The Protein Aggregation Conference: Exploring Rugged Landscapes

蛋白质聚集会议：探索崎岖的地形

• 批准号: 10681615
• 负责人: JEAN S BAUM
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681615
• 关键词: Address; Affect; African ancestry; Aging; Alzheimer' s Disease; Amyloid; Amyloidosis; Amyotrophic Lateral Sclerosis; Award; Basic Science; Biological; Biological Phenomena; Biology; Biophysics; Calendar; Cardiovascular Diseases; Cellular biology; Characteristics; Clinical; Clinical Research; Collaborations; Deposition; Discipline; Disease; Disease Progression; Educational workshop; Environment; Equilibrium; Feedback; Female; Funding; Gender; Genetic Polymorphism; Goals; Health; Human; Huntington Disease; Individual; Kidney; Knowledge; Latinx; Lightning; Liquid substance; Liver; Malignant Neoplasms; Measures; Membrane; Minority; Molecular; Nerve Degeneration; Nervous System; Neurodegenerative Disorders; Normal Range; Organ; Organelles; Parkinson Disease; Participant; Pathogenesis; Pathologic; Persons; Phase; Polymers; Prion Diseases; Prize; Process; Proteins; Published Comment; Regulation; Research; Research Personnel; Role; Running; Scientific Advances and Accomplishments; Scientist; Series; Severity of illness; Signal Pathway; Structure; Systemic disease; Technology; Therapeutic; Thinking; Tissues; Travel; Underrepresented Minority; Voting; base; beta pleated sheet; career development; design; diversity and inclusion; effective therapy; equity, diversity, and inclusion; experience; hearing impairment; improved; innovation; meetings; molecular scale; nervous system disorder; posters; programs; protein aggregation; success; summer research; symposium; therapeutic development

Project Summary Protein aggregation is critical to both normal and pathological biological phenomena. Inappropriate protein aggregation underpins many neurological and systemic diseases, especially those associated with aging. Despite enormous progress in the advancement of knowledge for how protein aggregation relates to disease pathogenesis there remain few effective therapies for these diseases - especially relative to the successes in cardiovascular diseases and cancer. Recent discoveries have unearthed numerous examples of functional protein aggregation in membraneless organelles and signaling pathways. The structural bases of such phenomena include not only amyloids and other ordered polymers but also liquid-liquid phase separation. The mechanisms and regulation of these forms of aggregation are still being deciphered, but are already illuminating fruitful intersections with pathological aggregation. These new directions in the field place protein aggregation at an energetic and exciting moment of progress. This R13 proposal seeks support for a FASEB Summer Research Conference on “Protein Aggregation: Exploring Rugged Landscapes”. This will be the fourteenth conference of a series that began in 1995. Our 4-day program will bring the best researchers on the most cutting- edge topics of the discipline, while emphasizing diversity, equity, and inclusion. We will use the R13 funding to support these measures and further increase engagement by junior researchers.

项目摘要 蛋白质聚集对正常和病理生物现象都是至关重要的。不适当的蛋白质 聚集是许多神经和系统疾病的基础，尤其是那些与衰老相关的疾病。 尽管在蛋白质聚集如何与疾病相关的知识方面取得了巨大的进步 发病机制目前对这些疾病的有效治疗方法仍然很少--特别是与 心血管疾病和癌症。最近的发现已经发现了许多功能性的例子 蛋白质在无膜细胞器和信号通路中的聚集。这样的结构基础 这种现象不仅包括淀粉样蛋白和其他有序聚合物，还包括液-液相分离。这个 这些聚集形式的机制和调控仍在破译中，但已经很有启发性 具有病理性聚集的富有成效的交叉口。这些领域的新方向是蛋白质聚集 在一个充满活力和令人兴奋的进步时刻。这份R13提案寻求对FASE B夏季的支持 “蛋白质聚集：探索崎岖地貌”研究会议。这将是14日 1995年开始的一系列会议的一部分。我们为期4天的计划将带来最好的研究人员在最尖端- 该学科的前沿话题，同时强调多样性、公平性和包容性。我们将使用R13资金来 支持这些措施，并进一步增加初级研究人员的参与。