Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic AD
通过经颅直流电刺激治疗失语性 AD,针对语言特异性和执行控制网络
基本信息
- 批准号:10701784
- 负责人:
- 金额:$ 80.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdjuvantAffectAftercareAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAmericanAnodesAnomiaAphasiaAreaAtrophicBehavior TherapyBiological MarkersBloodBrainCOVID-19 pandemicCaregiver BurdenCessation of lifeCharacteristicsClinicalClinical ResearchCognitiveCognitive deficitsCoinCombined Modality TherapyComplementControlled Clinical TrialsCoupledDevelopmentDiffusion Magnetic Resonance ImagingDiseaseDorsalDouble-Blind MethodEtiologyFunctional Magnetic Resonance ImagingGlutathioneImpairmentIndividualInferior frontal gyrusInterventionInvestigationLanguageLanguage DisordersLanguage TherapyLeftMagnetic Resonance SpectroscopyMeasuresMembrane PotentialsMemory impairmentModelingMonitorNamesNerve DegenerationNeurodegenerative DisordersNeuronal PlasticityNeuronsNeurosciencesNeurotransmittersOralOutcomeOxidative StressPathologyPatternPerformancePerfusionPharmacological TreatmentPhenotypePhysiologicalPrefrontal CortexPrimary Progressive AphasiaProbabilityRandomized Controlled Clinical TrialsResearchRestShort-Term MemorySleepSpeechStructure of supramarginal gyrusSymptomsSynaptic TransmissionTechniquesTestingTherapeuticTimeTrainingTranslatingUpdateVariantVerbal LearningWritingbehavior predictionbiomarker identificationbrain pathwaybrain volumeclinically significantcognitive functioncognitive performancecomparative efficacycostcost effective treatmentdisabilityeffective therapyexecutive functiongamma-Aminobutyric Acidimprovedlanguage impairmentlanguage outcomeneuralneuroimagingneurological rehabilitationneuroregulationnoveloutcome predictionperfusion imagingphonologypost interventionpredict responsivenesssexspellingstroke-induced aphasiatargeted treatmenttranscranial direct current stimulationtreatment effecttreatment researchverbalwhite matter
项目摘要
This project aims in developing treatments for an atypical Alzheimer's disease (AD) variant, usually affecting
the left hemisphere and comprising the logopenic variant primary progressive aphasia (lvPPA), thus, PPA-AD.
There are no pharmacological treatments available for PPA, and the only treatment shown to alleviate language
deficits is speech-language therapy. Treatment research in AD has emphasized targeting neuronal synaptic
transmission. We were amongst the first groups in the world to show the efficacy of a neuromodulation technique
that targets synaptic transmission (transcranial direct current stimulation, tDCS) in providing significant
symptomatic relief of language impairments in PPA. In the largest-to-date, double-blind, sham-controlled clinical
trial we demonstrated the efficacy of tDCS as an adjuvant for speech-language therapy for the treatment of
naming and spelling deficits in PPA. However, the efforts to slow language degeneration are hindered by the
fact that these individuals also suffer from additional cognitive deficits. This is especially true for individuals with
AD etiology (pathology and atrophy distribution). Early in the disease, individuals with PPA-AD present with
additional cognitive deficits such as verbal short-term memory impairment, even believed to be a primary
underlying cause of language deficits. However, treatment of these deficits has not been investigated in PPA-
AD using neuromodulation approaches. To address this gap, the proposed research aims to answer the following
question: How can we implement neurostimulation-based treatments to maximally generalize their
benefits to vital language/cognitive functions? We will do that by employing: (a) a behavioral therapy that
directly targets verbal short-term and working memory (vSTM/WM) deficits and that has been shown to
effectively generalize even to untrained language functions in post-stroke aphasia, and, (b) targeted neuro-
stimulation (high-definition tDCS) based on recent network-neuroscience and neuro-rehabilitation models. In
Aim 1, we will compare the efficacy of tDCS delivered over the left supramarginal gyrus (LSMG) vs. the left
dorsolateral prefrontal cortex (LDLPFC), both coupled with vSTM/WM behavioral treatment, specifically
examining the generalization of treatment effects to untrained vital language-specific and executive cognitive
functions in PPA-AD. In Aim 2, we will implement neuroimaging techniques to understand the mechanisms of
tDCS-induced changes in terms of: (a) network functional connectivity, (b) previous and novel metabolites such
as GABA and glutathione (related to oxidative stress in neurodegeneration), and (c) blood oxygenation, using
perfusion imaging. Finally, in Aim 3, we will evaluate novel predictors of responsiveness to tDCS such as
perfusion, sex and sleep, thus complementing our previously identified clinical, neural and behavioral predictors
(variant, brain volume and initial language/cognitive performance). A better understanding, based on recent
advances in network neuroscience, of how tDCS benefits may generalize to untrained language and executive
cognitive functions has the potential to revolutionize the development of effective treatments for PPA-AD.
