Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV

测试针对艾滋病毒感染者的适应能力建设干预措施的功效和机制

• 批准号: 10702035
• 负责人: Pariya Fazeli Wheeler
• 金额: $ 4.11万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10702035
• 关键词: Address; Affect; African American; Aging; Behavior; Black race; Buffers; Complement; Data; Data Analyses; Data Collection; Data Set; Development; Development Plans; Elderly; Enrollment; Ensure; First Generation College Students; Future; Goals; Grant; HIV; Health; Intervention; Measures; Medical; Mentors; Mexican Americans; Outcome; Parents; Participant; Personality; Persons; Population; Positioning Attribute; Prevention strategy; Protocols documentation; Race; Reaction; Research; Research Training; Resources; Sampling; Severities; Stress; Stressful Event; Testing; Time; Training; Trauma; Treatment Efficacy; Work; adverse childhood events; career; career development; comorbidity; data dissemination; doctoral student; efficacy testing; experience; hands on research; health disparity; innovation; interest; promote resilience; psychologic; racial difference; racial disparity; resilience; sociodemographics; stress reactivity; stressor

PROJECT SUMMARY/ABSTRACT The purpose of this Diversity Supplement is to provide Mr. Jeremy Delgadillo, a Mexican American first- generation college graduate and first-year PhD student, research experience and training to promote his career development. This supplement will be nested in Dr. Pariya Wheeler’s R21 grant “Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV” (R21 AG076377- 01A1). The goal of the parent study is to test an adapted resilience intervention among 100 older PLHIV. This proposal is particularly innovative due to its use of the real-time ESM approach to assess intervention efficacy and mechanisms. Mr. Delgadillo will be positioned to leverage the rich baseline dataset from this parent R21 study to examine several important temporal associations between stress reactivity, resilience resources, and health outcomes among older PLWH. The baseline data collection will be complete within 1 year, allowing Mr. Delgadillo to engage in data analysis and dissemination in Year 2. Specifically, he will have baseline data on 100 PLHIV, which includes an extensive assessment to measure sociodemographics and stressful life events/trauma, health variables (e.g., comorbidities, HIV medical parameters), psychological functioning, and HIV treatment management. Furthermore, the baseline data will also include a 14-day ESM protocol that queries participants on stressful events, use of resilience resources, and affect. Importantly, given the diverse sample of ~50% African American/Black PLHIV that will be enrolled in this R21, Mr. Delgadillo will be well positioned to examine racial differences that may emerge in the findings, which aligns with his interests in racial and health disparities. Together, this rich dataset will allow Mr. Delgadillo to examine the following aims: AIM 1: To examine person-factors (e.g., race, SES, personality) as well as factors related to lifetime stress (e.g., lifetime adversity and adverse childhood events) and momentary stress (e.g., severity) as predictors of use of resilience resources (both global use and use of specific resources) following stressors. AIM 2: To examine whether specific resilience resources better predict stress reactivity, and whether resilience resources in turn predict better health outcomes (i.e., psychological functioning and HIV outcomes). Impact: These research findings will fill a significant gap in the field on understanding how PLWH react following stressors and how these behaviors impact health outcomes, which will inform the development of both prevention and intervention strategies. Importantly, these results will supplement and complement the results from the primary aims of the parent study that will assess intervention efficacy and mechanisms. The research training and career development plan proposed by Mr. Delgadillo and his mentoring team will ensure he is able to succeed in his future career, and will also prepare him to submit a successful F31 application at the end of the supplement.

项目摘要/摘要 本多样性补充的目的是为墨西哥裔美国人杰里米·德尔加迪洛先生提供- 一代大学毕业生和一年级博士生，研究经验和培训，以促进他的 职业发展。该补充将嵌套在Pariya惠勒博士的R21赠款“测试的有效性， 和艾滋病毒感染者老龄化适应性复原力建设干预机制”（R21 AG 076377- 01A1）。父母研究的目标是在100名老年艾滋病毒感染者中测试适应性弹性干预。这 该提案特别具有创新性，因为它使用了实时ESM方法来评估干预效果 和机制。Delgadillo先生将能够利用这家母公司丰富的基准数据集 R21研究，以检查压力反应性，恢复力 资源和老年艾滋病毒携带者的健康结果。基线数据收集将在1 这使Delgadillo先生能够在第二年从事数据分析和传播工作。具体来说，他将有 100名艾滋病毒感染者的基线数据，其中包括广泛的评估，以衡量社会人口统计学， 压力性生活事件/创伤，健康变量（例如，合并症、HIV医学参数）、心理 以及艾滋病毒治疗管理。此外，基线数据还将包括为期14天的ESM 询问参与者关于压力事件、弹性资源的使用和影响的协议。重要的是， 考虑到将在R21中登记的约50%的非洲裔美国人/黑人PLHIV的多样化样本， 德尔加迪洛将很好地研究种族差异，可能出现在调查结果， 符合他对种族和健康差异的兴趣总之，这个丰富的数据集将使德尔加迪洛先生 检查以下目标：目标1：检查人的因素（例如，种族、社会地位、个性）以及 与寿命应力相关的因素（例如，一生的逆境和不良的童年事件）和瞬间的压力 (e.g.,严重程度）作为复原力资源使用情况（全球使用情况和具体资源使用情况）的预测指标 压力源之后。目的2：检验特定的弹性资源是否能更好地预测压力反应， 以及弹性资源是否反过来预测更好的健康结果（即，心理功能和艾滋病毒 成果）。影响：这些研究结果将填补该领域在了解PLWH如何 压力源后的反应以及这些行为如何影响健康结果，这将为发展提供信息。 预防和干预策略。重要的是，这些结果将补充和补充 来自母研究的主要目的的结果，将评估干预效果和机制。的 Delgadillo先生及其指导小组提出的研究培训和职业发展计划将确保 他能够在未来的职业生涯中取得成功，并将为他成功提交F31申请做好准备， 补充的结尾。