Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

将中风后处理速度的提高转移到日常认知任务中

• 批准号: 10682264
• 负责人: Edward Taub
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682264
• 关键词: Address; Adult; Aftercare; Applications Grants; Basic Science; Behavioral; Clinical Research; Cognitive; Cognitive Therapy; Combined Modality Therapy; Data; Data Analyses; Development; Fostering; Funding; Grant; Impaired cognition; Impairment; Intervention; Life; Manuscripts; Measures; Methods; Participant; Patients; Performance; Process; Randomized, Controlled Trials; Rehabilitation therapy; Request for Applications; Research; Research Activity; Research Personnel; Scientist; Single-Blind Study; Site; Speed; Stroke; Structure; Techniques; Training; Writing; arm; career; chronic stroke; cognitive task; constraint induced movement therapy; constraint induced therapy; design; efficacy evaluation; improved; information processing; instrumental activity of daily living; neurological rehabilitation; new combination therapies; parent grant; post stroke; processing speed; programs; skills; symposium; treatment effect

ABSTRACT This Diversity Supplement application is connected to funded grant R01 AG070049 (Title: Transferring Speed of Processing Gains to Everyday Life; PI: E. Taub; Project Period: 9/5/2021- 8/31/2022). This application requests funds to provide training in neurorehabilitation research to the proposed Diversity Supplement candidate in association with the clinical study supported by the parent grant. The purpose of the parent grant is to conduct a randomized controlled trial (RCT) to evaluate the efficacy of a new treatment, Constraint-Induced (CI) Cognitive Therapy, for improving cognitive impairment in patients with chronic stroke. CI Cognitive Therapy combines two repeatedly validated rehabilitation methods: the Transfer Package of CI Movement Therapy and Speed of Cognitive Processing Training. The purpose of doing so is to produce a marked enhancement in the transfer of cognitive improvement from the training setting to instrumental activities of daily living (IADL) in everyday situations. Both halves of the new combination therapy are founded on the investigators’ own basic research. In both cases, efficacy is supported by positive results from multiple single-site RCTs and a large multisite RCT. However, the effect of Speed of Processing Training (SOPT) has been found to have limited generalization to cognitive-based IADL in everyday situations. In contrast, one of the main strengths of CI Therapy is that it produces a robust and extensive transfer of treatment effect to everyday life situations by means, in part, of its Transfer Package (TP). The parent grant involves a single-blind RCT with two arms: SOPT with the TP vs. SOPT without the TP. Participants will be 120 adults more than 1-year post-stroke with mild to moderate cognitive impairment. Performance on cognitive tasks will be measured in daily life and in the lab before and after baseline, after treatment, and 6- and 12-months afterwards. To expand the research skills of the Diversity Supplement candidate and foster her development as a career as an independent scientist, this application proposes a two-year, structured program of didactic training in grant writing and data analysis, hands-on training in the design and conduct of neuro-rehabilitation research, independent research activity, manuscript and grant application development, and presentation of data at scientific conferences.

抽象的 该多样性补充申请与资助赠款 R01 AG070049（标题：转移 日常生活中处理速度的提高； PI：E.陶布；项目期限：2021年9月5日至2022年8月31日）。这 申请要求资金为拟议的多样性提供神经康复研究培训 与家长资助支持的临床研究相关的补充候选人。 家长资助的目的是进行随机对照试验（RCT）来评估 约束诱导（CI）认知疗法这一新疗法对于改善认知障碍的疗效 慢性中风患者。 CI 认知疗法结合了两种经过反复验证的康复方法： CI运动疗法转移包和认知处理训练速度。目的 这样做是为了显着增强训练环境中认知改善的转移 日常生活中的工具性日常生活活动（IADL）。新组合的两半 治疗建立在研究者自己的基础研究之上。在这两种情况下，疗效均得到积极的支持 来自多个单中心随机对照试验和一个大型多中心随机对照试验的结果。然而，处理速度的影响 研究发现，训练 (SOPT) 对日常情况下基于认知的 IADL 的泛化能力有限。 相比之下，CI 疗法的主要优势之一是它能产生强大而广泛的转移 部分通过其转移包（TP）对日常生活情况产生治疗效果。 家长资助涉及单盲 RCT，有两个组：带有 TP 的 SOPT 与不带 TP 的 SOPT TP。参与者将是 120 名中风后 1 年以上患有轻度至中度认知障碍的成年人。 认知任务的表现将在基线之前和之后、之后在日常生活和实验室中进行测量 治疗后以及治疗后 6 个月和 12 个月。 扩大多样性补充候选人的研究技能并促进她作为一名 作为一名独立科学家的职业生涯，该应用程序提出了为期两年的结构化教学培训计划 资助写作和数据分析，神经康复研究设计和实施的实践培训， 独立研究活动、手稿和资助申请开发以及数据呈现 科学会议。