Modulation of gait dynamics post-stroke
中风后步态动力学的调节
基本信息
- 批准号:10677559
- 负责人:
- 金额:$ 7.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultBiofeedbackBiomechanicsCerebral PalsyCharacteristicsChildClassificationClinicalClinical TrialsComplementComplexComputational TechniqueDataData SetExhibitsExperimental DesignsFunctional disorderGaitGait speedGoalsHemiplegiaImpairmentIndividualIndividual DifferencesIndividualityJointsLeadLimb structureLiteratureMethodologyModelingMotionMovementMuscleNervous SystemNervous System TraumaNetwork-basedNeuromechanicsParesisPatternPrediction of Response to TherapyRehabilitation therapyResearchSeriesSpeedStrokeSubgroupTechniquesTestingTimeTrainingVisualWalkingWorkcareerdata-driven modeldesignflexibilitygait rehabilitationimprovedinnovationmodel designneuralnovelpatient populationpersonalized medicinepost strokerecurrent neural networkrehabilitation technologyresponseskillsstroke survivortreadmilltreatment responderstreatment responsewalking speed
项目摘要
PROJECT SUMMARY/ABSTRACT
My career goal is to improve the personalization of stroke gait rehabilitation and develop novel rehabilitation
technologies using neuromechanics-based data-driven modeling in conjunction with hypothesis-driven
experimental design. The proposed research aims to understand how neural constraints impact stroke survivors’
ability to coordinate execution-level joint dynamics to flexibly modulate whole-body center-of-mass (COM)
dynamics between slow inverted pendulum and fast spring-mass dynamics during walking; a task critical to
achieving stable, efficient, and rapid movement. My preliminary data in a single individual suggest that COM
dynamics are asymmetric post-stroke, but further characterization of joint coordination and COM dynamics is
needed to understand their relationship with interindividual and inter-limb differences in post-stroke walking
function and treatment responses. Two major methodological barriers to characterizing these relationships are
a lack of 1) metrics and techniques to encode complex, individual-specific gait dynamics post-stroke, and 2) long
time-series datasets containing diverse movement patterns needed to test neuromechanical hypotheses about
gait. To address these challenges, I will work with Sponsor Ting and Co-Sponsor Berman to extend data-
driven techniques developed in my doctoral research to identify COM dynamics and characterize their
relationships to joint dynamics; with Sponsor Ting and Co-Sponsor Kesar I will design and collect new datasets
from stroke survivors of diverse movement patterns using biofeedback during walking. Aim 1: Test whether
interindividual and inter-limb differences in COM dynamics post-stroke are associated with walking speed. I will
evaluate the similarity of baseline post-stroke COM dynamics to able-bodied (AB) adults and between paretic
and non-paretic limbs. Further, I will examine whether the paretic-limb transitions from inverted pendulum to
spring-mass dynamics at faster treadmill speeds, decreasing asymmetry in COM dynamics. Aim 2: Characterize
reductions in stroke survivors’ ability to modulate joint dynamics to achieve desired COM dynamics. Using visual
biofeedback to prescribe COM dynamics, I will test whether stroke survivors have reduced ability to emulate
COM dynamics compared to AB adults and determine if joint dynamics characterize COM dynamics less
accurately in stroke survivors than AB adults. Aim 3: Test whether sub-groups of individuals with similar COM
and joint dynamics predict biofeedback responses more accurately than discrete metrics. I will test whether,
across a range of biofeedback-prescribed COM dynamics, baseline COM and joint dynamics can classify
changes in joint dynamics with biofeedback more accurately than discrete clinical or biomechanical variables. I
will also have training in clinical trials by participating in Sponsor Kesar’s ongoing gait rehabilitation study. The
proposed research and training will complement my doctoral skillset, preparing me to lead independent research
combining experimental design and computational techniques to discover neuromechanical mechanisms
underlying gait dysfunction and develop novel gait rehabilitation for individuals with neurological injuries.
项目摘要/摘要
我的职业目标是提高中风步态康复的个性化,并开发新的康复
结合使用基于神经力学的数据驱动建模和假设驱动的技术
实验设计。这项拟议的研究旨在了解神经约束如何影响中风幸存者的
协调执行级关节动力学以灵活调整全身重心(COM)的能力
在慢速倒立摆和快速弹簧-质量动力学之间行走的动力学;这是一个关键的任务
实现稳定、高效、快速的运动。我个人的初步数据显示COM
动力学是不对称的卒中后,但关节协调和COM动力学的进一步特征是
需要了解它们与卒中后步行的个体间和肢体间差异的关系
功能和治疗反应。描述这些关系的两个主要方法障碍是
缺乏1)标准和技术来编码中风后复杂的、特定于个人的步态动态,以及2)长
包含不同运动模式的时间序列数据集需要测试以下神经力学假设
步态。为了应对这些挑战,我将与赞助商Ting和共同赞助商Berman合作,扩展数据-
在我的博士研究中开发的驱动技术,用于识别COM动态并描述其
与联合动力学的关系;与赞助商Ting和共同赞助商Kesar I将设计和收集新的数据集
来自不同运动模式的中风幸存者,在步行过程中使用生物反馈。目标1:测试是否
中风后COM动力学的个体间和肢体间差异与行走速度有关。这就做
评估健康人(AB)和偏瘫患者卒中后基础COM动力学的相似性
和非瘫痪的四肢。此外,我将研究偏瘫肢体是否从倒立摆过渡到
跑步机速度更快时的弹簧-质量动力学,减少COM动力学中的不对称性。目标2:确定特征
中风幸存者调节关节动力学以实现所需COM动力学的能力降低。使用可视
生物反馈规定COM动力学,我将测试中风幸存者是否具有降低的模拟能力
COM动力学与AB成年人的比较,并确定关节动力学是否更少地表征COM动力学
中风幸存者比AB成人更准确。目标3:测试具有相似COM的个体的子组
关节动力学比离散度量更准确地预测生物反馈反应。我会测试一下是否,
在一系列生物反馈规定的COM动力学中,基线COM和关节动力学可以分类
使用生物反馈比离散的临床或生物力学变量更准确地改变关节动力学。我
还将通过参与赞助商凯撒正在进行的步态康复研究,接受临床试验方面的培训。这个
拟议的研究和培训将补充我的博士技能,为我领导独立研究做好准备
结合实验设计和计算技术来发现神经力学机制
潜在的步态功能障碍,并为神经损伤患者开发新的步态康复。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Motor and cognitive deficits limit the ability to flexibly modulate spatiotemporal gait features in older adults with mild cognitive impairment.
运动和认知缺陷限制了轻度认知障碍的老年人灵活调节时空步态特征的能力。
- DOI:10.3389/fnhum.2023.1040930
- 发表时间:2023
- 期刊:
- 影响因子:2.9
- 作者:
- 通讯作者:
A machine learning approach to quantify individual gait responses to ankle exoskeletons.
一种机器学习方法,用于量化个体对脚踝外骨骼的步态反应。
- DOI:10.1101/2023.01.20.524757
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Ebers,MeganR;Rosenberg,MichaelC;Kutz,JNathan;Steele,KatherineM
- 通讯作者:Steele,KatherineM
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael Charles Rosenberg其他文献
Michael Charles Rosenberg的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 7.41万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 7.41万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 7.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 7.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 7.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)