2023 Liquid Crystals Gordon Research Conference & Gordon Research Seminar

2023年液晶戈登研究会议

• 批准号: 10683604
• 负责人: Cecilia Leal
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683604
• 关键词: 2019-nCoV; Academia; Address; Alzheimer' s Disease; Applied Research; Area; Basic Science; Biological; Biology; Biosensing Techniques; Biosensor; Birth; Capsid; Caring; Cell membrane; Chemistry; Collaborations; Colloids; Color; Communities; Complement 2; Detection; Diagnosis; Disease; Elastomers; Engineering; Environment; Equity; Faculty; Female; Fostering; Future; Goals; Hour; Human body; Implant; Industry; International; Joints; Leadership; Life; Lipids; Liquid substance; Medical; Membrane Lipids; Membrane Microdomains; Mentors; Military Personnel; Minority Groups; Minority Participation; Mission; Muscle; National Institute of Biomedical Imaging and Bioengineering; Nature; New Hampshire; Nucleic Acids; Oral; Participant; Pharmacologic Substance; Phase; Phase Transition; Physics; Play; Polymers; Postdoctoral Fellow; Prevention; Proteins; Reporting; Research; Research Personnel; Robotics; Role; Science; Scientist; Students; Suspensions; Technology; Toxin; Underrepresented Minority; United States National Institutes of Health; Universities; Viral; Virus; Voice; Water; Woman; active lifestyle; career; elastomeric; empowerment; experimental study; flexibility; liquid crystal; materials science; meetings; pathogen; peer; posters; prevent; self assembly; sensor; social; symposium; theories; tool

Project Summary Significance, timeliness and rationale. NIBIB's mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the unique combination of flexibility and confining ability of cell membranes which is possible because lipids cooperatively aggregate into a lamellar LC phase in water. The phase separation underlying the lipid raft paradigm of plasma membrane organization bears all the hall- marks of inter-LC phase transitions, as does separation in suspensions of amyloidogenic protein fibrils in Alz- heimer's disease. Many viruses, e.g., SARS-CoV-2, are enveloped in a lipid membrane and they may employ LC order for packing their nucleic acid cargo. Non-biological LCs have turned out to be sensitive in detecting and reporting on the presence of pathogens and toxins, making them highly interesting for autonomous bio- /chemosensors. LC formation is thus an integral component of what keeps us healthy and causes disease, and they are emerging as a powerful tool for detecting disease agents. Although this connection is known since long, it has until now been researched only marginally, constituting an under-explored opportunity in addressing soci- etal needs. Today, the international LC research community is undergoing a rebirth, fully embracing these as- pects. Interdisciplinary crossovers where LC science meets biological, life and pharmaceutical sciences, and engineering and materials science, play a groundbreaking role in leveraging the opportunities. Additional impact on the core fields of the NIH-NIBIB mission comes from, e.g., the exploration of LC elastomers in soft actuators or implants in the human body. Objective. The chairs seek support for the Gordon Research Conference (GRC) and Seminar (GRS) on Liquid Crystals 2023:“ From Nature to Transformational Technology through Liquid Crys- tal Science”, Southern New Hampshire University, Manchester, NH, June 24–25 (GRS), June 25-June 30 (GRC), 2023. The joint meetings will bring together US and international researchers at the forefront of today's vibrant LC science, spanning its full breadth and connecting academia, industry and military labs, young and senior, and harnessing every opportunity to promote women and underrepresented minorities as speakers, discussing lead- ers and participants. Approach. 30 prominent speakers have confirmed our invitations to present unpublished cutting-edge research, covering, e.g., LCs in and from nature, LC-self-assembly in colloids and polymers, and in emerging applications. 52% of speakers are female and 37% are non-white. Academic speakers are comple- mented by 2 industry and 2 military research lab speakers. Additionally, 5 speaker slots will be given to excellent young scientists selected from submitted poster abstracts. To further strengthen the voice of young researchers, the GRC is preceded by the GRS, catering only to students and post-docs and providing mentoring and career advice, and during the GRC, young scientists will be given precedence in all scientific discussions.

项目摘要 重要性、及时性和理由。NIBIB的使命是通过工程改造理解 疾病及其预防、检测、诊断和治疗。没有液体生命就不可能存在 结晶（LC）顺序。最著名的例子是灵活性和限制能力的独特结合 这是可能的，因为脂质在水中协同聚集成层状LC相。 质膜组织的脂筏范例下的相分离承担了所有的霍尔- LC间相变的标记，如在Alz中淀粉样蛋白原纤维的悬浮液中的分离一样， 海默氏病许多病毒，例如，SARS-CoV-2被包裹在脂质膜中， 信用证订单包装他们的核酸货物。非生物LC已被证明在检测和 报告病原体和毒素的存在，使它们对自主生物非常感兴趣， /化学传感器。因此，LC形成是保持我们健康和引起疾病的组成部分， 它们正在成为检测病原体的有力工具。虽然这种联系早已为人所知， 到目前为止，对这一问题的研究很少，这是解决社会问题的一个未充分探讨的机会。 需要埃塔尔。今天，国际LC研究界正在经历重生，完全接受这些作为- pects.跨学科的交叉，LC科学满足生物，生命和制药科学，以及 工程和材料科学在利用这些机会方面发挥着开创性的作用。额外影响 关于NIH-NIBIB使命的核心领域，例如，LC弹性体在软驱动器中的应用 或者植入人体Objective.主席们寻求对戈登研究会议（GRC）的支持 2023年液晶研讨会（GRS）：“通过液晶从自然到转型技术- 谈话科学”，南新罕布什尔州大学，曼彻斯特，NH，6月24-25日（GRS），6月25- 6月30日（GRC）， 2023.联合会议将汇集美国和国际研究人员在当今充满活力的前沿， LC科学，跨越其全方位和连接学术界，工业和军事实验室，年轻和高级， 利用一切机会促进妇女和代表性不足的少数群体成为发言人，讨论铅， 参与者和参与者。Approach. 30位著名的演讲者已经确认了我们的邀请， 尖端研究，涵盖，例如，自然界中的LC，胶体和聚合物中的LC自组装，以及 在新兴的应用中。52%的发言者是女性，37%是非白人。学术发言人是复杂的- 由2名工业和2名军事研究实验室发言人主讲。此外，5个扬声器插槽将给予优秀的 从提交的海报摘要中选出的青年科学家。为进一步加强青年科研人员的话语权， GRC之前是GRS，仅面向学生和博士后，并提供指导和职业生涯 建议，并在GRC期间，年轻科学家将优先考虑所有科学讨论。