The Substance Abuse Treatment to HIV care (SAT2HIV-II) Project

从药物滥用治疗到艾滋病毒护理 (SAT2HIV-II) 项目

• 批准号: 10680594
• 负责人: Bryan R Garner
• 金额: $ 56.57万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680594
• 关键词: Address; Affect; Alcohols; Caring; Client; Climate; Clinical Trials; Consultations; Effectiveness; Effectiveness of Interventions; Epidemic; Feedback; Funding; Goals; HIV; Intervention; Knowledge; Measures; Mediating; National Institute of Drug Abuse; Outcome; Performance; Persons; Pharmaceutical Preparations; Public Health; Randomized; Reporting; Research; Rewards; Risk; Risk Behaviors; Service setting; Services; Site; Substance Use Disorder; Technology Transfer; Testing; Training; United States; Viral; addiction; anxiety symptoms; brief intervention; community organizations; cost effective; depressive symptoms; effectiveness testing; effectiveness/implementation trial; experimental study; implementation intervention; implementation outcomes; implementation research; implementation strategy; implementation/effectiveness; improved; improved outcome; innovation; medication compliance; misuse of prescription only drugs; motivational enhancement therapy; practice setting; public health relevance; response; substance abuse treatment; substance misuse; substance use; success; theories; transmission process; treatment as usual

Despite its relevance to public health, the integration of substance use services into HIV service settings has been limited to date. Substance misuse interventions such as motivational interviewing (MI) have been effective in clinical trials but can be challenging to implement in practice settings, including HIV community-based organizations (HIV-CBOs) that are essential to HIV care. Since 2014, the proposed research team has been conducting some of the most innovative, large-scale implementation research on this topic as part of the Substance Abuse Treatment to HIV Care (SAT2HIV) project. Funded by the National Institute on Drug Abuse (NIDA), this 39-site, dual-randomized, type 2 effectiveness-implementation hybrid trial simultaneously tested (1) the effectiveness of an MI-based brief intervention (MIBI) for substance misuse as an adjunct to usual care and (2) the effectiveness of team-focused Implementation & Sustainment Facilitation (ISF) as an adjunct to the Addiction Technology Transfer Center’s (ATTC’s) staff-focused strategy (i.e., online training + in-person training + feedback + consultation). Results from the SAT2HIV project showed that the ATTC+ISF strategy significantly improved implementation effectiveness (i.e., consistency and quality of implementation) and intervention effectiveness (i.e., effectiveness of MIBI to reduce substance misuse). However, even in the ATTC+ISF condition, room for improvement in implementation remained. Additionally, neither study condition resulted in sufficient sustainment. Thus, there is a need for implementation research to identify strategies that can further improve outcomes beyond the ATTC+ISF strategy. According to implementation effectiveness theory, implementation climate (i.e., the extent to which implementation is expected, supported, and rewarded) is a key mechanism of change through which an implementation strategy impacts implementation effectiveness. Although the ISF strategy already seeks to maximize implementation effectiveness by improving implementation climate, the proposed research team’s prior implementation research suggests that pay-for-performance (P4P; i.e., monetary bonuses for achieving predefined targets) is a strategy that may significantly enhance the effectiveness of the ATTC+ISF strategy. Thus, our research team proposes the SAT2HIV-II project, a 30-site, cluster-randomized, type 3 effectiveness-implementation hybrid trial to test the effectiveness of P4P (i.e., compare the ATTC+ISF strategy and the ATTC+ISF+P4P strategy) to significantly improve implementation outcomes (primary aim) and client outcomes (secondary aim). The 2019 Ending the HIV Epidemic initiative seeks to end the HIV epidemic within 10 years. This goal is achievable but may not be possible without improving the extent to which substance use services are integrated into HIV service settings. Although the SAT2HIV-II project focuses on testing strategies to improve the integration of an MIBI for substance misuse, the knowledge gained could help HIV-CBOs improve the integration of other innovations. As such, the SAT2HIV-II project has potential to have a large and sustained impact on improving public health.

尽管药物使用服务与公共卫生相关，但将药物使用服务纳入艾滋病毒服务环境已经取得了进展

项目成果

Testing the incremental effectiveness of pay-for-performance to improve implementation of a motivational interviewing brief intervention for substance use disorders in HIV settings: Results of a cluster-randomized type 3 hybrid trial.

测试按绩效付费的增量有效性，以改善艾滋病毒环境中物质使用障碍的动机性访谈简短干预的实施：整群随机 3 型混合试验的结果。

• DOI: 10.21203/rs.3.rs-3685134/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Garner,BryanR;Tueller,Stephen;Bradshaw,Michael;Speck,Kathryn;Satre,Derek;Rash,Carla;Donohoe,Tom;Mungo,Jackie;Philbrick,Sarah;Ruwala,Richa;Roosa,Mathew;Zehner,Mark;Ford2nd,James
• 通讯作者: Ford2nd,James

Priority domains, aims, and testable hypotheses for implementation research: Protocol for a scoping review and evidence map.

• DOI: 10.1186/s13643-020-01535-y
• 发表时间: 2020-12-03
• 期刊: Systematic reviews
• 影响因子: 3.7
• 作者: Garner BR;Patel SV;Kirk MA
• 通讯作者: Kirk MA

Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance.

• DOI: 10.1038/clpt.2012.201
• 发表时间: 2013-01
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7

Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.

• DOI: 10.1182/blood-2006-10-053801
• 发表时间: 2008-03
• 期刊: Blood
• 影响因子: 20.3
• 作者: Hong-lin Xu;Jun Yan;Yiming Huang;P. Chilton;C. Ding;Carrie L. Schanie;Li Wang;S. Ildstad