Study of Latinos (SOL) Ojos

项目摘要/摘要 这项申请建议对西班牙裔社区健康研究/拉美裔研究进行辅助眼科研究 (六六六/悬浮物)。HCHS/SOL是一个预期的、以人口为基础的多中心队列，由国家心脏资助， 肺、血液研究所(NHLBI)和其他6个国家卫生研究院(NIH)，旨在 1)评估疾病负担；以及2)解决心血管疾病(CVD)、中风、哮喘、慢性阻塞性疾病 肺部疾病，睡眠障碍，龋齿和牙周病，听力障碍，糖尿病， 肾脏和肝脏疾病，以及认知障碍。这项里程碑式的研究是 拉美裔/拉美裔构成了广泛、高质量的表型和基因分型数据的全国性资源。 参与者包括墨西哥人、古巴人、多米尼加人、波多黎各人、中美洲和南美洲人以及 其他来源。HSHC/SOL招募了16,415名参与者参加访问#1(2008-2011年)；访问#2收集数据 (2014-2017)12/17年度结束(芝加哥和迈阿密球场中心：参与率：82.3%)；以及，NHLBI 签约HCHS/SOL访问#3(2019-2022年)资金，作为辅助研究的平台。我们将招募 并对来自芝加哥和迈阿密的2,500名HCHS/SOL参与者进行了详细的眼部检查，年龄在≥40岁至 与访问3同时进行。HCHS/SOL协调中心将在过度抽样老年人方面提供指导 为了最大限度地提高疾病检测效率，使用反映选择概率的抽样权重来保持 准确的流行率。具有不同背景的拉丁裔，如HCHS/SOL，代表着丰富的社会文化和 一个基因混合的群体，继承了欧洲人、美洲原住民和非洲人的混合血统 以前与世隔绝的种群。因此，HCHS/Sol Eye研究将代表第一个高度混合的眼睛 流行病学队列。这种在基础和临床研究中必不可少的异质性和内在变异性， 创新性地将HCHS/Sol Eye研究定位为在流行风险中评估重要的病因途径 不能用同类队列评估的因素和结果。我们建议收集高质量的 眼睛结果数据，与国家眼科研究所(NEI)资助的基于人群的队列相同，这将允许 眼科流行病学社区首次评估与系统性疾病相关的新假说 疾病在一个特征良好的、多样化的队列中。HCHS/SOL眼科研究旨在1)评估和 比较西班牙裔/拉丁裔群体2010年年龄标准化慢性眼病患病率 使用以前建立的六氯环己烷/SOL“基因分析小组”(内地：墨西哥人、中环和墨西哥人 南美洲；和加勒比：古巴人、多米尼加人和波多黎各人)；以及2)评估 流行疾病与新的心血管疾病、生物医学和社会文化风险因素有关。建议 研究利用NHLBI资助的流行病学研究，由其他6个NIH研究所支持，并代表 对于高度创新和高效的流行病学眼科研究来说，这是一个重大机遇。

PROJECT SUMMARY/ABSTRACT This application proposes an ancillary eye study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a prospective, population-based, multicenter cohort, funded by the National Heart, Lung, and Blood Institute (NHLBI) and 6 other National Institutes of Health (NIH) Institutes, that is designed to 1) assess disease burden; and, 2) address cardiovascular disease (CVD), stroke, asthma, chronic obstructive pulmonary disease, sleep disorders, dental caries and periodontal disease, hearing impairment, diabetes, kidney and liver disease, and cognitive impairment. This landmark study, the largest ever conducted in Hispanics/Latinos, constitutes a national resource of extensive, high-quality phenotypic and genotypic data. Participants include those of Mexican, Cuban, Dominican, Puerto Rican, Central and South American, and Other origins. HSHC/SOL recruited 16,415 participants for Visit #1 (2008-2011); data collection for Visit #2 (2014-2017) concluded 12/17 (Chicago and Miami Field Centers: 82.3% participation rate); and, NHLBI contracted HCHS/SOL Visit #3 (2019-2022) funding to serve as a platform for ancillary studies. We will recruit and perfom a detailed eye exam on 2500 HCHS/SOL participants from Chicago and Miami aged ≥40 years to coincide with Visit #3. The HCHS/SOL Coordinating Center will provide direction in oversampling older adults to maximize disease detection efficiency, with sampling weights reflecting probabilities of selection to maintain accurate prevalence rates. Latinos of diverse backgrounds as in HCHS/SOL represent a rich sociocultural and genetically admixed group, inheriting a mixture of European, Native American, and African ancestry from populations previously isolated. As such, the HCHS/SOL Eye Study will represent the first highly admixed eye epidemiology cohort. This heterogeneity and intrinsic variability, essential in basic and clinical research, innovatively positions the HCHS/SOL Eye Study to assess important etiologic pathways amid prevalent risk factors and outcomes that cannot be assessed with homogenous cohorts. We propose to collect high-quality eye outcome data, identical to National Eye Institute (NEI)-funded population-based cohorts, which will allow the eye epidemiology community to, for the first time, assess novel hypotheses associated with systemic disease in a well-characterized, diverse cohort. The HCHS/SOL Eye Study is designed to 1) assess and compare the 2010 age-standardized prevalence of chronic eye disease across Hispanic/Latino groups using previously constructed HCHS/SOL “genetic analysis groups” (Mainland: Mexicans, Central and South Americans; and, Caribbean: Cubans, Dominicans, and Puerto Ricans); and, 2) assess whether prevalent disease is associated with novel CVD, biomedical, and sociocultural risk factors. Proposed research leverages NHLBI-funded epidemiologic research supported by 6 other NIH Institutes, and represents a significant opportunity for highly innovative and efficient epidemiologic eye research.