2023 RNA Editing Gordon Research Conference and Gordon Research Seminar

项目摘要 关于RNA编辑的GRC是致力于核酸修饰的主要国际会议。这个 2023年会议的副标题是：“跨生物系统的RNA/DNA编辑和表位转录组学”。修改 对于在DNA和RNA中发现的常见核苷，人们已经知道很多年了。然而，最近 检测它们的分析技术的进展，以及对其广泛影响的更深入了解 这些改变对包括人类疾病在内的基本生物过程造成了 文艺复兴在他们的书房里。事实上，我们现在知道，核酸修饰在各种情况下都很常见 天然存在的核酸，影响基因表达、蛋白质合成、认知、先天和 适应性免疫、自身免疫性疾病和癌症。此外，几个研究实验室已经改变了用途 自然编辑RNA或DNA碱基以进行定向基因组编辑的酶。这次会议将带来 聚集了一群拥有不同专业知识的不同科学家，他们的共同目标是分享想法和 可以促进我们对核酸修饰的许多方面的理解的方法。这 会议有三个具体目标。一是支持下一代科学技术产业发展 领袖们。实现这一目标的关键是支持随之而来的戈登研究研讨会(GRS)。在 在GRC前两天，将进行GRS，重点是交换研究数据和 编辑和修改领域的研究生和博士后的想法。我们的第二个具体目标是 促进DNA和RNA编辑和修饰方面的知识交流。在五天的GRC期间，有 每天下午大约有四个小时用于交流，有四个海报会议，46个演讲者和6个 演讲者从涵盖DNA和RNA编辑研究各个方面的摘要中挑选出来，以促进 跨学科和协作互动。我们的第三个目标是将学术研究人员与 工业界的利益相关者。基因编辑公司和生物医学科学公司的代表 编辑/修改焦点将参加2023年会议。这种互动将促进协作 与能够将基础健康相关研究带入下一阶段开发的公司或其他实验室合作 遗传病的治疗。

Project Summary The GRC on RNA editing is the premier international meeting dedicated to nucleic acid modifications. The 2023 meeting is subtitled: “RNA/DNA editing and epitranscriptomics across biological systems”. Modifications to the common nucleosides found in DNA and RNA have been known for many years. However, recent advances in analytical techniques for their detection, along with a deeper understanding of the broad impact these modifications have on fundamental biological processes, including human disease, have caused a renaissance in their study. Indeed, we now know that nucleic acid modifications are common in various naturally occurring nucleic acids and influence gene expression, protein synthesis, cognition, innate and adaptive immunity, autoimmune disease and cancer. Furthermore, several research labs have repurposed enzymes that naturally edit RNA or modify DNA bases for targeted genome editing. This meeting will bring together a diverse group of scientists with varying expertise with the common goal of sharing ideas and approaches that can advance our understanding of the many facets of nucleic acid modifications. This conference has three specific aims. First, we will support the development of the next generation of scientific leaders. Key to achieving this aim is supporting the accompanying Gordon Research Seminar (GRS). In the two days preceding the GRC, a GRS will take place that is focused on the exchange of research data and ideas among graduate students and post-docs in the editing and modification field. Our second specific aim is to facilitate knowledge exchange on DNA and RNA editing and modification. During the five day GRC, there is approximately four hours in each afternoon for networking, there are four poster sessions, 46 speakers and 6 speakers selected from abstracts covering all aspects of DNA and RNA editing research to foster interdisciplinary and collaborative interactions. Our third aim is to connect academic researchers to stakeholders in industry. Representatives of gene editing companies and biomedical science companies with an editing/modification focus will participate in the 2023 conference. This interaction will facilitate collaboration with companies or other labs that can take basic health related research to the next level of developing treatments for genetic diseases.