Cellular and Synaptic Hypothalamic Reorganization After Exercise Training

运动训练后细胞和突触下丘脑的重组

• 批准号: 10677764
• 负责人: KEVIN W WILLIAMS
• 金额: $ 42.93万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10677764
• 关键词: Acute; Agonist; Body Composition; Brain; Cell Nucleus; Chronic; Clinical; Collaborations; Cues; Data; Diabetes Mellitus; Electrophysiology (science); Energy Metabolism; Exercise; Feeding behaviors; Fiber; GCG gene; GLP-I receptor; Genetic; Glutamates; Hand; Hepatic; Hypothalamic structure; In Vitro; Learning; Link; Liver; Mediating; Metabolic; Metabolism; Modeling; Monitor; Mus; Neurons; Peripheral; Photometry; Physical activity; Physiological Adaptation; Pro-Opiomelanocortin; Property; Regulation; Reporter; Research; Role; Signal Transduction; Synapses; Testing; Therapeutic; Work; design; energy balance; exercise training; genetic approach; glucagon-like peptide 1; glucose metabolism; glucose production; glucose tolerance; improved; in vivo; insulin sensitivity; intraperitoneal; metabolic phenotype; mimetics; mouse model; neural circuit; neurotransmission; optogenetics; patch clamp; predictive modeling; presynaptic; response; vesicular glutamate transporter 2

Physical activity provides multiple metabolic benefits, including improved insulin sensitivity and body composition. Within the brain, less is known about the effects of exercise to acutely alter synaptic/cellular properties and how these effects contribute to altered metabolism. In the current proposal, we have found that CNS derived GLP-1 neurons are activated in response to exercise. Moreover, GLP-1 and GLP-1 mimetics mimic the effects of exercise on arcuate melanocortin neurons. Collectively, these data support the hypothesis that an NTS GLP-1 to arcuate POMC circuit is activated in response to exercise. We will identify cellular mechanisms through which exercise activates GLP-1 and melanocortin neurons. We will also determine a role for these acute/chronic cellular mechanisms to regulate metabolism.

体育活动提供多种代谢益处，包括改善胰岛素敏感性和身体