2023 Stem Cells and Cancer Gordon Research Conference and Seminar

项目摘要 该提案要求部分支持第八届戈登干细胞研究会议， 癌症，将于2023年5月14日至19日在卢卡（意大利）举行。本次会议的目标是提供一个 论坛的介绍，讨论和互动之间的一个多样化的，跨学科的研究小组， 对干细胞生物学、发育和癌症感兴趣。特别是，我们希望强调， 可用于更好地了解肿瘤的发生和转移。会议由 博士Cedric Blanpain（布鲁塞尔自由大学），与Leanne Jones博士（UCSF）和Kathrin普拉斯博士（UCLA） 担任副主席。计划的议程包括癌症领域的主要领导人的演讲 生物学，干细胞生物学和再生医学，因此将吸引一个高度跨学科的群体， 不经常在会议上互动的研究人员。因此，这次会议将成为新的催化剂， 当然，这也是戈登研究所的长期目标。 两会会议的杰出科学计划突出了贡献者的多样性 研究领域（48%的受邀演讲者是女性和/或代表性不足的少数群体成员）， 探讨了美国国立卫生研究院（NIH）特别感兴趣的前沿课题，包括但不限于 限于：已知调节干细胞命运决定和组织稳态的发育机制， 在肿瘤形成、代谢在调节干细胞中的作用、组织稳态和肿瘤中被篡夺。 生长和新兴疗法，以促进肿瘤细胞清除，根除肿瘤增殖干细胞， 增强器官修复。将从提交的摘要中选出更多的发言者，特别是 考虑到那些来自传统上在科学领域代表性不足的背景的研究人员。的 2023年戈登干细胞和癌症研究会议还将包括戈登研究研讨会 (GRS)，为期两天的“预备会议”，在一个高度刺激和包容的环境中， 促进信息的公开交流以及建立和发展同行网络。GRS将在 于2023年5月12日至13日在卢卡的同一地点举行，由Tugba Topal博士（密歇根大学）主持 由三名博士生组成的组委会支持：克拉拉·卡诺（加州大学洛杉矶分校），安德烈·佩雷斯 冈萨雷斯（布鲁塞尔自由大学）和尼古拉斯杰克逊（加州大学旧金山分校）。GRS提供额外的 初级学员有机会展示他们的工作，并获得重要的反馈和指导， 他们的同行和更成熟的调查人员，使这次会议成为一个特别有价值的培训 初级调查员的机会。一套具体的综合和互补的研究课题，将 在2023年干细胞和癌症GRS/GRC中解决的问题与其他会议不同， GRS和GRC的结构为不同领域的科学家和受训人员提供了富有成效的互动， 在工业界和学术界的职业生涯阶段，他们正在使用不同的方法解决该领域的基本问题， 实验方法。

PROJECT SUMMARY This proposal requests partial support for the eighth Gordon Research Conference on Stem Cells and Cancer, which will take place on May 14-19, 2023 in Lucca (Italy). The goal of this conference is to provide a forum for presentation, discussion and interaction among a diverse, interdisciplinary group of researchers with interests in stem cell biology, development, and cancer. In particular, we wish to highlight how principles taken from development can be used to better understand tumor initiation and metastasis. The meeting is chaired by Dr. Cedric Blanpain (Université Libre de Bruxelles), with Drs. Leanne Jones (UCSF) and Kathrin Plath (UCLA) serving as vice chairs. The planned agenda includes presentations from key leaders in the fields of cancer biology, stem cell biology and regenerative medicine, and thus will attract a highly interdisciplinary group of researchers who do not frequently interact at meetings. This meeting will, therefore, act as a catalyst for new collaborations and cross-fertilization of ideas, which is, of course, a long-term goal of the Gordon Research Conferences. The outstanding scientific program for the meeting highlights the diversity of contributors to this research area (48% of invited speakers are female and/or members of under-represented minority groups) and explores cutting-edge topics of particular interest to the National Institutes of Health (NIH), including but not limited to: developmental mechanisms known to regulate stem cell fate decisions and tissue homeostasis that are usurped for tumor formation, the role of metabolism in regulating stem cells, tissue homeostasis and tumor growth, and emerging therapies to promote tumor cell clearance, eradicate tumor-propagating stem cells and enhance organ repair. Additional speakers will be chosen from the submitted abstracts, with particular consideration given to those investigators from backgrounds traditionally underrepresented in the sciences. The 2023 Gordon Research Conference on Stem Cells and Cancer will also include a Gordon Research Seminar (GRS), a 2-day “pre-meeting” of early career scientists in a highly stimulating and inclusive environment that promotes the open exchange of information and establishment and growth of peer networks. The GRS will be held from May 12-13, 2023 at the same venue in Lucca, and is chaired by Dr. Tugba Topal (Univ. of Michigan) and supported by an organizing committee of three doctoral students: Clara Cano (UCLA), Andrea Pérez González (Université Libre de Bruxelles), and Nicholas Jackson (UCSF). The GRS provides additional opportunities for junior trainees to present their work and receive crucial feedback and mentorship both from their peers and from more established investigators, making this meeting a particularly valuable training opportunity for junior investigators. The specific set of integrated and complementary research topics that will be addressed in the 2023 Stem Cells and Cancer GRS/GRC is distinct from other conferences, and the unique structure of the GRS and GRC provides for productive interactions among scientists and trainees at different career stages in industry and academia who are addressing fundamental questions in the area using different experimental approaches.