Data Portal Core
数据门户核心
基本信息
- 批准号:10678960
- 负责人:
- 金额:$ 33.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-13 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:Adipose tissueAffectApplied ResearchBiological MarkersCaringClinical SciencesClinical TrialsCloud ComputingCommunicationCommunitiesComplexConsumptionDataData CollectionData ScienceData SetData SourcesData Storage and RetrievalDemocracyDevelopmentDevicesDimensionsDisparateDoctor of PhilosophyEFRACEchocardiographyEcosystemElectrocardiogramElectronic Health RecordEnsureFAIR principlesFailureFast Healthcare Interoperability ResourcesFundingGoalsHealthHeartHeart failureHeterogeneityHomeImageIndividualInformaticsInfrastructureInsurance CarriersInternetInvestigationKidneyLeadLeadershipLogical Observation Identifiers Names and CodesLungMRI ScansMedicineMobile Health ApplicationMultiomic DataMuscleNational Heart, Lung, and Blood InstituteOnline SystemsParticipantPatientsPhenotypePrivatizationQualifyingRegistriesResearchResearch PersonnelResearch PriorityResourcesStrategic visionSyndromeTest ResultTestingTherapeuticTrans-Omics for Precision MedicineTranslational ResearchTranslationsUnited States Agency for Healthcare Research and QualityUnited States Centers for Medicare and Medicaid ServicesUnited States National Institutes of HealthUniversitiesUpdateVisualizationadvanced analyticsanalytical toolaugmented intelligencebiobankcatalystclinical investigationcohortdata de-identificationdata integrationdata portaldata resourcedata visualizationdiverse dataeffective therapyfrailtyfrontierhealth dataimprovedinteroperabilitymHealthmedical schoolsmembermobile applicationmultiple chronic conditionsmultiple omicsnovelnovel strategiesonline repositorypatient engagementpreservationprogramsremote consentsensorskeletal tissuestemtoolweb appworking group
项目摘要
PROJECT SUMMARY
Given the complexity of the heart failure with preserved ejection fraction (HFpEF) syndrome, there is a major
unmet need to create a comprehensive, resource that can integrate a wide variety of disparate data sources for
consumption by the greater scientific community. A relatively “siloed” approach to scientific investigation in
HFpEF has not resulted in therapeutic advances thus far; therefore, we must pivot to new approaches, including
wider sharing of de-identified data to researchers worldwide to allow for a greater number of novel investigations
using the data. For these reasons, a major advance in the clinical investigation of HFpEF will be the development
of an effective HeartShare Data Portal that capitalizes on the NHLBI BioData Catalyst resource; aggregates,
organizes and curates HeartShare data; and rapidly makes de-identified data available for analysis by qualified
investigators around the world. The NHLBI BioData Catalyst resource is ideally suited for the tasks of the
HeartShare program because it promotes findability, accessibility, interoperability, and reusability (FAIR-ness),
data democratization, robust search/analysis tools, cloud-based computing, and integration with the Trans-
Omics for Precision Medicine (TOPMed) program. It will also support NHLBI’s Strategic Vision objective of
leveraging emerging opportunities in data science in order to open new frontiers in HFpEF investigation. We
propose the following specific aims to accomplish the goals of the HeartShare Data Portal core: (1) To create a
comprehensive web-based HeartShare data portal that uses the existing infrastructure of the NHLBI BioData
Catalyst and is accessible to the research community, provides data storage/access and analytic tools, and
supports online phenotype/omics visualization. (2) To integrate data across an ecosystem of diverse datasets
and data resources applicable to HeartShare, including cohort data, clinical trial data, multi-omics data, EHR
data (including integration via the Fast Healthcare Interoperability Resources (FHIR) standard with Center for
Medicare and Medicaid Services and private insurer data), research testing, biomarkers, and an online repository
of de-identified images (e.g., echocardiograms, MRI scans, ECG tracings). (3) To create a comprehensive
patient engagement resource (web- and mobile-based platforms) using the Eureka platform to allow for (1)
remote consenting and completion of forms, (2) a communication portal for participants (with the ability for
patients to view their own individual data and test results, and aggregate HeartShare summary data); and data
collection for home devices, sensors, and mobile health applications.
