San Antonio Claude D. Pepper Older Americans Independence Center

圣安东尼奥克劳德·D·佩珀美国老年人独立中心

• 批准号: 10670118
• 负责人: RANDY STRONG
• 金额: $ 124.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670118
• 关键词: 4 year old; Acceleration; Aging; Alzheimer' s disease pathology; American; Awareness; Behavior Therapy; Biology of Aging; Biometry; Callithrix; Capsicum; Cell Aging; Chronic Disease; Clinical; Clinical Pharmacology; Clinical Research; Clinical Trials; Clinical Trials Design; Cognitive; Collaborations; Communities; Development; Diamond; Disease; Education; Elderly; Epigenetic Process; Exercise; Foundations; Funding; GDF8 gene; Gerontology; Geroscience; Goals; Grant; Human; Immune; Inflammation; Informatics; Infrastructure; Institution; Intervention; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Longevity; Maintenance; Mediator; Metabolic dysfunction; Metformin; Methylene blue; Mitochondria; Modeling; Monkeys; Oxytocin; Patients; Pharmacology; Phase; Pilot Projects; Play; Policy Maker; Principal Investigator; Process; Qualifying; Research; Research Design; Research Personnel; Research Support; Resources; Scientist; Series; Services; Shock; Sirolimus; Site; Testing; Training; Translating; bench to bedside; clinical center; data management; disability; drug development; dysbiosis; education research; exhaustion; first-in-human; frailty; gut microbiome; healthspan; healthy aging; human disease; improved; innovation; knowledge base; lifestyle intervention; mTOR Inhibitor; meetings; microbiome; mild cognitive impairment; multidisciplinary; nonhuman primate; nutrition; operation; oral microbiome; pharmacologic; pre-clinical research; programs; recruit; sarcopenia; senescence; skills; square foot; stem cells; stress reduction; symposium; trial design; web site

A core tenet of the geroscience concept is that multiple human diseases arise from aging itself. Thus, the central theme of the San Antonio (SA) Claude D. Pepper Older Americans Independence Center (OAIC) is translational geroscience – moving research on the basic biology of aging from the laboratory bench to the clinic, with the overarching goal of promoting healthy aging and developing desperately needed treatments, mainly pharmacological, for aging-related diseases. This goal is achieved through the following Aims: 1) Expand the knowledge base in translational geroscience by catalyzing transformative research; 2) Create a cadre of multidisciplinary early-stage investigators with customized expertise in translational geroscience; 3) Serve as a resource and partner to investigators from other OAICs and institutions; and 4) Provide intellectual leadership, disseminate knowledge, and stimulate discussion on translational geroscience-related themes. The SA OAIC achieves these Aims through a Leadership and Administrative Core (LAC) that directs operations and sponsors several enrichment and dissemination activities; a Pilot and Exploratory Studies Core (PESC) that provides merit-based support for rigorously designed studies; a Research Education Component (REC) that expands a greatly needed cadre of uniquely qualified scientists cross-trained in aging biology and translational geroscience; a Pre-Clinical Research Core (RC1) which supports research in marmoset monkeys; a Clinical Research and Pharmacology Core (RC2) that delivers comprehensive trial support for recruitment/retention, assessments, pharmacology, and data management; and a Trial Design and Integrative Informatics Core (RC3) that provides comprehensive study design, biostatistics and informatics services. During the ~4 years since its funding, the SA OAIC supported 46 PIs, performing transformative translational geroscience-focused research in essentially all pillars/hallmarks of aging. For example, RC1 is conducting the only known lifespan and healthspan study on mTOR inhibitors in nonhuman primates. RC2 and RC3 carried out the first trial on rapamycin to examine immune and cognitive effects in healthy older adults and performed the first-in-man studies on senolytics. The OAIC supported 10 Scholars who are making transformative discoveries (e.g. first demonstration of cellular senescence as a key mediator of Alzheimer's pathology) and receiving highly competitive career development awards from the NIA/AFAR (Beeson, Irene Diamond) and the VA. The SA OAIC is built on a unique foundation provided by UTHSCSA's exceptional and tightly integrated resources: a Nathan Shock Center, a site of the Interventions Testing Program (ITP), a GRECC, a T32 Training Grant on Geroscience, and a robust Barshop Institute that unites aging research at UTHSCSA. We are the only OAIC with all of these synergistic components available. In addition, the SA OAIC receives unparalleled institutional commitment (~$600,000/year), including a new ~$100M 109,000 sq. ft. building – specific for the Barshop Institute – that will house the OAIC, Shock Center, and the ITP in a centrally located facility.