该项目旨在开发非典型阿尔茨海默病(AD)变体的治疗方法,通常影响
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kyrana Tsapkini其他文献
Kyrana Tsapkini的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kyrana Tsapkini', 18)}}的其他基金
Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic AD
通过经颅直流电刺激治疗失语性 AD,针对语言特异性和执行控制网络
- 批准号:
10522359 - 财政年份:2022
- 资助金额:
$ 80.15万 - 项目类别:
Transcranial direct current stimulation in typical and atypical Alzheimer's disease
经颅直流电刺激治疗典型和非典型阿尔茨海默病
- 批准号:
10045358 - 财政年份:2020
- 资助金额:
$ 80.15万 - 项目类别:
Transcranial direct current stimulation in typical and atypical Alzheimer's disease
经颅直流电刺激治疗典型和非典型阿尔茨海默病
- 批准号:
10631954 - 财政年份:2020
- 资助金额:
$ 80.15万 - 项目类别:
Transcranial direct current stimulation in typical and atypical Alzheimer's disease
经颅直流电刺激治疗典型和非典型阿尔茨海默病
- 批准号:
10260455 - 财政年份:2020
- 资助金额:
$ 80.15万 - 项目类别:
Transcranial direct current stimulation in typical and atypical Alzheimer's disease
经颅直流电刺激治疗典型和非典型阿尔茨海默病
- 批准号:
10447136 - 财政年份:2020
- 资助金额:
$ 80.15万 - 项目类别:
Effects of tDCS on spoken and written production in Primary Progressive Aphasia
经颅直流电刺激 (tDCS) 对原发性进行性失语症口语和书面表达的影响
- 批准号:
9245668 - 财政年份:2015
- 资助金额:
$ 80.15万 - 项目类别:
Effects of tDCS on spoken and written production in Primary Progressive Aphasia
经颅直流电刺激 (tDCS) 对原发性进行性失语症口语和书面表达的影响
- 批准号:
8861556 - 财政年份:2015
- 资助金额:
$ 80.15万 - 项目类别:
Effects of tDCS on spoken and written production in Primary Progressive Aphasia
经颅直流电刺激 (tDCS) 对原发性进行性失语症口语和书面表达的影响
- 批准号:
9044746 - 财政年份:2015
- 资助金额:
$ 80.15万 - 项目类别:
相似海外基金
Metachronous synergistic effects of preoperative viral therapy and postoperative adjuvant immunotherapy via long-term antitumor immunity
术前病毒治疗和术后辅助免疫治疗通过长期抗肿瘤免疫产生异时协同效应
- 批准号:
23K08213 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving the therapeutic immunity of cancer vaccine with multi-adjuvant polymeric nanoparticles
多佐剂聚合物纳米粒子提高癌症疫苗的治疗免疫力
- 批准号:
2881726 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
Studentship
Countering sympathetic vasoconstriction during skeletal muscle exercise as an adjuvant therapy for DMD
骨骼肌运动期间对抗交感血管收缩作为 DMD 的辅助治疗
- 批准号:
10735090 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to predict benefit from extended duration of adjuvant endocrine therapy in the NSABP B-42 trial
NSABP B-42 试验中内分泌治疗敏感性 (SET ER/PR) 测定的评估,用于预测延长辅助内分泌治疗持续时间的益处
- 批准号:
10722146 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
AUGMENTING THE QUALITY AND DURATION OF THE IMMUNE RESPONSE WITH A NOVEL TLR2 AGONIST-ALUMINUM COMBINATION ADJUVANT
使用新型 TLR2 激动剂-铝组合佐剂增强免疫反应的质量和持续时间
- 批准号:
10933287 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
DEVELOPMENT OF SAS A SYNTHETIC AS01-LIKE ADJUVANT SYSTEM FOR INFLUENZA VACCINES
流感疫苗类 AS01 合成佐剂系统 SAS 的开发
- 批准号:
10935776 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE
流感病毒疫苗小分子双佐剂体系的研制
- 批准号:
10935796 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
A GLYCOLIPID ADJUVANT 7DW8-5 FOR MALARIA VACCINES
用于疟疾疫苗的糖脂佐剂 7DW8-5
- 批准号:
10935775 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
Adjuvant Photodynamic Therapy to Reduce Bacterial Bioburden in High-Energy Contaminated Open Fractures
辅助光动力疗法可减少高能污染开放性骨折中的细菌生物负载
- 批准号:
10735964 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别:
Adjuvant strategies for universal and multiseasonal influenza vaccine candidates in the context of pre-existing immunity
在已有免疫力的情况下通用和多季节流感候选疫苗的辅助策略
- 批准号:
10649041 - 财政年份:2023
- 资助金额:
$ 80.15万 - 项目类别: