Pathways for innovation in Blood Transfusión Systems in Kenya (PITS Kenya)

肯尼亚输血系统创新之路（PITS Kenya）

• 批准号: 10677875
• 负责人: PRATAP KUMAR
• 金额: $ 65.25万
• 依托单位: STRATHMORE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677875
• 关键词: 3-Dimensional; Acute; Address; Administrator; Affect; Africa South of the Sahara; Attitude; Blood; Blood Banks; Blood Donations; Blood Transfusion; Caring; Clinical; Clinical Pathways; Collection; Communities; Complex; Consensus; Country; County; Critical Care; Development; Discipline of obstetrics; Engineering; Ensure; Failure; Goals; Health; Healthcare Systems; Hemorrhage; Hospitals; Income; Industrialization; International; Intervention; Kenya; Literature; Location; Maternal Mortality; Pathway interactions; Patients; Phase; Policy Maker; Politics; Postpartum Hemorrhage; Process; Public Health; Research; Resource-limited setting; Rural; Safety; Series; Services; Sickle Cell Anemia; Structure; System; Techniques; Technology; Testing; Time; Transfusion; Universities; Work; crowdsourcing; design; evidence base; experience; innovation; low and middle-income countries; malarial anemia; meetings; mobile computing; multidisciplinary; programs; rural setting; social; social media; socioeconomics; supply chain; technology validation; therapy design; trauma care; urban setting

PROJECT SUMMARY/ABSTRACT There is a critical shortage of blood that affects many countries in Sub-Saharan Africa. Blood collection rates in these regions are ten-fold lower than rates in high-income countries. According to the Kenya National Blood Transfusion Service (KNBTS), the country's healthcare system requires nearly 500,000 units of blood per year. Last year, collections reached just 30% of this mark. Unfortunately, the blood transfusion processes span a continuum from blood donation to safe delivery that is complex, expensive, and prone to failure. The consequences are devastating; postpartum hemorrhage, malarial anemia, sickle cell disease, and all other forms of acute hemorrhage claim millions of lives each year. Thus, optimizing blood transfusion services in LMICs represents both a major health challenge and a social imperative. The overarching goal of this project is to identify, develop, and test effective strategies to enhance the availability and delivery of safe blood for transfusion in Kenya. A research consortium led by Strathmore University and the Center for Public Health and Development (CPHD) in Nairobi has partnered with the University of Pittsburgh with the objective of defining and characterizing the blood transfusion system in Kenya in order to provide evidence for the effective implementation of a diverse set of interventions aimed at enhancing and streamlining the safe delivery of blood in both urban and rural Kenya. Our research team has designed a multidimensional three-by- three-by-three approach that consists of three clinical pathways determining the urgency of blood transfusions; three distinct socioeconomic contexts within Kenya that best represent both urban and rural settings; and three basic components of effective blood transfusion systems (availability, processing, and safe delivery). Our specific aims are: 1. Evaluate ground-level deficits in the continuum of banked blood transfusion — specifically availability, processing, and delivery — across three distinct socioeconomic contexts in Kenya (Nakuru, Siaya/Kisumu, and Turkana counties), and within three specific clinical contexts (emergent, urgent, planned); 2. Evaluate ground-level and consensus solutions to optimize the continuum of banked blood transfusion; and 3. Identify disruptive technologies for the implementation of safe and reliable blood transfusion strategies, including innovative supply-chain solutions and crowd-sourcing through social media and mobile technologies. This work will elucidate barriers to safe blood access and quantify the impacts of unavailable blood in each clinical situation. During the UH3 phase of the project, we aim to implement innovative, contextually appropriate, stakeholder- backed interventions to address deficits across the blood continuum, ultimately optimizing blood donation, collection, testing, and timely availability so that blood is given to the right patient at the right time and location, ensuring the highest quality of blood transfusion services in low resource areas.

项目总结/摘要 严重的血液短缺影响着撒哈拉以南非洲的许多国家。血液 这些区域的收缴率比高收入国家低十倍。 据肯尼亚国家输血服务中心（KNBTS）称，该国的医疗保健 系统每年需要近50万单位的血液。去年，收藏量仅达到30%， 这个马克。不幸的是，输血过程跨越了血液的连续性， 捐赠到安全交付是复杂的，昂贵的，容易失败。后果 是毁灭性的;产后出血，疟疾性贫血，镰状细胞病，和所有其他 各种形式的急性出血每年夺去数百万人的生命。因此，优化输血 在中低收入国家提供卫生服务既是一项重大的卫生挑战，也是一项社会需要。的 该项目的总体目标是确定、开发和测试有效的战略，以提高 在肯尼亚提供和提供安全输血。一个研究联盟， 斯特拉斯莫尔大学和内罗毕的公共卫生与发展中心（CPHD） 与匹兹堡大学合作，目的是定义和描述 肯尼亚的输血系统，以便为有效实施提供证据 一套旨在加强和简化安全输血的干预措施 在肯尼亚的城市和农村。我们的研究团队设计了一个多维的三乘- 三乘三的方法，包括三个临床路径确定的紧迫性， 输血;肯尼亚境内三种不同的社会经济背景，最能代表这两种情况 有效输血系统的三个基本组成部分 （可用性、处理和安全交付）。我们的具体目标是：1.评估地面 库存输血连续性的缺陷-特别是可用性，处理， 在肯尼亚三个不同的社会经济背景下（纳库鲁、锡亚亚/基苏穆和 图尔卡纳县），并在三个特定的临床背景下（紧急，紧急，计划）; 2。 评估基层和共识解决方案，以优化库血的连续性 输血;和3.识别颠覆性技术，以实现安全可靠的 输血战略，包括创新的供应链解决方案和众包 通过社交媒体和移动的技术。这项工作将阐明安全血液的障碍 访问和量化不可用血液在每种临床情况下的影响。在UH 3 在项目的第一阶段，我们的目标是实施创新的，适合背景的，利益相关者- 支持的干预措施，以解决整个血液连续体的赤字，最终优化血液 献血、采集、检测和及时可用，以便在适当的时间将血液提供给正确的患者。 正确的时间和地点，确保最高质量的输血服务， 资源领域。

项目成果

Global Needs and Barriers for Medical Research Education: Initiatives to Solve the Physician-Scientist Shortage.

医学研究教育的全球需求和障碍：解决医师科学家短缺的举措。

• DOI: 10.5195/ijms.2023.2011
• 发表时间: 2023-03-31
• 期刊: International journal of medical students
• 作者: Schneider MR;Makram AM;Bassey E;Găman MA;Egan C;Puyana JC;Bonilla-Escobar FJ
• 通讯作者: Bonilla-Escobar FJ