Core B: Administrative Core

描述 管理核心将支持本计划的所有项目和生物信息学核心。项目PI的凯瑟琳·普拉斯将担任行政核心的负责人，由斯梅尔博士和扎雷特博士作为联合调查员提供支持。这一核心将通过为研究的定期规划、共享和评估提供结构和资金支持，使该计划的所有科学组成部分能够相互作用。核心将负责确保调查人员作为一个有凝聚力和互动的小组发挥作用，为项目和生物信息学核心之间的定期和频繁互动提供所需的规划和领导。共享网站将为项目提供综合服务，以实现最佳质量、效率和数据共享。此外，该核心将确保与加州大学洛杉矶分校和宾夕法尼亚大学现有的干细胞研究中心进行有效合作，以提供对基本资源和基础设施的最佳访问，并利用各自机构现有的高通量测序、微阵列和干细胞资源。该中心将通过试点项目的分配，招募更多的研究人员来研究人类细胞的多能性和重新编程。行政核心还将提供集中的赠款管理，包括协调调查人员之间的互动。核心使用，向NIGMS报告，预算监督和管理，并确保遵守所有管理IBC和ESCRO的法规和政策。一个由干细胞生物学和表观遗传学的内部和外部专家组成的科学咨询委员会将促进项目的互动和监督。

Description The Administrative Core will support all of the Projects and the Bioinformatics Core of this Program. Kathrin Plath, Program PI, will be the Leader of the Administrative Core, with support from Drs. Smale and Zaret as Co-Investigators. This Core will enable all of the scientific components of the Program to interact by providing the structure and financial support for regular planning, sharing, and evaluation of the research. The Core will be responsible for ensuring that the investigators act as a cohesive and interactive group by providing the planning and leadership required for regular and frequent interactions among the Projects and the Bioinformatics Core. A shared Web site will support the projects with integrated services for optimal quality, efficiency, and data-sharing. In addition, the core will ensure efficient collaborations with the existing stem cell research centers at UCLA and UPenn to provide optimal access to basic resources and infrastructure and leverage existing high-throughput sequencing, microarray, and stem cell resources at the respective institutions. The Core will recruit additional investigators to the study of human cell pluripotency and reprogramming through the distribution of pilot projects. The Administrative Core will also provide centralized grant administration, including coordinating interactions of the investigators. Core usage, reporting to the NIGMS, budget oversight and management, and ensuring compliance with all governing IBC and ESCRO regulations and policies. Program interactions and oversight will be facilitated by a Scientific Advisory Board composed of both internal and external experts in stem cell biology and epigenetics.