Neurobiology Core C

神经生物学核心 C

基本信息

  • 批准号:
    10676993
  • 负责人:
  • 金额:
    $ 26.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-14 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

Project summary The overarching goal of the Chicago Center on Musculoskeletal Pain (C-COMP) is to foster and support research and training aimed at understanding the mechanisms underlying pain associated with musculoskeletal (MSK) diseases, with the ultimate goal of better managing and preventing it. To support high- quality, innovative research that will accelerate our understanding of the mechanisms underlying MSK pain and, hence, facilitate identification of new therapeutic targets, we will capitalize on existing expertise and resources to create a Neurobiology Core C that will provide state-of-the-art physiological, transcriptomal, and neuroanatomical tools as well as scientific expertise for studying the mechanisms of MSK pain. The methods offered in this core have been chosen to synergize with the behavioral assessments offered in Core B. Technologies for studying the mechanisms through which the peripheral and central nervous systems coordinate to produce pain signaling have become much more sophisticated over the last decade, leading to many new insights into the neural mechanisms underlying chronic pain states. Our laboratories at Rush and Northwestern University - in large parts through NIAMS supported funding - have led the way in developing these tools for use in studying MSK pain in particular. The adoption of these sophisticated techniques in the broader MSK field is, however, hindered by a lack of availability to most laboratories. The resources and services selected for this core have been chosen to fill this need. Our own combined cumulative experience (>50 years) and established innovation and international leadership in bridging the neuroscience and MSK fields, and our expertise in these various technologies provides us with unique qualifications for advising researchers studying the neurobiology of MSK pain. Aim 1. Establish a centralized service for assessing physiological changes in the peripheral nervous system of preclinical models of MSK disease. The Core will provide consultation, scientific expertise, technical training, and technical services for the evaluation of sensory neuron physiology through the use of calcium imaging, including in vivo calcium imaging, electrophysiology, and chemo/opto-genetics. Aim 2. Establish a centralized resource for transcriptomal analysis of the peripheral nervous system. The Core will provide training and technical services for collecting and preparing dorsal root ganglia (DRG) neurons for RNA-seq (bulk and single cell). Aim 3. Provide a centralized resource for studying plasticity in neuroanatomy in preclinical MSK models. The core will provide technical assistance and training for performing anatomical studies of the peripheral nervous system - particularly joint innervation, including intra-articular innervation, immunohistochemistry of DRG, RNAscope in situ hybridization, tissue culture of DRG cells, and genetic tools for labeling particular types of cells (reporter mice, AAVs), and lightsheet imaging. Aim 4. We will present seminars and provide training and enrichment programs for enhancing the understanding of C-COMP investigators in how to experimentally explore mechanisms of pain in MSK and rheumatic diseases.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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RICHARD J MILLER其他文献

RICHARD J MILLER的其他文献

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{{ truncateString('RICHARD J MILLER', 18)}}的其他基金

Neurobiology Core C
神经生物学核心 C
  • 批准号:
    10488613
  • 财政年份:
    2021
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression And Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    10169854
  • 财政年份:
    2020
  • 资助金额:
    $ 26.95万
  • 项目类别:
Small molecule CXCR4 modulators as molecular probes for studying AML
小分子 CXCR4 调节剂作为研究 AML 的分子探针
  • 批准号:
    9099791
  • 财政年份:
    2015
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression and Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    8829147
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression and Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    9053984
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression And Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    9757504
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression And Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    8480989
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression and Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    8655517
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression And Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    10380166
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:
Osteoarthritis Progression And Sensory Pathway Alterations
骨关节炎进展和感觉通路改变
  • 批准号:
    10626714
  • 财政年份:
    2013
  • 资助金额:
    $ 26.95万
  • 项目类别:

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