Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

将中风后处理速度的提高转移到日常认知任务中

• 批准号: 10682264
• 负责人: Edward Taub
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682264
• 关键词: Address; Adult; Aftercare; Applications Grants; Basic Science; Behavioral; Clinical Research; Cognitive; Cognitive Therapy; Combined Modality Therapy; Data; Data Analyses; Development; Fostering; Funding; Grant; Impaired cognition; Impairment; Intervention; Life; Manuscripts; Measures; Methods; Participant; Patients; Performance; Process; Randomized, Controlled Trials; Rehabilitation therapy; Request for Applications; Research; Research Activity; Research Personnel; Scientist; Single-Blind Study; Site; Speed; Stroke; Structure; Techniques; Training; Writing; arm; career; chronic stroke; cognitive task; constraint induced movement therapy; constraint induced therapy; design; efficacy evaluation; improved; information processing; instrumental activity of daily living; neurological rehabilitation; new combination therapies; parent grant; post stroke; processing speed; programs; skills; symposium; treatment effect

ABSTRACT This Diversity Supplement application is connected to funded grant R01 AG070049 (Title: Transferring Speed of Processing Gains to Everyday Life; PI: E. Taub; Project Period: 9/5/2021- 8/31/2022). This application requests funds to provide training in neurorehabilitation research to the proposed Diversity Supplement candidate in association with the clinical study supported by the parent grant. The purpose of the parent grant is to conduct a randomized controlled trial (RCT) to evaluate the efficacy of a new treatment, Constraint-Induced (CI) Cognitive Therapy, for improving cognitive impairment in patients with chronic stroke. CI Cognitive Therapy combines two repeatedly validated rehabilitation methods: the Transfer Package of CI Movement Therapy and Speed of Cognitive Processing Training. The purpose of doing so is to produce a marked enhancement in the transfer of cognitive improvement from the training setting to instrumental activities of daily living (IADL) in everyday situations. Both halves of the new combination therapy are founded on the investigators’ own basic research. In both cases, efficacy is supported by positive results from multiple single-site RCTs and a large multisite RCT. However, the effect of Speed of Processing Training (SOPT) has been found to have limited generalization to cognitive-based IADL in everyday situations. In contrast, one of the main strengths of CI Therapy is that it produces a robust and extensive transfer of treatment effect to everyday life situations by means, in part, of its Transfer Package (TP). The parent grant involves a single-blind RCT with two arms: SOPT with the TP vs. SOPT without the TP. Participants will be 120 adults more than 1-year post-stroke with mild to moderate cognitive impairment. Performance on cognitive tasks will be measured in daily life and in the lab before and after baseline, after treatment, and 6- and 12-months afterwards. To expand the research skills of the Diversity Supplement candidate and foster her development as a career as an independent scientist, this application proposes a two-year, structured program of didactic training in grant writing and data analysis, hands-on training in the design and conduct of neuro-rehabilitation research, independent research activity, manuscript and grant application development, and presentation of data at scientific conferences.

摘要 此多样性补充申请与基金资助R01 AG070049(标题：转移 处理速度提高到日常生活；PI：E.Taub；项目期：2021年9月5日-2022年8月31日)。这 申请申请资金，为拟议的多样性提供神经康复研究方面的培训 与父母资助的临床研究相关的补充候选人。 父母赠款的目的是进行一项随机对照试验(RCT)来评估 一种新的治疗方法--强制诱导(CI)认知疗法改善儿童认知功能障碍的疗效 慢性中风患者。CI认知疗法结合了两种反复验证的康复方法： CI运动疗法与认知加工速度训练的转换包目的 这样做是为了在从培训环境中迁移认知改进方面产生显著的增强 日常生活中的工具性活动(IADL)。新组合的两个部分 治疗是建立在研究人员自己的基础研究之上的。在这两种情况下，疗效都得到了积极的支持 来自多个单站点随机对照试验和大型多站点随机对照试验的结果。然而，处理速度的影响 训练(SOPT)被发现在日常情况下对基于认知的IADL的概括有限。 相比之下，CI疗法的主要优势之一是它产生了强大而广泛的 治疗效果的日常生活情况，部分是通过其转移包装(TP)。 父授权涉及具有两个臂的单盲RCT：带TP的SOPT与不带TP的SOPT TP.参与者将是120名中风后1年以上患有轻度至中度认知障碍的成年人。 认知任务的表现将在日常生活和实验室中在基线前后、之后进行测量 治疗后6个月和12个月。 拓展多样性副刊候选人的研究技能，促进她作为 作为一名独立科学家的职业生涯，这份申请提出了一个为期两年的有组织的教学培训计划 在赠款撰写和数据分析方面，在神经康复研究的设计和实施方面进行实践培训， 独立研究活动、手稿和赠款申请的开发，以及在 科学会议。