Cellular and Synaptic Reorganization after Exercise Training

肥胖症和糖尿病的发病率继续上升。令人担忧的是，这一趋势不仅限于 美国；相反，肥胖症及其并存疾病，如II型糖尿病正在上升， 对世界各地的公共健康构成严重威胁。因此，确定有效的体重控制策略 血糖控制是当务之急。锻炼对新陈代谢有多种益处，包括改善 胰岛素敏感性和身体成分。在大脑内，黑素皮质素系统是 代谢状态的信号和控制能量平衡和葡萄糖代谢的神经通路。在 目前的提议，我们将确定运动改变突触和细胞的细胞机制 下丘脑黑素皮质素神经元的特性。我们还将确定这些急性/慢性细胞的作用 调节新陈代谢的机制。

The incidence of obesity and diabetes continues to rise. Alarmingly this is a trend that is not limited to the United States; rather obesity and its co-morbidities such as type II diabetes mellitus are on the rise and pose a serious threat to public health around the world. Thus, identifying effective strategies for body weight and blood glucose control is a priority. Exercise provides multiple metabolic benefits, including improved insulin sensitivity and body composition. Within the brain, the melanocortin system is an interface between signals of metabolic state and neural pathways governing energy balance and glucose metabolism. In the current proposal, we will identify cellular mechanisms through which exercise alters the synaptic and cellular properties of hypothalamic melanocortin neurons. We will also determine a role for these acute/chronic cellular mechanisms to regulate metabolism.