Randomized Controlled Trial of Pediatric CI Therapy

儿科 CI 治疗的随机对照试验

基本信息

批准号：
7107153
负责人：
Edward Taub
金额：
$ 32.56万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-04 至 2008-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The overall objective of this research is to test the efficacy of a new form of pediatric rehabilitation therapy -namely, Pediatric CI therapy - to promote new and improved motor behavior in young children with hemiparesis associated with cerebral palsy. This is based on a theoretically-grounded therapy shown to be effective with adult patients with chronic stroke and to produce cortical reorganization (cf. Taub et al., 1993; Liepert et al., 2000). Pediatric Cl therapy involves (1) total restraint of the unaffected upper extremity and (2) repetitive use of the affected extremity, using intensive shaping procedures for 6 hours/day for 21 consecutive days. The proposed research builds on findings from a preliminary study that demonstrated significant gains in young children's upper extremity skills following Pediatric Cl therapy. We propose to conduct a prospective, randomized controlled study with 52 children (ages 2-6) with hemiparetic cerebral palsy. The specific aims are:(1) to test the efficacy of Pediatric Cl therapy compared to Conventional therapy to improve upper extremity movement and functional use;(2) to evaluate whether improvement (if detected) is sustained over the next 12 months; and(3) to assess whether Pediatric Cl therapy is associated with significant gains in other adaptive behavior domains (e.g., trunk control, mobility, communication, and self-help skills).This research is of paramount significance because there currently are no forms of pediatric rehabilitation proven efficacious (Barry, 2001), despite widespread use of physical and occupational therapy in treatment of young children with cerebral palsy (Ramey et al; 2000).

描述（由申请人提供）：这项研究的总体目的是测试一种新形式的小儿康复疗法的疗效 - 即儿科CI疗法 - 促进与大脑麻痹相关的偏瘫儿童的新运动和改善运动行为。这是基于一种理论上的疗法，该疗法显示出对成年慢性中风患者有效并产生皮质重组（参见Taub等，1993; Liepert等，2000）。儿科CL疗法涉及（1）使用不受影响的上肢的总约束，以及（2）连续21天使用6小时/天的强化塑形程序，重复使用受影响的肢体。拟议的研究基于一项初步研究的发现，该研究表明，小儿CL疗法后，幼儿的上肢技能取得了显着增长。我们建议对52名儿童（2-6岁）进行脑膜脑瘫。具体目的是：（1）与常规疗法相比，测试小儿CL疗法的功效，以改善上肢运动和功能使用；（2）评估未来12个月内是否持续改善（如果检测到）；（3）评估儿科CL疗法是否与其他适应性行为领域的显着增长有关（例如，躯干控制，流动性，沟通和自助技能）。这项研究具有至关重要的意义，因为目前尚无儿科康复的形式，尽管有证明的儿童康复能力证明了疗效（Barry，2001年），尽管在物理和占用的治疗中都没有养育良好的治疗方法，该疗法是在物理疗法中使用的，该疗法是在物理疗法中的繁殖疗法，该疾病的年轻人（曾经是曾经是曾经是曾经是曾经的曾经是曾经是曾经是曾经占用的治疗）的方法Al;