NICHD Neonatal Research Network (NRN)

NICHD 新生儿研究网络 (NRN)

• 批准号: 10682973
• 负责人: Pablo J Sanchez
• 金额: $ 1.56万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682973
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Behavioral; Board Certification; Bronchopulmonary Dysplasia; Cardiology; Child; Childhood; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Cognitive; Collaborations; Communicable Diseases; Consent; Dedications; Discipline of obstetrics; Disparity; Doctor of Philosophy; Eligibility Determination; Enrollment; Ensure; Evaluation; Family; Funding; Goals; Healthcare; Hospitals; Individual; Infant; Infant Care; Intensive Care Units; International; Intervention; Joints; Lactation; Leadership; Longitudinal Studies; Low Birth Weight Infant; Maternal-Fetal Medicine Units Network; Medical; Medicine; Methodist Church; Mission; Multi-Institutional Clinical Trial; Multi-site clinical study; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Neonatology; Neurology; Newborn Infant; Observational Study; Ohio; Outcome; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Performance; Perinatal; Positioning Attribute; Premature Birth; Premature Infant; Principal Investigator; Productivity; Protocols documentation; Recording of previous events; Referral and Consultation; Reproducibility; Research; Research Design; Research Infrastructure; Research Institute; Research Support; Role; Safety; Source; Study Subject; Treatment Efficacy; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Vision; Work; antimicrobial; clinical care; clinical infrastructure; clinical practice; cultural equity; data acquisition; experience; extreme prematurity; feeding; fetal; follow-up; health equity; high risk infant; improved; infant morbidity; infant morbidity/mortality; innovation; neonatal care; neonatal patient; neonate; opioid exposure; patient population; pediatric department; perinatal medicine; programs; randomized trial; randomized, clinical trials; recruit; research study; systems research

PROJECT SUMMARY/ABSTRACT This proposal is a renewal application from the Division of Neonatology at Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU) to participate with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under a cooperative agreement (RFA: HD-16-020) in an ongoing multicenter clinical research program entitled the Neonatal Research Network (NRN). NCH/OSU was selected in 2011 to become one of 18 academic centers of the NRN. In 2016, NCH/OSU along with an additional affiliated neonatal intensive care unit (NICU) at Riverside Methodist Hospital (RMH) was again selected as one of the 15 centers that currently comprise the NRN. The Division of Neonatology has demonstrated a strong commitment to the NRN and will continue to support and enhance this network. Pablo Sánchez, MD, Jonathan Slaughter, MD, MPH, and Kristen Benninger, MD, MSc, are the Principal Investigator (PI), Alternate PI, and Follow-up PI, respectively. Dr. Sánchez has extensive experience in the performance of multicenter, randomized clinical trials. By being board certified in both Neonatology and Pediatric Infectious Diseases, he will provide expertise to the NRN on issues in neonatal infectious diseases and antimicrobial stewardship, vexing problems in the NICU. Dr. Slaughter has extensive experience in clinical research including clinical trial and advanced observational study design, while Dr. Benninger studies the long term outcomes of opioid-exposed infants. The Specific Aim of this proposal is to conduct multicenter clinical trials and observational studies in neonatal medicine in order to reduce infant morbidity and mortality and promote healthy outcomes. With the strong support of the Pediatric Department and Hospitals, NCH-OSU-RMH has the necessary academic and innovative clinical and research infrastructure to ensure continued excellence in the performance of NRN studies. Our Neonatology Division has a long-standing dedication to improving patient outcomes with a strong focus on health equity. We have developed innovative signature clinical programs in extreme prematurity, bronchopulmonary dysplasia, infant feeding, neonatal infectious diseases/antimicrobial stewardship, acute kidney injury, neonatal cardiology, and neonatal neurology that have positively impacted patient outcomes and positioned us as a region- al/national/international referral and consultation center. In addition, the Obstetric Dept. at OSU is one of 12 centers of the NICHD Maternal-Fetal Medicine Units (MFMU), and strong collaboration exists between the OSU MFMU and NCH at all levels of clinical care and research. This ongoing partnership ensures a continued source of diverse patients for clinical studies. NCH-OSU-RMH has a proven track record within the NRN, as evidenced by its well organized clinical research program with a substantial percentage of eligible infants consented for randomized trials and excellence in study conduct and data acquisition. Follow-up of study infants is integrated within the large Follow-up Program at NCH, and follow-up rates of these infants remain excellent with substantial departmental and divisional support.

项目总结/摘要 此建议书是全国儿童医院新生儿科的续期申请书 和俄亥俄州州立大学（OSU）参加尤尼斯肯尼迪施莱佛国家儿童研究所 根据一项合作协议（RFA：HD-16 - 020）， 名为新生儿研究网络（NRN）的多中心临床研究计划。NCH/OSU被选中 2011年成为NRN的18个学术中心之一。2016年，NCH/OSU沿着与一个额外的附属机构 滨江卫理公会医院（RMH）的新生儿重症监护室（NICU）再次被选为15个 目前，NRN的中心。新生儿科表现出了坚定的承诺， 我们将继续支持和加强这一网络。巴勃罗桑切斯，医学博士，乔纳森斯劳特， 医学博士、公共卫生硕士和Kristen Benninger医学博士、理学硕士是主要研究者（PI）、替代PI和随访PI， 分别Sánchez博士在进行多中心、随机临床试验方面拥有丰富的经验。 通过在新生儿和儿科传染病委员会认证，他将提供专业知识， NRN关于新生儿传染病和抗菌药物管理问题，以及NICU中令人烦恼的问题。博士 Slaughter在临床研究方面拥有丰富的经验，包括临床试验和高级观察性研究 Benninger博士研究了阿片类药物暴露婴儿的长期结果。这一具体目标 建议在新生儿医学中进行多中心临床试验和观察性研究，以减少 并促进健康结果。在儿科的大力支持下， 部门和医院，NCH-OSU-RMH有必要的学术和创新的临床和研究 基础设施，以确保在NRN研究的性能持续卓越。我们的新生儿科 长期致力于改善患者治疗结果，并高度关注健康公平。我们有 在极早产、支气管肺发育不良、婴儿 喂养、新生儿感染性疾病/抗菌药物管理、急性肾损伤、新生儿心脏病学，以及 新生儿神经病学，积极影响病人的结果，并定位我们作为一个地区- al/国家/国际转诊和咨询中心。此外，产科部门。在俄勒冈州立大学， NICHD母胎医学单位（MFMU）的中心，以及OSU之间的强有力的合作 MFMU和NCH在各级临床护理和研究。这种持续的伙伴关系确保了 不同的患者进行临床研究。NCH-OSU-RMH在NRN内有着良好的记录， 通过其组织良好的临床研究计划，相当大比例的合格婴儿同意 随机试验和卓越的研究行为和数据采集。研究婴儿的随访是综合性的 在NCH的大型随访计划中，这些婴儿的随访率仍然很高， 部和司的支助。