Psychophysiological Correlates of Cognitive Bias Modification in Intermittent Explosive Disorder

间歇性爆发性障碍认知偏差修正的心理生理相关性

• 批准号: 10677927
• 负责人: Nicole Katherine Ciesinski
• 金额: $ 3.58万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677927
• 关键词: Address; Adult; Affect; Aftercare; Aggressive behavior; Area; Attention; Autonomic nervous system; Behavioral; Benign; Biological; Biological Factors; Chronic; Clinical Trials; Cognitive; Complex; Control Groups; Cues; DSM-V; Data; Development; Diagnosis; Diagnostic; Disease; Dose; Emotional; Equation; Etiology; Facial Expression; Feedback; Foundations; Functional disorder; Health; Heart Rate; Human; Impairment; Individual; Intermittent Explosive Disorders; Intervention; Left; Legal; Link; Literature; Measures; Mental disorders; Mentors; Methodology; Modification; Occupational; Outcome; Participant; Perception; Personality Disorders; Physiological; Placebo Control; Placebos; Population; Prevalence; Procedures; Psychopathology; Psychophysiology; Public Health; Race; Randomized; Randomized, Controlled Trials; Recurrence; Relaxation; Research; Research Personnel; Response Latencies; Sampling; Sinus Arrhythmia; Social Behavior; Societies; Socioeconomic Status; Supervision; Symptoms; Training; Withdrawal; attentional bias; biopsychosocial; comorbidity; comparison group; computerized; design; disorder control; efficacy evaluation; experience; indexing; information processing; insight; intervention program; novel; physical conditioning; programs; psychologic; respiratory; response; sex; social; treatment response

PROJECT SUMMARY/ABSTRACT Intermittent Explosive Disorder (IED) is the only disorder in the DSM-5 for which the cardinal symptom is recurrent aggressive outbursts. IED is a common and multidetermined mental illness, which, if left untreated, has a chronic and debilitating course that often involves interpersonal, occupational, and legal consequences, as well as adverse physical health outcomes. IED also is associated with a number of cognitive biases related to socioemotional information processing. Over-attentiveness to threatening information (attention bias) and the tendency to attribute hostile intent to others (interpretation bias) are known correlates of aggression more broadly, and aggressive behavior in IED specifically. Additionally, hyperarousal of the autonomic nervous system (ANS) following provocation has been demonstrated in aggressive individuals; however, this phenomenon has not yet been investigated in IED, nor has it been linked with the biased cognitive processing seen in the disorder. Understanding the biological correlates of such cognitive biases is crucial to developing an integrated biopsychosocial framework for IED. Further, understanding the mechanisms of cognitive bias modification (CBM) could advance targeted interventions for IED that address both cognitive and physiological dysfunction. Leveraging an existing randomized controlled trial led by my primary sponsor, the present study proposes to examine the relationship between cognitive (attentional and interpretive) biases and physiological reactivity following provocation both before and after a CBM intervention among individuals diagnosed with IED. At pre- treatment, both IED (n = 48) and non-aggressive personality disorder controls (PD; n = 48) will complete computerized measures of attention and interpretation biases, along with an aggression-provocation task (TAP; Taylor Aggression Paradigm), during which psychophysiological data (i.e., heart rate, respiratory sinus arrhythmia and electrodermal activity) will be collected. Following the pre-treatment assessment, participants in the IED group will be randomized into either (1) a four-week (8-session) computerized cognitive bias modification intervention (CBM; n = 24) or (2) a dose equated computerized placebo control (placebo, n = 24). In the CBM condition, the tasks are aimed at modifying the aforementioned attention and interpretation biases using corrective feedback between trials, whereas in the placebo condition, corrective feedback will not favor “non- hostile” responses, presumably leaving any existing cognitive biases unaffected. Post-treatment procedures will be identical to those at pre-treatment, in which cognitive biases are again measured via computerized tasks, and psychophysiological data are collected during the TAP. Results of this study will provide further insight into the pathophysiology of reactive aggression, the efficacy of CBM interventions for IED, and the development of novel interventions for IED that address cognitive and psychophysiological dysfunction that characterize the disorder. A training plan was designed to develop the applicant's expertise in the conceptual and methodological areas relevant to the proposed study and professional development toward becoming an independent researcher.

项目总结/摘要 间歇性爆炸性障碍（IED）是DSM-5中唯一一种主要症状为 反复发作的攻击性爆发简易爆炸装置是一种常见的多因素精神疾病，如果不加以治疗， 有一个慢性和衰弱的过程，往往涉及人际关系，职业，和法律的后果， 以及不利的身体健康结果。IED还与一些认知偏见有关， to socio-emotional社会信息processing处理.对威胁性信息的过度关注（注意力偏差） 倾向于将敌对意图归因于他人（解释偏见）是已知的侵略性的相关因素， 广泛地说，特别是在简易爆炸装置中的攻击性行为。另外，自主神经系统的过度兴奋 (ANS)在攻击性个体中表现出以下挑衅;然而，这种现象 尚未在IED中进行调查，也没有与在这种疾病中看到的有偏见的认知过程联系起来。 了解这种认知偏差的生物学相关性对于开发一种综合的 简易爆炸装置的生物心理社会框架认知偏差修正（cognitive bias modification，CBM） 可以推进针对IED的有针对性的干预措施，解决认知和生理功能障碍。 利用我的主要申办者领导的现有随机对照试验，本研究建议 检查认知（注意力和解释）偏差和生理反应之间的关系 在被诊断患有简易爆炸装置的个人中，在建立信任措施干预之前和之后，在预- 治疗，IED（n = 48）和非攻击性人格障碍对照（PD; n = 48）将完成 注意力和解释偏差的计算机化测量，沿着攻击激发任务（TAP; 泰勒攻击范式），在此期间，心理生理数据（即，心率，呼吸窦 心律失常和皮肤电活动）。在治疗前评估后，参与者 IED组将被随机分为（1）为期四周（8次）的计算机认知偏差修正 干预（CBM; n = 24）或（2）剂量等同的计算机化安慰剂对照（安慰剂，n = 24）。信任措施 条件下，任务的目的是修改上述注意和解释偏见，使用 试验之间的纠正反馈，而在安慰剂条件下，纠正反馈将不会有利于“非- 敌对的”反应，大概不会影响任何现有的认知偏见。治疗后程序将 与治疗前相同，其中认知偏差再次通过计算机任务测量，并且 在TAP期间收集心理生理数据。这项研究的结果将进一步深入了解 反应性攻击的病理生理学，CBM干预IED的有效性，以及新的 针对IED的干预措施，解决认知和心理生理功能障碍，这是该疾病的特征。 设计了一项培训计划，以发展申请人在概念和方法领域的专门知识 与拟议的研究和专业发展有关，以成为独立的研究人员。