项目总结
考虑到心力衰竭伴射血分数保留(HFpEF)综合征的复杂性,有一个主要的
未满足的需求是创建可集成各种不同数据源的全面资源,以
更大的科学界的消费。相对“孤立”的科学调查方法
到目前为止,HFpEF尚未导致治疗进展;因此,我们必须转向新的方法,包括
与世界各地的研究人员更广泛地共享未确认身份的数据,以便进行更多的新调查
使用这些数据。由于这些原因,HFpEF的临床研究将取得重大进展。
利用NHLBI BioData Catalyst资源的高效心脏共享数据门户;聚合、
组织和管理HeartShare数据;并快速将未识别的数据提供给合格的人员进行分析
世界各地的调查人员。NHLBI BioData Catalyst资源非常适合
HeartShare计划,因为它促进了可查找性、可访问性、互操作性和可重用性(公平),
数据民主化、强大的搜索/分析工具、基于云计算以及与Trans-
精准医学组学(TOPMed)计划。它还将支持NHLBI的战略愿景目标
利用数据科学领域新出现的机会,以开辟HFpEF调查的新领域。我们
提出以下具体目标以实现HeartShare数据门户核心的目标:(1)创建
全面的基于Web的HeartShare数据门户,使用NHLBI BioData的现有基础设施
Catalyst,可供研究社区访问,提供数据存储/访问和分析工具,以及
支持在线表型/组学可视化。(2)跨不同数据集的生态系统集成数据
和适用于HeartShare的数据资源,包括队列数据、临床试验数据、多组学数据、EHR
数据(包括通过快速医疗保健互操作性资源(FHIR)标准与Center for
Medicare和Medicaid服务和私营保险公司数据)、研究测试、生物标记物和在线存储库
对未识别的图像(例如,超声心动图、核磁共振扫描、心电描记)进行分析。(三)打造全面发展的
使用Eureka平台的患者参与资源(基于网络和移动平台),以实现(1)
远程同意和填写表格,(2)参与者的交流门户(能够
患者查看他们自己的个人数据和测试结果,并汇总心跳共享汇总数据);以及数据
收集家用设备、传感器和移动健康应用程序。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sanjiv J Shah其他文献
Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline HbAsub1c/sub levels (STEP-HFpEF DM): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial
司美格鲁肽在射血分数保留的肥胖相关心力衰竭和 2 型糖尿病患者中(无论基线糖化血红蛋白水平如何)(STEP-HFpEF DM):一项随机、安慰剂对照试验中心力衰竭和代谢结局的预先指定分析
- DOI:
10.1016/s2213-8587(24)00304-8 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:41.800
- 作者:
Melanie J Davies;Peter van der Meer;Subodh Verma;Shachi Patel;Khaja M Chinnakondepalli;Barry A Borlaug;Javed Butler;Dalane W Kitzman;Sanjiv J Shah;Signe Harring;Afshin Salsali;Søren Rasmussen;Dirk von Lewinski;Walter Abhayaratna;Mark C Petrie;Mikhail N Kosiborod;STEP-HFpEF Trials Committees and Investigators - 通讯作者:
STEP-HFpEF Trials Committees and Investigators
210 - Once-weekly semaglutide in heart failure with preserved ejection fraction and obesity: main results from the STEP-HFpEF trial
- DOI:
10.1016/j.orcp.2024.09.084 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:
- 作者:
Andrew Sindone;Mikhail Kosiborod;Steen Z Abildstrøm;Barry A Borlaug;Javed Butler;Søren Rasmussen;Melanie J Davies;G. Kees Hovingh;Dalane W Kitzman;Marie L Lindegaard;Daniél Vega Møller;Sanjiv J Shah;Marianne Bach Treppendahl;Subodh Verma;Mark C Petrie - 通讯作者:
Mark C Petrie
211 - Once-weekly semaglutide in patients with heart failure with preserved ejection fraction, obesity and type 2 diabetes: main results from the STEP-HFpEF DM trial
- DOI:
10.1016/j.orcp.2024.09.085 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:
- 作者:
Andrew Sindone;Mikhail Kosiborod;Mark C Petrie;Barry A Borlaug;Javed Butler;Melanie J Davies;G. Kees Hovingh;Dalane W Kitzman;Daniél Vega Møller;Marianne Bach Treppendahl;Subodh Verma;Thomas J Jensen;Karoline Liisberg;Marie L Lindegaard;Sanjiv J Shah - 通讯作者:
Sanjiv J Shah
Finerenone and new-onset diabetes in heart failure: a prespecified analysis of the FINEARTS-HF trial
非奈利酮与心力衰竭中新发糖尿病:FINEARTS-HF 试验的预先指定分析
- DOI:
10.1016/s2213-8587(24)00309-7 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:41.800
- 作者:
Jawad H Butt;Pardeep S Jhund;Alasdair D Henderson;Brian L Claggett;Akshay S Desai;Prabhakar Viswanathan;Peter Kolkhof;Patrick Schloemer;Flaviana Amarante;Carolyn S P Lam;Michele Senni;Sanjiv J Shah;Adriaan A Voors;Faiez Zannad;Bertram Pitt;Muthiah Vaduganathan;Scott D Solomon;John J V McMurray;FINEARTS-HF Committees and Investigators - 通讯作者:
FINEARTS-HF Committees and Investigators
Sanjiv J Shah的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sanjiv J Shah', 18)}}的其他基金
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 33.77万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 33.77万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 33.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 33.77万 - 项目类别:
Studentship