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The Hemostasis, Thrombosis, and Inflammation Models Core

止血、血栓形成和炎症模型核心

基本信息

批准号：
10676889
负责人：
Wolfgang Bergmeier
金额：
$ 34.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-05 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676889
关键词：
Adoptive Transfer Affect Animal Model Antibodies Area Biochemistry Biological Assay Biophysics Bleeding time procedure Blood Platelets Carotid Arteries Data Data Analyses Development Doctor of Philosophy Equipment Feedback Genotype Hemostatic function IACUC Imaging Techniques In Vitro Individual Inferior vena cava structure Inflammation Injury Laser injury Lung Maintenance Megakaryocytes Mesentery Methodology Modeling Monomeric GTP-Binding Proteins Mouse Strains Mus Names North Carolina Procedures Production Protocols documentation Quarantine Reaction Reproducibility Research Research Personnel Resources Saphenous Vein Seminal Services Skin Stenosis Study models Tail Technical Expertise Thrombosis Universities Venous arteriole cost ferric chloride in vivo intravital microscopy laboratory experiment mid-career faculty mouse model neutrophil programs

项目摘要

Abstract The Hemostasis, Thrombosis, and Inflammation Models Core (Core A) will provide the resources, equipment and technical expertise to conduct the in vivo assays that are a critical component of all projects included in this program. The main services provided by the core are: 1. Organize shipment of mice from UC San Diego to UNC Chapel Hill and to establish colonies for select strains at UNC Chapel Hill 2. Subject mice to various models of hemostasis, thrombosis, and inflammation 3. Analyze data and provide project investigators with results and feedback on how to move forward with projects/ mouse model studies. Including an animal models core will increase reproducibility in results obtained for the various projects in this PPG, and drastically reduce costs for labor and set-up/ maintenance of major equipment. Core A will be directed by Dr. Wolfgang Bergmeier, an Associate Professor of Biochemistry and Biophysics at the University of North Carolina who has many years of expertise in the use of animal models (Hemostasis, Thrombosis, and Inflammation) and state-of-the-art intravital microscopy (IVM) imaging techniques. In his own research, he has made seminal contributions to our understanding of how the small GTPase Rap1 and its regulators affect platelet and neutrophil functions – a major focus area of this program.

摘要止血、血栓形成和炎症模型核心（核心A）将提供资源、设备和技术专长，以进行体内试验，这是所有项目的关键组成部分，包括在这个程序. 该中心提供的主要服务有： 1.组织将小鼠从加州大学圣地亚哥分校运送到加州查佩尔山，并建立选定菌株的菌落在北查佩尔山 2.使小鼠经受各种止血、血栓形成和炎症模型 3.分析数据，并向项目调查人员提供结果和反馈，以了解如何推进项目/小鼠模型研究包括一个动物模型核心将增加在这个项目中的各种项目所获得的结果的可重复性。 PPG，并大幅降低劳动力和主要设备的设置/维护成本。核心A将直接北卡罗来纳大学生物化学和生物物理学副教授Wolfgang Bergmeier博士卡罗莱纳在动物模型（止血、血栓形成和炎症）和最先进的活体显微镜（IVM）成像技术。在他自己的研究中，对我们理解小GTFP 1及其调节因子如何影响血小板做出了开创性的贡献和中性粒细胞功能-这一计划的主要重点领域。