigorous research training are necessary to discover and translate new advances in GI oncology as well as to investigate critical issues facing delivery of cancer care to patients. Our trainees are drawn from NYU’s renowned clinical fellowship programs in Medical Oncology or Gastroenterology or top-notch residency programs in Radiation Oncology or Surgery. Trainees take a 2-3 year hiatus from clinical activities to engage in intensive full-time training in GI cancer research. Our program is composed of (i) a Basic/Translational Science track aimed at individuals who wish to direct their own basic science laboratory in GI oncology or individuals who want to lead translational research programs that comfortably interface between the pre-clinical laboratory and clinical investigation and (ii) a Population Sciences tract for trainees who seek careers in the diverse fields of population sciences including cancer epidemiology, comparative effectiveness, disparities, health services, or outcomes research. The program for our Basic/Translational Science track consists of two years of individualized mentored research in faculty laboratories, enhanced by a strong parallel didactic program in cancer biology. The Population Sciences track is centered on a rigorous Masters-level curriculum that teaches clinical trial design, epidemiology, comparative-effectiveness, and outcomes research methodologies along with a mentored research project based in population sciences. The two tracks are united through a weekly 2-hour core curriculum covering essential topics in GI cancer and critical lessons for cancer physicians embarking on independent investigative careers. We plan to continue to have a steady-state of 4 trainees at any given time. Our first group of graduates have been very successful in acquiring the research skills and credentials to eventually lead their own research groups. We are proud that our first graduates have obtained academic positions in oncology and submitted highly scored K grants. Our trainees are nurtured by a cadre of mentors with substantial accomplishments in cancer research and stellar training records. The aim of our training program is to continue to graduate physician- scientists armed with the intellectual capacity and tools to lead their own research programs and become leaders and role models in investigative GI oncology.

总结

项目成果

The Road to Precision Medicine in Chronic Obstructive Pulmonary Disease: Squeezing More Out of Chest Computed Tomography Scans.

慢性阻塞性肺疾病的精准医学之路：从胸部计算机断层扫描中挤出更多信息。

• DOI: 10.1513/annalsats.201712-945ed
• 发表时间: 2018
• 期刊: Annals of the American Thoracic Society
• 影响因子: 8.3
• 作者: Wu,BenjaminG;Segal,LeopoldoN
• 通讯作者: Segal,LeopoldoN

Mincle Signaling Promotes Con A Hepatitis.

• DOI: 10.4049/jimmunol.1600598
• 发表时间: 2016-10-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Greco SH;Torres-Hernandez A;Kalabin A;Whiteman C;Rokosh R;Ravirala S;Ochi A;Gutierrez J;Salyana MA;Mani VR;Nagaraj SV;Deutsch M;Seifert L;Daley D;Barilla R;Hundeyin M;Nikifrov Y;Tejada K;Gelb BE;Katz SC;Miller G
• 通讯作者: Miller G

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice.

• DOI: 10.1053/j.gastro.2016.02.070
• 发表时间: 2016-06
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Seifert L;Werba G;Tiwari S;Giao Ly NN;Nguy S;Alothman S;Alqunaibit D;Avanzi A;Daley D;Barilla R;Tippens D;Torres-Hernandez A;Hundeyin M;Mani VR;Hajdu C;Pellicciotta I;Oh P;Du K;Miller G
• 通讯作者: Miller G

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.

• DOI: 10.1038/cddis.2015.126
• 发表时间: 2015-05-07
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Deutsch M;Graffeo CS;Rokosh R;Pansari M;Ochi A;Levie EM;Van Heerden E;Tippens DM;Greco S;Barilla R;Tomkötter L;Zambirinis CP;Avanzi N;Gulati R;Pachter HL;Torres-Hernandez A;Eisenthal A;Daley D;Miller G
• 通讯作者: Miller G