Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV

项目摘要/摘要 这份多样性副刊的目的是为墨西哥裔美国人Jeremy Delgadillo先生提供第一- 一代大学毕业生和一年级博士生，研究经验和培训，以促进HIS 职业发展。这一补充将嵌套在Pariya Wheeler博士的R21拨款中 在艾滋病毒携带者中进行适应性复原力建设干预的机制“(R21 AG076377- 01A1)。家长研究的目标是在100名老年PLHIV患者中测试适应性复原力干预。这 该方案特别具有创新性，因为它使用了实时ESM方法来评估干预效果 和机械装置。Delgadillo先生将利用来自母公司的丰富基线数据集 R21研究考察应激反应性、恢复力之间的几个重要时间关联 资源，以及老年妇女保健中心的健康结果。基线数据收集将在%1内完成 年，允许Delgadillo先生在第二年从事数据分析和传播。具体地说，他将拥有 关于100名艾滋病毒感染者的基线数据，其中包括一项衡量社会人口统计和 应激性生活事件/创伤、健康变量(例如，合并症、艾滋病毒医学参数)、心理 运作，以及艾滋病毒治疗管理。此外，基准数据还将包括14天的ESM 询问参与者有关压力事件、弹性资源的使用和影响的协议。重要的是 考虑到约50%的非洲裔美国人/黑人PLHIV将参加R21的多样化样本，李先生说。 Delgadillo将很好地检查调查结果中可能出现的种族差异，这 与他对种族和健康差距的兴趣一致。总而言之，这个丰富的数据集将使Delgadillo先生 审查以下目标：目标1：审查人的因素(例如，种族、社会地位、个性)以及 与终生压力(如终生逆境和不良童年事件)和瞬间压力有关的因素 (例如，严重性)作为复原力资源使用的预测指标(包括全球使用和特定资源的使用) 追随压力源。目标2：检验特定的弹性资源是否能更好地预测应激反应， 以及韧性资源是否反过来预测更好的健康结果(即心理功能和艾滋病毒 结果)。影响：这些研究结果将填补该领域在了解PLWH如何 跟随应激源做出反应，以及这些行为如何影响健康结果，这将为发展提供信息 预防和干预策略。重要的是，这些结果将补充和补充 来自将评估干预效果和机制的母体研究的主要目标的结果。这个 Delgadillo先生和他的指导团队提出的研究、培训和职业发展计划将确保 他能够在未来的职业生涯中取得成功，并将为他在以下地址提交成功的F31申请做好准备 副刊的末尾。

PROJECT SUMMARY/ABSTRACT The purpose of this Diversity Supplement is to provide Mr. Jeremy Delgadillo, a Mexican American first- generation college graduate and first-year PhD student, research experience and training to promote his career development. This supplement will be nested in Dr. Pariya Wheeler’s R21 grant “Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV” (R21 AG076377- 01A1). The goal of the parent study is to test an adapted resilience intervention among 100 older PLHIV. This proposal is particularly innovative due to its use of the real-time ESM approach to assess intervention efficacy and mechanisms. Mr. Delgadillo will be positioned to leverage the rich baseline dataset from this parent R21 study to examine several important temporal associations between stress reactivity, resilience resources, and health outcomes among older PLWH. The baseline data collection will be complete within 1 year, allowing Mr. Delgadillo to engage in data analysis and dissemination in Year 2. Specifically, he will have baseline data on 100 PLHIV, which includes an extensive assessment to measure sociodemographics and stressful life events/trauma, health variables (e.g., comorbidities, HIV medical parameters), psychological functioning, and HIV treatment management. Furthermore, the baseline data will also include a 14-day ESM protocol that queries participants on stressful events, use of resilience resources, and affect. Importantly, given the diverse sample of ~50% African American/Black PLHIV that will be enrolled in this R21, Mr. Delgadillo will be well positioned to examine racial differences that may emerge in the findings, which aligns with his interests in racial and health disparities. Together, this rich dataset will allow Mr. Delgadillo to examine the following aims: AIM 1: To examine person-factors (e.g., race, SES, personality) as well as factors related to lifetime stress (e.g., lifetime adversity and adverse childhood events) and momentary stress (e.g., severity) as predictors of use of resilience resources (both global use and use of specific resources) following stressors. AIM 2: To examine whether specific resilience resources better predict stress reactivity, and whether resilience resources in turn predict better health outcomes (i.e., psychological functioning and HIV outcomes). Impact: These research findings will fill a significant gap in the field on understanding how PLWH react following stressors and how these behaviors impact health outcomes, which will inform the development of both prevention and intervention strategies. Importantly, these results will supplement and complement the results from the primary aims of the parent study that will assess intervention efficacy and mechanisms. The research training and career development plan proposed by Mr. Delgadillo and his mentoring team will ensure he is able to succeed in his future career, and will also prepare him to submit a successful F31 application at the end of the supplement.