UC Davis Training Program in Chemical Biology

 描述(由申请人提供)：加州大学戴维斯分校化学生物学项目(CBP)的目标是为博士前考生提供有效的化学/生物交叉培训。经过CBP交叉培训后，这些学生将理解传统上与化学有关的合成和分析工具在解决与生物途径、细胞、组织和生物体有关的问题方面的价值，特别是与人类健康有关的生物问题。加州大学戴维斯分校的化学生物学社区包括一大群富有成效、资金充足和合作的教职员工，他们有着指导博士生预科学生的丰富历史。CBP教员由29名培训员组成，他们的主要任务是在五所不同学院的六个不同系工作。CBP教员的研究项目涵盖广泛的主题(如钙信号、糖生物学、代谢工程、DNA修复、RNA修饰、翻译、光接收、光合作用、癌症治疗、药物代谢、代谢组学、分子成像和基因组编辑)，使用广泛的方法(如遗传学、基因组学、X射线结晶学、核磁共振波谱、EPR波谱、质谱学、组合化学、高通量筛选、计算建模、酶学和有机合成)。受训学生将从五个不同的研究生群体(化学、生物化学、分子、细胞和发育生物学、生物医学工程、药理学和毒理学以及生物物理学)中选择有兴趣在化学/生物界面进行论文研究的顶尖一年级学生。这些学生将参与交叉培训课程、交叉培训实验室轮换、研究进展报告、职业发展活动、负责任的研究培训和年度务虚会。该提案要求支持8个博士前学生时段，以支持4-5名学员，每个时段为期两年，通常是在博士培训的第二年和第三年期间。这一支持，以及加州大学戴维斯分校做出的重大机构承诺，将建立一个博士前项目，使我们的受训人员更有效地为化学/生物领域的科学生涯做好准备。

 DESCRIPTION (provided by applicant): The goal of the UC Davis Chemical Biology Program (CBP) is to provide effective cross training at the chemistry/biology interface for pre-doctoral candidates. After their CBP cross training, these students will understand the value of the synthesis and analysis tools traditionally associated with chemistry in addressing problems related to biological pathways, cells, tissues and organisms with a particular focus on biological questions related to human health. The chemical biology community at UC Davis includes a large group of productive, well-funded and collaborative faculty members with a strong history of mentoring pre-doctoral students. The CBP faculty comprises 29 trainers with primary appointments in six different departments in five different colleges. CBP faculty research programs cover a broad swath of topics (e.g. calcium signaling, glycobiology, metabolic engineering, DNA repair, RNA modification, translation, photoreception, photosynthesis, cancer therapeutics, drug metabolism, metabolomics, molecular imaging and genome editing) using an extensive range of approaches (e.g. genetics, genomics, x-ray crystallography, NMR spectroscopy, EPR spectroscopy, mass spectrometry, combinatorial chemistry, high throughput screening, computational modeling, enzymology and organic synthesis). Trainees will be selected for this program from the top first year students with an expressed interest in carrying out thesis research at the chemistry/biology interface from five different graduate groups (Chemistry; Biochemistry, Molecular, Cellular and Developmental Biology; Biomedical Engineering; Pharmacology and Toxicology and Biophysics). These students will engage in cross training coursework, cross training laboratory rotations, research-in-progress presentations, career development activities, responsible conduct in research training and annual retreats. This proposal requests support for eight predoctoral student slots to support 4-5 trainees for two years each, typically during the second and third years of their PhD training. This support, along with the major institutional commitments made by UC Davis, will establish a predoctoral program that will more effectively prepare our trainees for scientific careers at the chemistry/biology interface.