Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis

sipIT 干预对增加尿石症患者尿量的疗效

基本信息

  • 批准号:
    10679033
  • 负责人:
  • 金额:
    $ 59.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary Kidney stones affect an estimated 8.8% of American adults and direct medical costs exceed $10 billion annually. Five-year recurrence rates for stones have been as high as 40% and a standard guideline for prevention is to increase fluid intake enough to produce > 2.5 L of urine daily. Meeting these guidelines reduces stone recurrence rates by 50-60% yet patients’ adherence to fluid intake guidelines is commonly below 50%. Usual care for preventing a recurrence involves education about increasing fluid intake and dietary changes; however, the low adherence rate indicates that many patients would benefit from additional support in adhering to fluid intake guidelines. The long-term goal of this research is to reduce the recurrence of painful and costly stones by improving patient adherence to fluid intake guidelines (secondary prevention). Digital technology offers the promise of increasing reach and supporting treatment adherence but, to date, that promise has not been fully realized in clinical trials of digital tools for supporting treatment adherence. In a series of six preliminary studies, we engaged patients in developing and testing a context-sensitive digital tool called sipIT, a just-in-time adaptive intervention to promote fluid intake and increase urine output. We learned that patients are open to using digital tools provided those tools are integrated with their lifestyle and sensitive to the changing contexts of their lives. The resulting intervention, sipIT, incorporates a novel semi-automated tracking system to trigger smartphone notifications with context-sensitive reminders to drink. The reminder system was informed by contemporary theories of habit formation to support behavior change in the eventual absence of the technology. In this application, we propose to answer question, “Does sipIT increase 24-hour urine output more than usual care over a 3-month period?” Urine output was selected as a proximal surrogate endpoint based on clinical guidelines for preventing recurrence of kidney stones. The specific aims of this project are (1) to evaluate the efficacy of sipIT vs usual care for increasing urine output in patients with a history of kidney stones, and (2) to identify biological and behavioral moderators of intervention effects on urine output (heterogeneity of treatment effects). We propose a two-arm randomized controlled trial to achieve these aims. Patients will receive either usual care + sipIT (intervention group) or usual care alone (control group). We will evaluate 24-hour urine output, urine supersaturations, and fluid intake habit strength at baseline and 1, 3, and 12 months after intervention. If successful, this research will lead to a cost-effective intervention that leverages consumer technology so it can be scaled for dissemination and implementation in clinical practice to reduce the burden and cost of stones. It advances NIDDK goals of preventing noncancerous urologic diseases and may be applied to support other dehydration-related health concerns (e.g., urinary tract infections, cognitive performance, heat stress, post-surgical hospital readmissions).
项目总结

项目成果

期刊论文数量(0)
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专利数量(0)

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DAVID E. CONROY其他文献

DAVID E. CONROY的其他文献

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{{ truncateString('DAVID E. CONROY', 18)}}的其他基金

Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults
精准短信对增加活动不足的年轻人身体活动的功效
  • 批准号:
    10508980
  • 财政年份:
    2022
  • 资助金额:
    $ 59.72万
  • 项目类别:
Society of Behavioral Medicine 2022 Annual Meeting & Scientific Sessions
行为医学学会2022年年会
  • 批准号:
    10661113
  • 财政年份:
    2022
  • 资助金额:
    $ 59.72万
  • 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
  • 批准号:
    10452545
  • 财政年份:
    2020
  • 资助金额:
    $ 59.72万
  • 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
  • 批准号:
    10264150
  • 财政年份:
    2020
  • 资助金额:
    $ 59.72万
  • 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
  • 批准号:
    10831605
  • 财政年份:
    2020
  • 资助金额:
    $ 59.72万
  • 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
  • 批准号:
    10119792
  • 财政年份:
    2020
  • 资助金额:
    $ 59.72万
  • 项目类别:
Phase 1 clinical trial to develop a personalized adaptive text message intervention using control systems engineering tools to increase physical activity in early adulthood
第一阶段临床试验,利用控制系统工程工具开发个性化自适应短信干预,以增加成年早期的体力活动
  • 批准号:
    9922375
  • 财政年份:
    2018
  • 资助金额:
    $ 59.72万
  • 项目类别:
Phase 1 clinical trial to develop a personalized adaptive text message intervention using control systems engineering tools to increase physical activity in early adulthood
第一阶段临床试验,利用控制系统工程工具开发个性化自适应短信干预,以增加成年早期的体力活动
  • 批准号:
    10152695
  • 财政年份:
    2018
  • 资助金额:
    $ 59.72万
  • 项目类别:
MOTIVATION AND LEARNING
动机和学习
  • 批准号:
    7203564
  • 财政年份:
    2005
  • 资助金额:
    $ 59.72万
  • 项目类别:
Coach Training to Promote Social Development
教练培训促进社会发展
  • 批准号:
    6610121
  • 财政年份:
    2003
  • 资助金额:
    $ 59.72万
  • 项目类别:

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  • 批准号:
    10592441
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利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
  • 批准号:
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利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
  • 批准号:
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利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
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