BLRD Research Career Scientist Award Application

帕金森氏病(PD)的病因在很大程度上是未知的。临床前和流行病学研究提供了一种 老年、以前接触过杀虫剂与患帕金森氏症风险增加之间有很强的联系 疾病。这与退伍军人管理局特别相关，因为军事人员经常暴露在环境中 部署期间的毒素，包括杀虫剂。此外，退伍军人的年龄比美国还要大。 人口，因此面临更大的风险。最近的证据支持升高的生物醛在帕金森病中的作用。 这项拟议的工作不仅将有助于阐明帕金森氏症的发病机制，而且还将 确定降低生物醛的药物是否对帕金森氏症具有神经保护作用。这个 试验剂和潜在的替代品是FDA批准的药物，关于它们的信息很丰富 安全性和有效性。因此，如果这些临床前研究在帕金森病模型中显示出有效性，那么它们可能会更多 容易在临床上检验。

The etiology of Parkinson's disease (PD) is largely unknown. Preclinical and epidemiological studies provide a strong link between old age, prior exposure to pesticides and the increased risk of developing Parkinson's disease. This is of particular relevance to the VA because military personnel are often exposed to environmental toxins, including pesticides, during deployment. Moreover, the veteran population is older than the U.S. population and thus at increased risk. Recent evidence supports a role for elevated biogenic aldehydes in PD. The work proposed will not only help to elucidate the mechanisms underlying Parkinson's disease, but it will determine whether agents that lower biogenic aldehydes may be neuroprotective in Parkinson's disease. The test agent and potential alternatives are FDA-approved drugs for which there is abundant information on their safety and efficacy. Therefore, if these preclinical studies show efficacy in models of PD, then they may be more easily tested clinically.