Study of Latinos (SOL) Ojos

拉丁裔研究 (SOL) 奥霍斯

• 批准号: 10232086
• 负责人: CHARLOTTE E JOSLIN
• 金额: $ 249.27万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10232086
• 关键词: Acculturation; Address; Admixture; Adult; African; African American; Age; Age related macular degeneration; American; Ancillary Study; Aphorisms; Asthma; Basic Science; Biological; Blindness; Blood Pressure; Body mass index; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caribbean region; Cataract; Censuses; Central American; Characteristics; Chicago; Chinese American; Chronic; Chronic Obstructive Airway Disease; Clinical Research; Cohort Studies; Communities; Community Surveys; Contact Lenses; Contracts; Cuban; Data; Data Collection; Dental caries; Detection; Diabetes Mellitus; Diabetic Retinopathy; Disabled Persons; Disease; Dominican; Elderly; Epidemiology; Ethnic group; Etiology; European; Eye; Eye diseases; Funding; Future; Genetic; Genotype; Glaucoma; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Hispanics; Impaired cognition; Inherited; Institutes; Kidney Diseases; Knowledge; Latino; Life Style; Lipids; Liver diseases; Los Angeles; Macular degeneration; Mexican; Mexican Americans; National Eye Institute; National Heart, Lung, and Blood Institute; Native Americans; Open-Angle Glaucoma; Ophthalmic examination and evaluation; Outcome; Participant; Pathway interactions; Periodontal Diseases; Phenotype; Physical activity; Population; Positioning Attribute; Prevalence; Probability; Protocols documentation; Puerto Rican; Questionnaires; Reporting; Research; Research Design; Research Support; Resources; Risk Factors; Sampling; Serum; Sleep Disorders; South American; Standardization; Stroke; Structure; Study of Latinos; Systemic disease; Time; United States National Institutes of Health; Vision; Visit; Visual impairment; Weight; aged; blind; burden of illness; cohort; design; diabetic; epidemiology study; genetic analysis; hearing impairment; inflammatory marker; innovation; lymphotoxin beta; novel; population based; prevent; prospective; racial and ethnic; recruit; social culture; sociodemographics

PROJECT SUMMARY/ABSTRACT This application proposes an ancillary eye study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a prospective, population-based, multicenter cohort, funded by the National Heart, Lung, and Blood Institute (NHLBI) and 6 other National Institutes of Health (NIH) Institutes, that is designed to 1) assess disease burden; and, 2) address cardiovascular disease (CVD), stroke, asthma, chronic obstructive pulmonary disease, sleep disorders, dental caries and periodontal disease, hearing impairment, diabetes, kidney and liver disease, and cognitive impairment. This landmark study, the largest ever conducted in Hispanics/Latinos, constitutes a national resource of extensive, high-quality phenotypic and genotypic data. Participants include those of Mexican, Cuban, Dominican, Puerto Rican, Central and South American, and Other origins. HSHC/SOL recruited 16,415 participants for Visit #1 (2008-2011); data collection for Visit #2 (2014-2017) concluded 12/17 (Chicago and Miami Field Centers: 82.3% participation rate); and, NHLBI contracted HCHS/SOL Visit #3 (2019-2022) funding to serve as a platform for ancillary studies. We will recruit and perfom a detailed eye exam on 2500 HCHS/SOL participants from Chicago and Miami aged ≥40 years to coincide with Visit #3. The HCHS/SOL Coordinating Center will provide direction in oversampling older adults to maximize disease detection efficiency, with sampling weights reflecting probabilities of selection to maintain accurate prevalence rates. Latinos of diverse backgrounds as in HCHS/SOL represent a rich sociocultural and genetically admixed group, inheriting a mixture of European, Native American, and African ancestry from populations previously isolated. As such, the HCHS/SOL Eye Study will represent the first highly admixed eye epidemiology cohort. This heterogeneity and intrinsic variability, essential in basic and clinical research, innovatively positions the HCHS/SOL Eye Study to assess important etiologic pathways amid prevalent risk factors and outcomes that cannot be assessed with homogenous cohorts. We propose to collect high-quality eye outcome data, identical to National Eye Institute (NEI)-funded population-based cohorts, which will allow the eye epidemiology community to, for the first time, assess novel hypotheses associated with systemic disease in a well-characterized, diverse cohort. The HCHS/SOL Eye Study is designed to 1) assess and compare the 2010 age-standardized prevalence of chronic eye disease across Hispanic/Latino groups using previously constructed HCHS/SOL “genetic analysis groups” (Mainland: Mexicans, Central and South Americans; and, Caribbean: Cubans, Dominicans, and Puerto Ricans); and, 2) assess whether prevalent disease is associated with novel CVD, biomedical, and sociocultural risk factors. Proposed research leverages NHLBI-funded epidemiologic research supported by 6 other NIH Institutes, and represents a significant opportunity for highly innovative and efficient epidemiologic eye research.

