Inclusion of sex and gender variables in musculoskeletal research and publications

摘要 性和性别影响健康的所有领域，包括肌肉骨骼健康。性和性别的例子- 基于肌肉骨骼健康的差异包括发展和治疗结果的风险， 骨质疏松症、骨关节炎和ACL损伤。然而，这些差异通常不会被考虑， 评估，或在已发表的文章中报告，如最近的几篇文献综述所示， 各种肌肉骨骼疾病缺乏对性和性别方面的考虑和公布的数据， 基于差异影响未来研究的发展，医疗保健专业人员的改进， 教育，并最终为男性，女性和变性患者提供护理质量。 我们计划召集一批活跃在性和性别领域的研究人员和《世界卫生组织》的编辑人员， 在肌肉骨骼医学和外科的主要科学杂志，以审查目前的研究状况 关于性和性别的影响。我们将讨论确保这些变量 在已发表的研究中得到适当考虑，并将评估各种选择和平台， 传达性和性别作为肌肉骨骼健康和疾病变量的重要性， 研究人员和期刊评审员。这次为期一天的会议的目标是目标的交叉点 美国国立卫生研究院妇女健康研究办公室，以推进研究“，以改善基本的 了解性和性别以及其他关键因素如何影响健康和疾病， 将这些知识扩展到转化和临床研究”以及NIAMS的研究，以“支持对 关节炎和肌肉骨骼.疾病的病因、治疗和预防”。 在会议结束时，可交付成果将是：（i）制定计划，以一致地评估适当的 在已发表的研究中纳入性和/或性别，包括评估采用SAGER或 类似的指导方针，并在期刊平台和审稿人之间传达这一点，ii）确定 从期刊到研究人员关于性和性别角色以及期望的沟通策略 考虑并将这些纳入提交的各种肌肉骨骼疾病的手稿中，以及iii） 在研究过程的早期探索与研究人员合作的机会，以确保性和性别是 在研究项目开发和数据分析计划中考虑。会议专题讨论会将在 发表在《骨与关节外科杂志》增刊上，并与NIAMS分享。

Abstract Sex and gender impact all areas of health, including musculoskeletal health. Examples of sex- and gender- based differences in musculoskeletal health include risks for developing and treatment outcomes of osteoporosis, osteoarthritis, and ACL injuries. However, these differences are not routinely considered, assessed, or reported in published articles, as demonstrated in several recent reviews of the literature for various musculoskeletal conditions. The lack of consideration and published data regarding sex- and gender- based differences impacts the development of future research, improvement in healthcare professional education, and ultimately the quality of care for men, women, and transgender patients. We plan to assemble a group of researchers active in the area of sex and gender and the editorial staffs of the major scientific journals in musculoskeletal medicine and surgery to review the current status of research regarding the impacts of sex and gender. We will discuss the need to assure that these variables are appropriately considered in published research and will also assess options and platforms through which to communicate the importance of sex and gender as variables in musculoskeletal health and disease to investigators and journal reviewers. The goals of this one-day meeting at the intersection of the goals of goals of the NIH Office of Research on Women’s Health to advance research “to improve the fundamental understanding of how sex and gender, among other critical factors, influence health and disease, and to extend this knowledge to translational and clinical studies” and those of NIAMS to “support research into the causes, treatment, and prevention of arthritis and musculoskeletal… diseases”. At the end of the meeting, the deliverables will be to (i) develop plans to consistently assess for the appropriate inclusion of sex and/or gender in published research, including evaluating the role for adopting SAGER or similar guidelines, and to communicate this across journal platforms and to reviewers, ii) identify communication strategies from journals to investigators about the roles of sex and gender and the expectations for consideration and inclusion of these in submitted manuscripts across musculoskeletal conditions, and iii) explore opportunities to work with researchers early in the study process to assure that sex and gender are considered in research project development and plans for data analysis. The meeting symposia will be published in a Journal of Bone and Joint Surgery supplement and shared with NIAMS.