The Hemostasis, Thrombosis, and Inflammation Models Core
止血、血栓形成和炎症模型核心
基本信息
- 批准号:10676889
- 负责人:
- 金额:$ 34.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-05 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Adoptive TransferAffectAnimal ModelAntibodiesAreaBiochemistryBiological AssayBiophysicsBleeding time procedureBlood PlateletsCarotid ArteriesDataData AnalysesDevelopmentDoctor of PhilosophyEquipmentFeedbackGenotypeHemostatic functionIACUCImaging TechniquesIn VitroIndividualInferior vena cava structureInflammationInjuryLaser injuryLungMaintenanceMegakaryocytesMesenteryMethodologyModelingMonomeric GTP-Binding ProteinsMouse StrainsMusNamesNorth CarolinaProceduresProductionProtocols documentationQuarantineReactionReproducibilityResearchResearch PersonnelResourcesSaphenous VeinSeminalServicesSkinStenosisStudy modelsTailTechnical ExpertiseThrombosisUniversitiesVenousarteriolecostferric chloridein vivointravital microscopylaboratory experimentmid-career facultymouse modelneutrophilprograms
项目摘要
Abstract
The Hemostasis, Thrombosis, and Inflammation Models Core (Core A) will provide the resources, equipment
and technical expertise to conduct the in vivo assays that are a critical component of all projects included in this
program.
The main services provided by the core are:
1. Organize shipment of mice from UC San Diego to UNC Chapel Hill and to establish colonies for select strains
at UNC Chapel Hill
2. Subject mice to various models of hemostasis, thrombosis, and inflammation
3. Analyze data and provide project investigators with results and feedback on how to move forward with
projects/ mouse model studies.
Including an animal models core will increase reproducibility in results obtained for the various projects in this
PPG, and drastically reduce costs for labor and set-up/ maintenance of major equipment. Core A will be directed
by Dr. Wolfgang Bergmeier, an Associate Professor of Biochemistry and Biophysics at the University of North
Carolina who has many years of expertise in the use of animal models (Hemostasis, Thrombosis, and
Inflammation) and state-of-the-art intravital microscopy (IVM) imaging techniques. In his own research, he has
made seminal contributions to our understanding of how the small GTPase Rap1 and its regulators affect platelet
and neutrophil functions – a major focus area of this program.
摘要
止血、血栓形成和炎症模型核心(核心A)将提供资源、设备
和技术专长,以进行体内试验,这是所有项目的关键组成部分,包括在这个
程序.
该中心提供的主要服务有:
1.组织将小鼠从加州大学圣地亚哥分校运送到加州查佩尔山,并建立选定菌株的菌落
在北查佩尔山
2.使小鼠经受各种止血、血栓形成和炎症模型
3.分析数据,并向项目调查人员提供结果和反馈,以了解如何推进
项目/小鼠模型研究
包括一个动物模型核心将增加在这个项目中的各种项目所获得的结果的可重复性。
PPG,并大幅降低劳动力和主要设备的设置/维护成本。核心A将直接
北卡罗来纳大学生物化学和生物物理学副教授Wolfgang Bergmeier博士
卡罗莱纳在动物模型(止血、血栓形成和
炎症)和最先进的活体显微镜(IVM)成像技术。在他自己的研究中,
对我们理解小GTFP 1及其调节因子如何影响血小板做出了开创性的贡献
和中性粒细胞功能-这一计划的主要重点领域。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wolfgang Bergmeier其他文献
Wolfgang Bergmeier的其他文献
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{{ truncateString('Wolfgang Bergmeier', 18)}}的其他基金
The Hemostasis, Thrombosis, and Inflammation Models Core
止血、血栓形成和炎症模型核心
- 批准号:
10229367 - 财政年份:2020
- 资助金额:
$ 34.75万 - 项目类别:
Small GTPases in the biology of platelets and megakaryocytes
血小板和巨核细胞生物学中的小 GTP 酶
- 批准号:
9899304 - 财政年份:2019
- 资助金额:
$ 34.75万 - 项目类别:
Small GTPases in the biology of platelets and megakaryocytes
血小板和巨核细胞生物学中的小 GTP 酶
- 批准号:
10577770 - 财政年份:2019
- 资助金额:
$ 34.75万 - 项目类别:
Small GTPases in the biology of platelets and megakaryocytes
血小板和巨核细胞生物学中的小 GTP 酶
- 批准号:
10377385 - 财政年份:2019
- 资助金额:
$ 34.75万 - 项目类别:
2017 The Cell Biology of Megakaryocytes & Platelets Gordon Research Conference & Gordon Research Seminar
2017 巨核细胞的细胞生物学
- 批准号:
9248106 - 财政年份:2017
- 资助金额:
$ 34.75万 - 项目类别:
Rap1 signaling in platelet homeostasis and vascular hemostasis
Rap1 信号在血小板稳态和血管止血中的作用
- 批准号:
9330204 - 财政年份:2016
- 资助金额:
$ 34.75万 - 项目类别:
Spatial regulation of platelet activation by Podoplanin-Clec2 signaling
Podoplanin-Clec2 信号传导对血小板活化的空间调节
- 批准号:
8761615 - 财政年份:2014
- 资助金额:
$ 34.75万 - 项目类别:
Novel strategies to prevent FcgRIIA-dependent platelet activation and thrombosis
预防 FcgRIIA 依赖性血小板活化和血栓形成的新策略
- 批准号:
8501660 - 财政年份:2011
- 资助金额:
$ 34.75万 - 项目类别:
Novel strategies to prevent FcgRIIA-dependent platelet activation and thrombosis
预防 FcgRIIA 依赖性血小板活化和血栓形成的新策略
- 批准号:
8321894 - 财政年份:2011
- 资助金额:
$ 34.75万 - 项目类别:
Novel strategies to prevent FcgRIIA-dependent platelet activation and thrombosis
预防 FcgRIIA 依赖性血小板活化和血栓形成的新策略
- 批准号:
8185343 - 财政年份:2011
- 资助金额:
$ 34.75万 - 项目类别:
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