项目概要/摘要 本申请提议对西班牙裔社区健康研究/拉丁裔研究进行辅助眼科研究 （HCHS/SOL）。 HCHS/SOL 是一个基于人群的前瞻性多中心队列，由国家心脏中心资助， 肺和血液研究所 (NHLBI) 以及其他 6 个国立卫生研究院 (NIH) 研究所，旨在 1）评估疾病负担； 2) 解决心血管疾病 (CVD)、中风、哮喘、慢性阻塞性肺疾病 肺部疾病、睡眠障碍、龋齿和牙周病、听力障碍、糖尿病、 肾脏和肝脏疾病以及认知障碍。这项具有里程碑意义的研究是有史以来规模最大的研究 西班牙裔/拉丁裔构成了广泛、高质量的表型和基因型数据的国家资源。 参与者包括墨西哥、古巴、多米尼加、波多黎各、中美洲和南美洲以及 其他起源。 HSHC/SOL 招募了 16,415 名参与者进行第 1 次访问（2008-2011 年）；访问 #2 的数据收集 （2014-2017）12/17 结束（芝加哥和迈阿密场地中心：82.3% 参与率）；和，NHLBI 签订了 HCHS/SOL Visit #3 (2019-2022) 资助合同，作为辅助研究的平台。我们将招募 对来自芝加哥和迈阿密的 2500 名年龄≥40 岁的 HCHS/SOL 参与者进行详细的眼部检查 与访问 #3 一致。 HCHS/SOL 协调中心将为老年人过度抽样提供指导 最大限度地提高疾病检测效率，采样权重反映选择概率以维持 准确的患病率。 HCHS/SOL 中具有不同背景的拉丁裔代表了丰富的社会文化和 基因混合群体，继承了欧洲、美洲原住民和非洲血统的混合体 之前被隔离的人群。因此，HCHS/SOL 眼科研究将代表第一个高度混合的眼科研究 流行病学队列。这种异质性和内在变异性对于基础和临床研究至关重要， 创新性地定位 HCHS/SOL 眼科研究，以评估普遍风险中的重要病因途径 无法用同质队列评估的因素和结果。我们建议收集高质量 眼部结果数据与国家眼科研究所 (NEI) 资助的基于人群的队列相同，这将允许 眼流行病学界首次评估与系统性眼病相关的新假设 疾病存在于一个特征明确、多样化的队列中。 HCHS/SOL 眼科研究旨在 1) 评估和 比较 2010 年西班牙裔/拉丁裔群体慢性眼病的年龄标准化患病率 使用先前构建的 HCHS/SOL“遗传分析组”（大陆：墨西哥人、中部和 南美洲；加勒比地区：古巴人、多米尼加人和波多黎各人）；以及，2) 评估是否 流行疾病与新的心血管疾病、生物医学和社会文化危险因素相关。建议的 研究利用 NHLBI 资助的流行病学研究，并得到其他 6 个 NIH 研究所的支持，并代表 这是高度创新和高效的流行病学眼科研究的重要机会。