权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond Integrity

肽-聚合物工程牙本质/粘合剂界面结合完整性

基本信息

批准号：
10681489
负责人：
Paulette Spencer
金额：
$ 35.98万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-12 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10681489
关键词：
Acids Address Adhesives Adult Amalgam Anti-Bacterial Agents Bacteria Biodegradation Characteristics Child Clinical Composite Resins Data Dental Care Dentin Deterioration Engineering Environment Enzymes Failure Feedback Fracture Hydrolysis In Situ Infiltration Injury Liquid substance Longevity Measurement Mechanics Mediating Microbial Biofilms Modeling Oral Oral cavity Patients Peptides Performance Plant Resins Polymer Chemistry Polymers Process Proliferating Property Psychological reinforcement Recurrence Resistance Risk Secondary to Streptococcus mutans Structure System Tissues Tooth Loss Tooth structure Virulence Viscosity antimicrobial cariogenic bacteria chemical property composite restoration demineralization design high risk improved in vivo interfacial mechanical properties meetings monomer novel predictive modeling remineralization repaired restoration restorative material seal

项目摘要

Project Summary The cycle of repeated composite-restoration replacements is a pernicious problem—each replacement risks pulpal injury, increased tooth weakness, and eventually, tooth loss. The problem is pervasive—nearly 70% of all composite restorations are replacements and the leading cause of failure is recurrent marginal decay. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the material/tooth interface. The adhesive that bonds the composite to the tooth is intended to seal the interface, but the adhesive seal to dentin is fragile—it is readily damaged by acids, enzymes, and other oral fluids. Bacteria and bacterial by-products infiltrate the resulting marginal gaps, demineralize and decompose the tooth, and further erode the adhesive, leading to wider and deeper gaps that create an ideal environment for bacteria to proliferate. Biodegradation by- products accumulate at the dentin/adhesive interface and increase the virulence of cariogenic bacteria, provoking a positive feedback loop that escalates the degradation. There is an urgent need to address this composite/tooth-interface vulnerability through multi-factorial approaches that: i) remineralize damaged dentin; ii) inhibit bacterial attack; and iii) provide durable polymers. Recent findings from our lab offer significant promise for meeting this need. First, we have synthesized novel self-strengthening polymers—the self-strengthening mechanism provides a persistent, intrinsic reinforcement of the polymer network in both neutral and acidic conditions. We have engineered antimicrobial and remineralizing peptides and tethered them to self- strengthening-adhesive monomers. Building on our progress, we propose to use both engineered peptides and antibacterial agents tethered to novel polymers to provide a “bio-hybrid” adhesive that will serve as a durable barrier to recurrent decay. Our threefold strategy exploits: (i) polymer-tethered engineered peptides and antibacterial agents to simultaneously provide antibacterial activity, delay biofilm formation, and remineralize dentin; (ii) self-strengthening polymers that resist hydrolysis-mediated degradation; and (iii) iterative feedback between synthesis, characterization, and modeling to forecast performance under relevant in vivo conditions.

项目总结

项目成果

期刊论文数量（35）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Development of methacrylate/silorane hybrid monomer system: Relationship between photopolymerization behavior and dynamic mechanical properties.

甲基丙烯酸酯/硅氧烷杂化单体体系的开发：光聚合行为与动态机械性能之间的关系。

DOI：
10.1002/jbm.b.33435
发表时间：
2016
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
0
作者：
Song,Linyong;Ye,Qiang;Ge,Xueping;Singh,Viraj;Misra,Anil;Laurence,JenniferS;Berrie,CindyL;Spencer,Paulette
通讯作者：
Spencer,Paulette

Effect of Partition of Photo-initiator Components and Addition of Iodonium Salt on the Photopolymerization of Phase-Separated Dental Adhesive.