老年科学概念的核心原则是多种人类疾病都是由衰老本身引起的。因此， 圣安东尼奥 (SA) 克劳德·D·佩珀 (Claude D. Pepper) 美国老年人独立中心 (OAIC) 的中心主题 是转化性老年科学——将衰老的基础生物学研究从实验室推向现实 诊所的总体目标是促进健康老龄化和开发急需的治疗方法， 主要是药理作用，用于与衰老相关的疾病。这一目标是通过以下目标实现的： 1) 通过促进变革性研究，扩大转化老年科学的知识基础； 2）创建 一支由多学科早期研究人员组成的骨干队伍，具有转化老年科学方面的定制专业知识； 3） 充当其他 OAIC 和机构调查人员的资源和合作伙伴； 4）提供智力 领导力、传播知识并激发对转化老年科学相关主题的讨论。 SA OAIC 通过领导和行政核心 (LAC) 来实现这些目标，该核心负责指导 运营并赞助多项丰富和传播活动；试点和探索性研究核心 (PESC) 为严格设计的研究提供择优支持；研究教育的组成部分 （REC）扩大了急需的一支由独特合格的科学家组成的骨干队伍，他们在衰老生物学和 转化老年科学；支持狨猴研究的临床前研究核心（RC1）； 临床研究和药理学核心 (RC2)，为以下患者提供全面的试验支持 招募/保留、评估、药理学和数据管理；以及试验设计和综合 信息学核心 (RC3)，提供全面的研究设计、生物统计学和信息学服务。 自资助以来的约 4 年时间里，SA OAIC 支持了 46 名 PI，进行了变革性的转化 以老年科学为重点的研究，涉及衰老的几乎所有支柱/标志。例如，RC1 正在执行 唯一已知的针对非人类灵长类动物的 mTOR 抑制剂寿命和健康寿命的研究。 RC2 和 RC3 已完成 第一项雷帕霉素试验，旨在检查健康老年人的免疫和认知影响，并进行了 关于 senolytics 的首次人体研究。 OAIC 支持 10 名做出变革性发现的学者 （例如首次证明细胞衰老是阿尔茨海默病病理学的关键介质）并受到高度评价 NIA/AFAR（Beeson、Irene Diamond）和 VA 颁发的竞争性职业发展奖。 SA OAIC 建立在 UTHSCSA 卓越且紧密集成的独特基础之上 资源：内森休克中心、干预测试计划 (ITP) 站点、GRECC、T32 培训 Geroscience 的资助，以及一个强大的 Barshop 研究所，该研究所将 UTHSCSA 的老龄化研究结合起来。我们是唯一 OAIC 具有所有这些可用的协同组件。此外，SA OAIC 还获得无与伦比的 机构承诺（约 600,000 美元/年），包括约 1 亿美元的 109,000 平方英尺的新建筑 - 专门用于 Barshop Institute – 将在中心设施中容纳 OAIC、休克中心和 ITP。

项目成果

Binge eating among older women: prevalence rates and health correlates across three independent samples.

• DOI: 10.1186/s40337-021-00484-8
• 发表时间: 2021-10-19
• 期刊: Journal of eating disorders
• 影响因子: 4.1
• 作者: Wilfred SA;Becker CB;Kanzler KE;Musi N;Espinoza SE;Kilpela LS
• 通讯作者: Kilpela LS

Association of Insurance Type With Colorectal Surgery Outcomes and Costs at a Safety-Net Hospital: A Retrospective Observational Study.

• DOI: 10.1097/as9.0000000000000215
• 发表时间: 2022-12
• 期刊: Annals of surgery open : perspectives of surgical history, education, and clinical approaches

The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury.

• DOI: 10.1186/s13195-023-01301-x
• 发表时间: 2023-09-12
• 期刊: Alzheimer's research & therapy

Effect of Dietary Intake Through Whole Foods on Cognitive Function: Review of Randomized Controlled Trials.

通过全食摄入膳食对认知功能的影响：随机对照试验回顾。

• DOI: 10.1007/s13668-022-00412-5
• 发表时间: 2022
• 期刊: Current nutrition reports
• 影响因子: 4.9
• 作者: Jiwani,Rozmin;Robbins,Ronna;Neri,Alfonso;Renero,Jose;Lopez,Emme;Serra,MonicaC
• 通讯作者: Serra,MonicaC

Association of Insurance Type With Inpatient Surgery 30-Day Complications and Costs.

保险类型与住院手术 30 天并发症和费用的关联。

• DOI: 10.1016/j.jss.2022.09.006
• 发表时间: 2023
• 期刊: The Journal of surgical research
• 作者: Simon,RichardC;Kim,Jeongsoo;Schmidt,Susanne;Brimhall,BradleyB;Salazar,CamerinoI;Wang,Chen-Pin;Wang,Zhu;Sarwar,ZaheerU;Manuel,LauraS;Damien,Paul;Shireman,PaulaK
• 通讯作者: Shireman,PaulaK