Psychophysiological Correlates of Cognitive Bias Modification in Intermittent Explosive Disorder

间歇性爆发性障碍认知偏差修正的心理生理相关性

• 批准号: 10677927
• 负责人: Nicole Katherine Ciesinski
• 金额: $ 3.58万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677927
• 关键词: Address; Adult; Affect; Aftercare; Aggressive behavior; Area; Attention; Autonomic nervous system; Behavioral; Benign; Biological; Biological Factors; Chronic; Clinical Trials; Cognitive; Complex; Control Groups; Cues; DSM-V; Data; Development; Diagnosis; Diagnostic; Disease; Dose; Emotional; Equation; Etiology; Facial Expression; Feedback; Foundations; Functional disorder; Health; Heart Rate; Human; Impairment; Individual; Intermittent Explosive Disorders; Intervention; Left; Legal; Link; Literature; Measures; Mental disorders; Mentors; Methodology; Modification; Occupational; Outcome; Participant; Perception; Personality Disorders; Physiological; Placebo Control; Placebos; Population; Prevalence; Procedures; Psychopathology; Psychophysiology; Public Health; Race; Randomized; Randomized, Controlled Trials; Recurrence; Relaxation; Research; Research Personnel; Response Latencies; Sampling; Sinus Arrhythmia; Social Behavior; Societies; Socioeconomic Status; Supervision; Symptoms; Training; Withdrawal; attentional bias; biopsychosocial; comorbidity; comparison group; computerized; design; disorder control; efficacy evaluation; experience; indexing; information processing; insight; intervention program; novel; physical conditioning; programs; psychologic; respiratory; response; sex; social; treatment response

PROJECT SUMMARY/ABSTRACT Intermittent Explosive Disorder (IED) is the only disorder in the DSM-5 for which the cardinal symptom is recurrent aggressive outbursts. IED is a common and multidetermined mental illness, which, if left untreated, has a chronic and debilitating course that often involves interpersonal, occupational, and legal consequences, as well as adverse physical health outcomes. IED also is associated with a number of cognitive biases related to socioemotional information processing. Over-attentiveness to threatening information (attention bias) and the tendency to attribute hostile intent to others (interpretation bias) are known correlates of aggression more broadly, and aggressive behavior in IED specifically. Additionally, hyperarousal of the autonomic nervous system (ANS) following provocation has been demonstrated in aggressive individuals; however, this phenomenon has not yet been investigated in IED, nor has it been linked with the biased cognitive processing seen in the disorder. Understanding the biological correlates of such cognitive biases is crucial to developing an integrated biopsychosocial framework for IED. Further, understanding the mechanisms of cognitive bias modification (CBM) could advance targeted interventions for IED that address both cognitive and physiological dysfunction. Leveraging an existing randomized controlled trial led by my primary sponsor, the present study proposes to examine the relationship between cognitive (attentional and interpretive) biases and physiological reactivity following provocation both before and after a CBM intervention among individuals diagnosed with IED. At pre- treatment, both IED (n = 48) and non-aggressive personality disorder controls (PD; n = 48) will complete computerized measures of attention and interpretation biases, along with an aggression-provocation task (TAP; Taylor Aggression Paradigm), during which psychophysiological data (i.e., heart rate, respiratory sinus arrhythmia and electrodermal activity) will be collected. Following the pre-treatment assessment, participants in the IED group will be randomized into either (1) a four-week (8-session) computerized cognitive bias modification intervention (CBM; n = 24) or (2) a dose equated computerized placebo control (placebo, n = 24). In the CBM condition, the tasks are aimed at modifying the aforementioned attention and interpretation biases using corrective feedback between trials, whereas in the placebo condition, corrective feedback will not favor “non- hostile” responses, presumably leaving any existing cognitive biases unaffected. Post-treatment procedures will be identical to those at pre-treatment, in which cognitive biases are again measured via computerized tasks, and psychophysiological data are collected during the TAP. Results of this study will provide further insight into the pathophysiology of reactive aggression, the efficacy of CBM interventions for IED, and the development of novel interventions for IED that address cognitive and psychophysiological dysfunction that characterize the disorder. A training plan was designed to develop the applicant's expertise in the conceptual and methodological areas relevant to the proposed study and professional development toward becoming an independent researcher.

项目摘要/摘要 间歇性爆炸性障碍（IED）是DSM-5中唯一的基本症状障碍 经常出现的侵略性爆发。 IED是一种常见且多性的精神疾病，如果不加以治疗， 有一个长期衰弱的课程，通常涉及人际关系，占领和法律后果， 以及不利的身体健康结果。 IED也与许多与认知偏见有关 进行社会情感信息处理。过度关注威胁信息（注意偏见）和 将敌对意图归因于他人的趋势（解释偏见）是侵略性的已知相关性 广泛，专门的侵略性行为。另外，自主神经系统的高度 （ANS）在激进的个体中已经证明了以下挑衅；但是，这种现象有 尚未在IED中进行调查，也没有与该疾病中的偏见认知过程有关。 了解这种认知偏见的生物学相关性对于开发综合 IED的生物心理社会框架。此外，了解认知偏置修饰的机制（CBM） 可以推进针对IED的目标干预措施，以解决认知和身体功能障碍。 利用我的主要赞助商领导的现有的随机对照试验，本研究提案 检查认知（注意力和解释性）偏见与身体反应性之间的关系 在诊断为IED的个体中，在CBM干预之前和之后挑衅。在pre- 治疗，IED（n = 48）和非攻击性人格障碍控制（PD; n = 48）都将完成 注意力和解释偏见的计算机测量，以及积极进取的任务（点击； 泰勒侵略范式），在此期间心理生理数据（即心率，呼吸窦 将收集心律不齐和耳皮活动）。遵循预处理评估，参与者 IED组将被随机分为（1）为期四周（8节）计算机化认知偏差的修改 干预（CBM; n = 24）或（2）等效的计算机安慰剂控制（安慰剂，n = 24）。在CBM中 条件，任务旨在使用使用 试验之间的纠正反馈，而在安慰剂条件下，正确的反馈不会有利于“非 - 敌对的”回应，大概会使任何现有的认知偏见不受影响。治疗后的程序将 与预处理的人相同，在预处理中，认知偏见再次通过计算机化任务进行测量， 在水龙头期间收集心理生理数据。这项研究的结果将为您提供进一步的了解 反应性侵略的病理生理学，CBM干预措施的效率以及新颖的发展 IED的干预措施解决了该疾病的特征的认知和心理生理功能障碍。 培训计划旨在发展申请人在概念和方法论领域的专业知识 与拟议的研究和专业发展有关，以成为一名独立研究人员。