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Cellular and Synaptic Reorganization after Exercise Training

运动训练后的细胞和突触重组

基本信息

批准号：
10247767
负责人：
KEVIN W WILLIAMS
金额：
$ 40.5万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-20 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10247767
关键词：
Acute Blood Glucose Body Composition Body Weight Brain Characteristics Chronic Cues Data Diabetes Mellitus Electrophysiology (science)Energy Metabolism Exercise Feeding behaviors Glutamates Goals Hand Hepatic Hypothalamic structure Incidence Insulin Resistance Leptin Liver Mediating Metabolic Metabolism Modeling Mus N-Methyl-D-Aspartate Receptors Neural Pathways Neurons Non-Insulin-Dependent Diabetes Mellitus Obesity Peptides Peripheral Physiological Adaptation Pro-Opiomelanocortin Property Public Health Regulation Reporter Role SF1 Signal Transduction Synapses System Testing United States base blood glucose regulation comorbidity design energy balance exercise training feeding glucose metabolism glucose production improved in vivo insulin sensitivity leptin receptor metabolic phenotype mouse model neuropeptide Y neurotransmission predictive modeling response trend vesicular glutamate transporter 2

项目摘要

The incidence of obesity and diabetes continues to rise. Alarmingly this is a trend that is not limited to the United States; rather obesity and its co-morbidities such as type II diabetes mellitus are on the rise and pose a serious threat to public health around the world. Thus, identifying effective strategies for body weight and blood glucose control is a priority. Exercise provides multiple metabolic benefits, including improved insulin sensitivity and body composition. Within the brain, the melanocortin system is an interface between signals of metabolic state and neural pathways governing energy balance and glucose metabolism. In the current proposal, we will identify cellular mechanisms through which exercise alters the synaptic and cellular properties of hypothalamic melanocortin neurons. We will also determine a role for these acute/chronic cellular mechanisms to regulate metabolism.

肥胖症和糖尿病的发病率继续上升。令人担忧的是，这一趋势不仅限于肥胖及其并发症如II型糖尿病正在上升，对全世界的公共卫生构成严重威胁。因此，确定体重的有效策略血糖控制是首要任务运动提供多种代谢益处，包括改善胰岛素敏感性和身体组成。在大脑中，黑皮质素系统是代谢状态和控制能量平衡和葡萄糖代谢的神经通路的信号。在目前的建议，我们将确定细胞机制，通过运动改变突触和细胞下丘脑黑皮质素神经元的特性。我们还将确定这些急性/慢性细胞调节新陈代谢的机制。