The Protein Aggregation Conference: Exploring Rugged Landscapes

项目摘要 蛋白质聚集对正常和病理生物现象都是至关重要的。不适当的蛋白质 聚集是许多神经系统和全身性疾病的基础，特别是与衰老有关的疾病。 尽管在蛋白质聚集与疾病的关系方面取得了巨大进展 对于这些疾病的发病机制，仍然很少有有效的治疗方法-特别是相对于在 心血管疾病和癌症。最近的研究发现， 无膜细胞器中的蛋白质聚集和信号通路。这样的结构基础 这种现象不仅包括淀粉样蛋白和其它有序聚合物，还包括液-液相分离。的 这些聚集形式的机制和调节仍在被破译，但已经很有启发性 富有成效的交叉与病态的聚集。这些领域的新方向将蛋白质聚集 在一个充满活力和激动人心的进步时刻。此R13提案寻求对FASEB夏季的支持 研究会议上“蛋白质聚集：探索崎岖的景观”。这将是第十四次 这是1995年开始的一系列会议之一。我们为期4天的计划将带来最好的研究人员在最切割- 学科的边缘话题，同时强调多样性，公平性和包容性。我们将使用R13资金， 支持这些措施，进一步增加初级研究人员的参与。

Project Summary Protein aggregation is critical to both normal and pathological biological phenomena. Inappropriate protein aggregation underpins many neurological and systemic diseases, especially those associated with aging. Despite enormous progress in the advancement of knowledge for how protein aggregation relates to disease pathogenesis there remain few effective therapies for these diseases - especially relative to the successes in cardiovascular diseases and cancer. Recent discoveries have unearthed numerous examples of functional protein aggregation in membraneless organelles and signaling pathways. The structural bases of such phenomena include not only amyloids and other ordered polymers but also liquid-liquid phase separation. The mechanisms and regulation of these forms of aggregation are still being deciphered, but are already illuminating fruitful intersections with pathological aggregation. These new directions in the field place protein aggregation at an energetic and exciting moment of progress. This R13 proposal seeks support for a FASEB Summer Research Conference on “Protein Aggregation: Exploring Rugged Landscapes”. This will be the fourteenth conference of a series that began in 1995. Our 4-day program will bring the best researchers on the most cutting- edge topics of the discipline, while emphasizing diversity, equity, and inclusion. We will use the R13 funding to support these measures and further increase engagement by junior researchers.