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A gut-brain interaction controlling reward learning

控制奖励学习的肠脑相互作用

基本信息

批准号：
10677021
负责人：
William Matthew Howe
金额：
$ 35.47万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-05 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677021
关键词：
Adaptive Behaviors Address Anatomy Appetitive Behavior Behavior Behavioral Big Data Brain Calories Carbohydrates Cells Code Collaborations Consumption Corpus striatum structure Data Data Analyses Disease Dissociation Dopamine Dorsal Drug abuse Eating Event Fatty acid glycerol esters Fiber Food Foundations Functional Magnetic Resonance Imaging Future Goals Human Immunohistochemistry Individual Infusion procedures Knowledge Label Lead Learning Link Macronutrients Nutrition Measures Mediating Mental Depression Midbrain structure Modeling Modernization Monitor Motivation Mus Natural Selections Neurobiology Neurons Neurosciences Nucleus Accumbens Nutrient Obesity Optics Oral cavity Pathway interactions Peripheral Phenotype Photometry Play Population Proteins Psychological reinforcement Research Research Support Rewards Role Self Stimulation Shapes Signal Transduction Statistical Models Stimulus Substantia nigra structure Support System System Techniques Technology Testing Time Training Ventral Tegmental Area Viral Vector Work computational neuroscience design dopamine system experimental study genetic manipulation gut-brain axis human subject neural novel recruit reinforced behavior response stem theories translational potential

项目摘要

Project Summary/Abstract The functions and computations supported by changes in the activity of meso-striatal dopamine systems are some of the most heavily researched, and hotly debated, topics in modern neuroscience. Predominant theories propose that they support reinforcement learning by broadcasting prediction-error signals, encode stimulus salience, or generally motivate reward seeking by representing internal states. Furthermore, it is widely accepted that these systems have been shaped by natural selection to reinforce adaptive behaviors. Eating, or the pursuit of nutrients, is fundamental for survival, and previous work has demonstrated that striatal DA circuits are critical components of the neurobiological systems that support this behavior. Importantly, emerging research supports a model whereby midbrain DA populations receive signals from the gut about food content that modify their activity and contribute to food learning and motivation. However, the timescale over which these gut-derived signals modulate DA release, and how they interact with DA signals previously identified as critical for food reward learning and motivation, is largely unknown. Here, we propose to address these gaps in our knowledge by using state of the art techniques to 1) Identify the ensembles of neurons in midbrain dopamine populations that are recruited by post-ingestive signals to control food reward. 2) Characterize the ability of post-ingestive signals to modify reward learning via effects on dopamine release in subregions of the striatum. 3)Test the causal role of post-ingestive signals for dopamine control of food reward. To accomplish these aims, we have assembled a team including behavioral and systems neuroscientists with expertise in modern technologies for recording and manipulating genetically defined cell populations, translational neuroscientists with expertise in the neurobiology of appetitive behaviors, statisticians specializing in big-data analysis, as well as leaders in the field of computational neuroscience. Completion of these studies will provide an opportunity to integrate peripheral modulation of midbrain dopamine systems into current models of dopamine control of reward learning and motivation, and provide a foundation for future studies of peripheral-central dopamine contributions to multiple adaptive functions and disease states.

项目总结/文摘