UC Davis Chemical Biology Program

加州大学戴维斯分校化学生物学项目

• 批准号: 10409717
• 负责人: PETER A. BEAL
• 金额: $ 26.52万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10409717
• 关键词: Biology; Chemicals; programs

The goal of the UC Davis Chemical Biology Program (CBP) is to provide effective cross training at the chemistry/biology interface for pre-doctoral candidates. After their CBP cross training, these students will understand the value of the synthesis and analysis tools traditionally associated with chemistry in addressing problems related to biological pathways, cells, tissues and organisms with a particular focus on biological questions related to human health. The chemical biology community at UC Davis includes a large group of productive, well funded and collaborative faculty members with a strong history of mentoring pre-doctoral students. The CBP faculty comprises 29 trainers with primary appointments in seven different departments in five different colleges. CBP faculty research programs cover a broad swath of topics (e.g. calcium signaling, glycobiology, metabolic engineering, DNA repair, RNA modification, translation, photoreception, photosynthesis, cancer therapeutics, drug metabolism, metabolomics, molecular imaging and genome editing) using an extensive range of approaches (e.g. genetics, genomics, x-ray crystallography, NMR spectroscopy, EPR spectroscopy, mass spectrometry, combinatorial chemistry, high throughput screening, computational modeling, enzymology and organic synthesis). Trainees will be selected for this program from first year students with an expressed interest in carrying out thesis research at the chemistry/biology interface from five different graduate groups (Chemistry; Biochemistry, Molecular, Cellular and Developmental Biology; Biomedical Engineering; Pharmacology and Toxicology and Biophysics). These students will engage in cross training coursework, cross training laboratory rotations, research-in-progress presentations, career development activities, responsible conduct in research training and annual retreats. This proposal requests support for six predoctoral student slots to support 3-4 trainees for two years each, typically during the second and third years of their PhD training. This support, along with the major institutional commitments made by UC Davis, will establish a predoctoral program that will more effectively prepare our trainees for scientific careers at the chemistry/biology interface.

加州大学戴维斯分校化学生物学计划（CBP）的目标是提供有效的交叉训练 在化学/生物学界面上为博士预科生准备的。在他们的CBP交叉训练后， 这些学生将理解传统的综合和分析工具的价值 与化学有关，解决与生物途径、细胞、组织有关的问题 特别关注与人类健康有关的生物学问题。 加州大学戴维斯分校的化学生物学社区包括一大群富有成效的，资金充足的 以及具有指导博士预科学生的悠久历史的合作教师。的 CBP教师包括29名培训师，主要任命在七个不同的部门， 五所不同的大学CBP教师的研究计划涵盖了广泛的主题（例如， 钙信号传导，糖生物学，代谢工程，DNA修复，RNA修饰， 翻译，光感受，光合作用，癌症治疗，药物代谢， 代谢组学，分子成像和基因组编辑）使用广泛的方法 (e.g.遗传学、基因组学、x射线晶体学、NMR光谱学、EPR光谱学、质谱 光谱分析，组合化学，高通量筛选，计算建模， 酶学和有机合成）。学员将从第一年开始被选中参加这个项目 有兴趣在化学/生物学进行论文研究的学生 来自五个不同研究生组的界面（化学;生物化学，分子，细胞和 发育生物学;生物医学工程;药理学和毒理学， 生物物理学）。这些学生将从事交叉培训课程，交叉培训实验室 轮换、研究进展报告、职业发展活动、负责 在研究培训和年度务虚会中进行。该提案要求支持六个 博士前学生名额，以支持3-4名学员，每两年，通常在第二年 和博士生的第三年这种支持，沿着主要的机构 加州大学戴维斯分校作出的承诺，将建立一个博士前计划，将更有效地 为我们的学员在化学/生物学界面的科学生涯做好准备。