Neurobiology Core C
神经生物学核心 C
基本信息
- 批准号:10676993
- 负责人:
- 金额:$ 26.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-14 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdoptionAfferent NeuronsAnatomyAnimalsAreaBehavior assessmentBrainBrain imagingCalciumCellsCentral Nervous SystemChicagoCollaborationsCommunitiesConsultationsCore FacilityData AnalysesDevelopmentElectrophysiology (science)EvaluationFosteringFunctional Magnetic Resonance ImagingFundingFutureGeneticGenetic TranscriptionGoalsHumanImageImmunohistochemistryIn Situ HybridizationInternationalJointsKneeLabelLaboratoriesLeadershipLearningLightMethodsMicroscopyModelingMonitorMusMusculoskeletalMusculoskeletal DiseasesMusculoskeletal PainNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNeeds AssessmentNeuroanatomyNeurobiologyNeuronsNeurosciencesPainPain ResearchPathway interactionsPeripheral Nervous SystemPhysiologicalPhysiologyPositron-Emission TomographyPre-Clinical ModelPublicationsQualifyingReporterResearchResearch PersonnelResearch SupportResourcesRheumatismRunningServicesSpinal GangliaSurveysTechnical ExpertiseTechniquesTechnologyTrainingTranslationsUniversitiesWorkcell typechronic painexperienceganglion cellin vivo calcium imaginginnovationinsightnerve supplyneuromechanismnew technologynew therapeutic targetoptogeneticspain signalpre-clinicalpreventprogramssingle-cell RNA sequencingsynergismtissue culturetooltranscriptome sequencingvalidation studiesweb portal
项目摘要
Project summary
The overarching goal of the Chicago Center on Musculoskeletal Pain (C-COMP) is to foster and support
research and training aimed at understanding the mechanisms underlying pain associated with
musculoskeletal (MSK) diseases, with the ultimate goal of better managing and preventing it. To support high-
quality, innovative research that will accelerate our understanding of the mechanisms underlying MSK pain
and, hence, facilitate identification of new therapeutic targets, we will capitalize on existing expertise and
resources to create a Neurobiology Core C that will provide state-of-the-art physiological, transcriptomal, and
neuroanatomical tools as well as scientific expertise for studying the mechanisms of MSK pain. The methods
offered in this core have been chosen to synergize with the behavioral assessments offered in Core B.
Technologies for studying the mechanisms through which the peripheral and central nervous systems
coordinate to produce pain signaling have become much more sophisticated over the last decade, leading to
many new insights into the neural mechanisms underlying chronic pain states. Our laboratories at Rush and
Northwestern University - in large parts through NIAMS supported funding - have led the way in developing
these tools for use in studying MSK pain in particular. The adoption of these sophisticated techniques in the
broader MSK field is, however, hindered by a lack of availability to most laboratories. The resources and
services selected for this core have been chosen to fill this need. Our own combined cumulative experience
(>50 years) and established innovation and international leadership in bridging the neuroscience and MSK
fields, and our expertise in these various technologies provides us with unique qualifications for advising
researchers studying the neurobiology of MSK pain. Aim 1. Establish a centralized service for assessing
physiological changes in the peripheral nervous system of preclinical models of MSK disease. The
Core will provide consultation, scientific expertise, technical training, and technical services for the evaluation
of sensory neuron physiology through the use of calcium imaging, including in vivo calcium imaging,
electrophysiology, and chemo/opto-genetics. Aim 2. Establish a centralized resource for transcriptomal
analysis of the peripheral nervous system. The Core will provide training and technical services for
collecting and preparing dorsal root ganglia (DRG) neurons for RNA-seq (bulk and single cell). Aim 3. Provide
a centralized resource for studying plasticity in neuroanatomy in preclinical MSK models. The core will
provide technical assistance and training for performing anatomical studies of the peripheral nervous system -
particularly joint innervation, including intra-articular innervation, immunohistochemistry of DRG, RNAscope in
situ hybridization, tissue culture of DRG cells, and genetic tools for labeling particular types of cells (reporter
mice, AAVs), and lightsheet imaging. Aim 4. We will present seminars and provide training and
enrichment programs for enhancing the understanding of C-COMP investigators in how to experimentally
explore mechanisms of pain in MSK and rheumatic diseases.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RICHARD J MILLER其他文献
RICHARD J MILLER的其他文献
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{{ truncateString('RICHARD J MILLER', 18)}}的其他基金
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8829147 - 财政年份:2013
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9053984 - 财政年份:2013
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9757504 - 财政年份:2013
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8480989 - 财政年份:2013
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- 资助金额:
$ 26.95万 - 项目类别:
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- 资助金额:
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