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Effects of tDCS on spoken and written production in Primary Progressive Aphasia

经颅直流电刺激 (tDCS) 对原发性进行性失语症口语和书面表达的影响

基本信息

批准号：
9044746
负责人：
Kyrana Tsapkini
金额：
$ 75.23万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-02 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9044746
关键词：
Affect Aftercare Age-Years Alzheimer&apos s Disease Aphasia Area Behavior Therapy Behavioral Biological Neural Networks Brain Characteristics Clinical Clinical Research Clinical Trials Combined Modality Therapy Communication Coupled Crossover Design Data Dementia Development Diagnostic Diffusion Magnetic Resonance Imaging Disease Effectiveness Electrical Stimulation of the Brain Family Foundations Functional Magnetic Resonance Imaging Future Health Hour Image Individual Inferior frontal gyrus Intervention Language Language Disorders Language Therapy Left Life Light Link Long-Term Potentiation Measures Monitor Motor Motor Skills Names Nerve Degeneration Neurodegenerative Disorders Orthography Painless Participant Performance Primary Progressive Aphasia Production Protocols documentation Publishing Quality of life Reporting Research Resources Rest Stroke Support Groups Symptoms Synapses Syndrome Techniques Testing Therapeutic Time Training Work Writing alternative treatment clinically relevant cognitive ability cognitive function early onset effective therapy gray matter improved indexing insight intervention effect lexical neuroregulation novel phonology post intervention post stroke prognostic relating to nervous system skill acquisition skills spelling white matter

项目摘要

DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a relatively common clinical neurodegenerative syndrome that first and foremost affects language abilities. PPA usually has an early onset (50-60 years of age), detrimentally affecting work and family life. Spoken and written word production deficits are the earliest affected language skills with significant prognostic and diagnostic value for its course. There is no available treatment for affected individuals. Behavioral language therapy and naming and spelling interventions in particular have shown modest but encouraging gains, which, however, do not generalize to untrained items and do not sustain over time. Transcranial Direct Current Stimulation (tDCS) is a relatively new, safe, non-invasive, non-painful electrical stimulation of the brain; it has been shown to improve language and cognitive abilities in healthy controls and individuals with stroke and dementia when administered during language therapy. Repetitive and consecutive sessions of tDCS are thought to induce a type of long-term potentiation in the brain that affects synaptic connectivity. There is only one published study (by our group) supporting that tDCS coupled with spelling therapy has beneficial effects in people with PPA. In this project we propose to investigate the behavioral and neuromodulatory effects of tDCS during a combination of spoken and written word production therapy in PPA participants over time. In Specific Aim 1, we will test the hypothesis that anodal tDCS, when administered in combination with spoken and written word production therapy, will improve performance of individuals with PPA more than behavioral spoken and written word production therapy alone. We also hypothesize that improvements will be sustained over time and generalize to other language and cognitive functions subserved by the stimulated brain areas and will positively affect the quality of life of participants. In Speciic Aim 2, we test the hypothesis that changes in functional connectivity as measured by resting-state fMRI are greater after tDCS coupled with spoken and written word production intervention than after behavioral spoken and written word production intervention alone while controlling for gray matter volume and white matter tract loss as measured by volumetric and diffusion tensor imaging (DTI). Study results may help optimize future interventions in individuals with PPA or other neurodegenerative disease by providing novel treatment alternatives in a neurodegenerative syndrome with no proven effective treatment. A better understanding of the behavioral as well as functional connectivity changes due to tDCS will offer insights into ways of impeding neurodegeneration that may improve quality of life for individuals with PPA and other dementias.