Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
基本信息
- 批准号:10679033
- 负责人:
- 金额:$ 59.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:2 arm randomized control trialAdherenceAdultAffectAgeAlgorithmsAmericanBehaviorBehavior TherapyBehavioralBehavioral SciencesBiologic CharacteristicBiologicalCellular PhoneClinicalClinical TrialsCompanionsComplementConsumptionControl GroupsCuesCustomDehydrationDetectionDietDiseaseDissemination and ImplementationEducationEmergency department visitFocus GroupsFrequenciesFundingGesturesGoalsGuidelinesHabitsHealthHealth behavior changeHeat Stress DisordersHeterogeneityHourHydration statusIntakeInterventionKidney CalculiLearningLife StyleLiquid substanceManualsMediatingMedical Care CostsMethodsMonitorNational Institute of Diabetes and Digestive and Kidney DiseasesNegative ReinforcementsNotificationOutputPainPatient MonitoringPatientsPhysical activityPreventionPrevention GuidelinesRandomizedRecording of previous eventsRecurrenceReminder SystemsResearchSaltsSecondary PreventionSeriesServicesShapesSurrogate EndpointSurveysSystemTechniquesTechnologyTestingTimeUrinary CalculiUrinary tract infectionUrineUrologic DiseasesWateracceptability and feasibilityadaptive interventionadherence rateapplication programming interfacebehavior changeclinical practicecognitive performancecompliance behaviorcostcost effective interventiondata exchangedietarydigital technologydigital tooldrinkingdrinking behaviorefficacy evaluationefficacy testingevidence basefinancial incentivefitbitgroup interventionhealthy lifestylehospital readmissionimaging studyimprovedinnovationinterestintervention effectmeetingsmobile applicationnovelpatient engagementpreventsecondary outcomesensorsexsmart watchsmartphone applicationsupport toolstheoriestooltreatment adherencetreatment as usualtreatment effecttreatment responseurolithiasiswearable device
项目摘要
Project Summary
Kidney stones affect an estimated 8.8% of American adults and direct medical costs exceed $10 billion
annually. Five-year recurrence rates for stones have been as high as 40% and a standard guideline for
prevention is to increase fluid intake enough to produce > 2.5 L of urine daily. Meeting these guidelines
reduces stone recurrence rates by 50-60% yet patients’ adherence to fluid intake guidelines is commonly
below 50%. Usual care for preventing a recurrence involves education about increasing fluid intake and dietary
changes; however, the low adherence rate indicates that many patients would benefit from additional support
in adhering to fluid intake guidelines. The long-term goal of this research is to reduce the recurrence of painful
and costly stones by improving patient adherence to fluid intake guidelines (secondary prevention). Digital
technology offers the promise of increasing reach and supporting treatment adherence but, to date, that
promise has not been fully realized in clinical trials of digital tools for supporting treatment adherence. In a
series of six preliminary studies, we engaged patients in developing and testing a context-sensitive digital tool
called sipIT, a just-in-time adaptive intervention to promote fluid intake and increase urine output. We learned
that patients are open to using digital tools provided those tools are integrated with their lifestyle and sensitive
to the changing contexts of their lives. The resulting intervention, sipIT, incorporates a novel semi-automated
tracking system to trigger smartphone notifications with context-sensitive reminders to drink. The reminder
system was informed by contemporary theories of habit formation to support behavior change in the eventual
absence of the technology. In this application, we propose to answer question, “Does sipIT increase 24-hour
urine output more than usual care over a 3-month period?” Urine output was selected as a proximal surrogate
endpoint based on clinical guidelines for preventing recurrence of kidney stones. The specific aims of this
project are (1) to evaluate the efficacy of sipIT vs usual care for increasing urine output in patients with a history
of kidney stones, and (2) to identify biological and behavioral moderators of intervention effects on urine output
(heterogeneity of treatment effects). We propose a two-arm randomized controlled trial to achieve these aims.
Patients will receive either usual care + sipIT (intervention group) or usual care alone (control group). We will
evaluate 24-hour urine output, urine supersaturations, and fluid intake habit strength at baseline and 1, 3, and
12 months after intervention. If successful, this research will lead to a cost-effective intervention that leverages
consumer technology so it can be scaled for dissemination and implementation in clinical practice to reduce
the burden and cost of stones. It advances NIDDK goals of preventing noncancerous urologic diseases and
may be applied to support other dehydration-related health concerns (e.g., urinary tract infections, cognitive
performance, heat stress, post-surgical hospital readmissions).
项目摘要
据估计,8.8%的美国成年人患有肾结石,直接医疗费用超过100亿美元
每年一次。结石的五年复发率高达40%,这是治疗结石的标准指南
预防措施是增加液体摄入量,使其足以每天产生2.5 L的尿液。符合这些指导原则
将结石复发率降低50%-60%,但患者通常遵守液体摄入指南
低于50%。预防复发的常规护理包括关于增加液体摄入量和饮食的教育
变化;然而,低依从率表明许多患者将从额外的支持中受益
在坚持液体摄入指南方面。这项研究的长期目标是减少疼痛的复发
通过提高患者对液体摄入指南的依从性(二级预防),减少昂贵的结石。数位
技术提供了增加覆盖面和支持治疗依从性的承诺,但到目前为止,
在支持治疗依从性的数字工具的临床试验中,承诺尚未完全实现。在一个
一系列的六项初步研究,我们让患者开发和测试一个上下文敏感的数字工具
称为siPIT,这是一种及时的适应性干预措施,旨在促进液体摄取和增加尿量。我们了解到
患者对使用数字工具持开放态度,前提是这些工具与他们的生活方式和敏感性相结合
以适应他们不断变化的生活环境。由此产生的干预,siPIT,结合了一种新型的半自动
跟踪系统可以触发智能手机通知,并根据上下文提示饮酒。提醒:
系统被当代的习惯形成理论所启发,以支持最终的行为改变
缺乏这项技术。在此应用程序中,我们建议回答以下问题:SIPIT是否增加24小时
在3个月的时间里排出的尿量比平时护理的多吗?尿量被选为近端代用品
终点根据防止肾结石复发的临床指南。这样做的具体目的是
项目是:(1)评估有病史的患者接受sipit治疗与常规护理相比增加尿量的效果。
以及(2)确定干预尿量的生物和行为调节因素
(治疗效果的异质性)。为了达到这些目的,我们提出了一个双臂随机对照试验。
患者将接受常规护理+siPIT(干预组)或仅接受常规护理(对照组)。我们会
评估24小时尿量、尿液过饱和度和液体摄入习惯强度在基线和1、3和
干预后12个月。如果成功,这项研究将导致一种具有成本效益的干预措施,
消费者技术,以便它可以扩展以在临床实践中传播和实施,以减少
石头的负担和成本。它促进了NIDDK预防非癌症泌尿系统疾病和
可用于支持其他与脱水相关的健康问题(例如,尿路感染、认知
表现、热应激、术后再入院)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DAVID E. CONROY其他文献
DAVID E. CONROY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DAVID E. CONROY', 18)}}的其他基金
Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults
精准短信对增加活动不足的年轻人身体活动的功效
- 批准号:
10508980 - 财政年份:2022
- 资助金额:
$ 59.72万 - 项目类别:
Society of Behavioral Medicine 2022 Annual Meeting & Scientific Sessions
行为医学学会2022年年会
- 批准号:
10661113 - 财政年份:2022
- 资助金额:
$ 59.72万 - 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
- 批准号:
10452545 - 财政年份:2020
- 资助金额:
$ 59.72万 - 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
- 批准号:
10264150 - 财政年份:2020
- 资助金额:
$ 59.72万 - 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
- 批准号:
10831605 - 财政年份:2020
- 资助金额:
$ 59.72万 - 项目类别:
Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis
sipIT 干预对增加尿石症患者尿量的疗效
- 批准号:
10119792 - 财政年份:2020
- 资助金额:
$ 59.72万 - 项目类别:
Phase 1 clinical trial to develop a personalized adaptive text message intervention using control systems engineering tools to increase physical activity in early adulthood
第一阶段临床试验,利用控制系统工程工具开发个性化自适应短信干预,以增加成年早期的体力活动
- 批准号:
9922375 - 财政年份:2018
- 资助金额:
$ 59.72万 - 项目类别:
Phase 1 clinical trial to develop a personalized adaptive text message intervention using control systems engineering tools to increase physical activity in early adulthood
第一阶段临床试验,利用控制系统工程工具开发个性化自适应短信干预,以增加成年早期的体力活动
- 批准号:
10152695 - 财政年份:2018
- 资助金额:
$ 59.72万 - 项目类别:
相似海外基金
Structural Racism, Pharmacy Closures and Disparities in Medication Adherence Among Older Adult Medicare Part-D Beneficiaries
结构性种族主义、药房关闭以及老年人医疗保险 D 部分受益人的药物依从性差异
- 批准号:
10568717 - 财政年份:2023
- 资助金额:
$ 59.72万 - 项目类别:
Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services
接受部落卫生服务的成年美洲印第安人的药物依从性和心脏代谢控制指标
- 批准号:
10419967 - 财政年份:2022
- 资助金额:
$ 59.72万 - 项目类别:
Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services
接受部落卫生服务的成年美洲印第安人的药物依从性和心脏代谢控制指标
- 批准号:
10592441 - 财政年份:2022
- 资助金额:
$ 59.72万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10369750 - 财政年份:2021
- 资助金额:
$ 59.72万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10633248 - 财政年份:2021
- 资助金额:
$ 59.72万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10487516 - 财政年份:2021
- 资助金额:
$ 59.72万 - 项目类别:
Mhealth for Pre-exposure Prophylaxis Adherence by Young Adult MSM
Mhealth 促进年轻 MSM 遵守暴露前预防
- 批准号:
10228564 - 财政年份:2018
- 资助金额:
$ 59.72万 - 项目类别:
Mhealth for Pre-exposure Prophylaxis Adherence by Young Adult MSM
Mhealth 促进年轻 MSM 遵守暴露前预防
- 批准号:
9347041 - 财政年份:2017
- 资助金额:
$ 59.72万 - 项目类别:
Mindfulness training with HIV-positive youth and adult family members to improve treatment adherence
对艾滋病毒呈阳性的青少年和成年家庭成员进行正念训练,以提高治疗依从性
- 批准号:
9480702 - 财政年份:2016
- 资助金额:
$ 59.72万 - 项目类别:
Mindfulness training with HIV-positive youth and adult family members to improve treatment adherence
对艾滋病毒呈阳性的青少年和成年家庭成员进行正念训练,以提高治疗依从性
- 批准号:
9906853 - 财政年份:2016
- 资助金额:
$ 59.72万 - 项目类别: