Neurobiological impact of acute digital media abstinence among drug using college students

吸毒大学生急性数字媒体戒断的神经生物学影响

• 批准号: 10677380
• 负责人: Jessica Shannon Flannery
• 金额: $ 6.95万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677380
• 关键词: Abstinence; Ache; Acute; Affective; Agreement; Anhedonia; Anxiety; Automobile Driving; Behavior; Brain; Cellular Phone; Cognitive; Computers; Corpus striatum structure; Cues; Data Collection; Dependence; Development; Devices; Drug Withdrawal Symptoms; Drug usage; Education; Family; Funding; Habenular Nucleus; Health; Hydrocortisone; Incentives; Individual; Individual Differences; Intervention; Life; Life Experience; Link; Measurement; Measures; Neurobiology; Neurocognitive; Neurosciences; Outcome; Participant; Peripheral; Personality Traits; Pharmaceutical Preparations; Physiological; Physiology; Population; Postdoctoral Fellow; Prevalence; Psychological reinforcement; Psychosocial Factor; Public Health; Punishment; Recording of previous events; Recovery; Reporting; Research; Resolution; Rewards; Risk; Risk Factors; Salivary; Severities; Sleeplessness; Social Reinforcement; Stimulus; Stream; Structure; Substance Addiction; Substance Use Disorder; Substance abuse problem; Symptoms; System; Techniques; Technology; Training; Withdrawal; Withdrawal Symptom; Work; addiction; adolescent brain development; age group; aged; associated symptom; brain based; clinical practice; college; common symptom; comorbidity; craving; cue reactivity; digital; digital media; drug craving; drug use behavior; drug withdrawal; dysphoria; experience; inattention; interest; neural; neuroimaging; non-drug; prevent; response; reward processing; social; social norm; substance use; substance user; tv watching; university student; wireless fidelity; young adult

PROJECT SUMMARY Addictive drug use is highly prevalent among college-aged young adults and is linked to the development of substance use disorders and other negative health outcomes later in life. Thus, understanding factors driving use is a critical public health concern. While prior work has linked use to psycho-social factors, increased reliance on technological devices (e.g., mobile phones, computers, gaming consoles), has introduced new risk-factors that cannot be ignored. As digital media delivers a consistent stream of rewarding stimuli, heavy use has the potential to dysregulate neurobiological, reward processing systems implicated in drug use, and result in withdrawal symptoms when prevented. Digital withdrawal symptoms may intensify digital media craving, and craving for other rewards (e.g., drugs), in turn, leading to an increased risk for addictive digital media and drug use. Identifying symptoms of maladaptive technology use that may predispose young adults to escalating drug use is critical. The main objective of the proposed project is to characterize individual differences in neurocognitive digital withdrawal symptoms and drug craving, following a period of digital media abstinence, and assess associations with digital and drug use behaviors. Brain function, and withdrawal symptomology among drug using young adults will be examined before and after a period of digital media abstinence in which participants will surrender their mobile phone over-night and agree to not engage in any screen-time. Specifically, alterations in reinforcement processing brain function and responsivity to drug and technology cues, following acute digital abstinence, will be characterized (Aim 1). Drug craving and digital withdrawal symptoms (physiological, affective, cognitive) linked to acute digital media abstinence will be examined (Aim2). Finally, relations between individual differences in substance and digital media use history, observed digital withdrawal symptoms, and altered brain function will be examined (Aim3). The proposed aims will expand the PI’s existing experience in addiction neuroscience by allowing her to study comorbid risk for addictive digital and substance use and gain new training in, peripheral physiology measurement, high-resolution neuroimaging, and subcortical segmentation techniques.

项目摘要 成瘾性药物使用在大学年龄的年轻人中非常普遍，并与物质使用的发展有关 疾病和其他负面的健康结果。因此，了解驱动使用的因素是一个关键的公共卫生 关心虽然先前的工作已经将使用与心理社会因素联系起来，但对技术设备的依赖增加（例如，移动的 手机、电脑、游戏机），已经引入了新的风险因素，不容忽视。随着数字媒体提供了 持续的奖励刺激流，大量使用有可能使神经生物学，奖励处理失调 系统参与药物使用，并导致戒断症状时，预防。数字戒断症状可能 强化对数字媒体的渴望，以及对其他奖励的渴望（例如，药物），反过来，导致成瘾的风险增加 数字媒体和毒品使用。识别适应不良技术使用的症状，这些症状可能使年轻人容易 毒品使用的不断增加是至关重要的。拟议项目的主要目标是描述个体差异， 神经认知数字戒断症状和药物渴望，经过一段时间的数字媒体禁欲，并评估 与数字和药物使用行为的关联。青少年吸毒者脑功能与戒断行为的关系 成年人将在一段时间的数字媒体禁欲期之前和之后接受检查，在这段时间里，参与者将交出他们的 移动的电话过夜，并同意不从事任何屏幕时间。具体来说，强化处理的改变 急性数字戒断后，大脑功能和对药物和技术线索的反应将被表征（目的 1）。与急性数字媒体相关的药物渴望和数字戒断症状（生理，情感，认知） 将检查禁欲情况（目标2）。最后，个体差异与数字媒体使用之间的关系 将检查病史、观察到的手指戒断症状和脑功能改变（Aim3）。拟议目标 将扩大PI在成瘾神经科学方面的现有经验，允许她研究成瘾的共病风险。 数字和物质的使用，并获得新的培训，外周生理测量，高分辨率神经成像， 皮层下分割技术。