2023 Liquid Crystals Gordon Research Conference & Gordon Research Seminar

项目摘要 重要性、及时性和合理性。NIBIB的使命是通过工程技术转变对 疾病及其预防、检测、诊断和治疗。没有液体就不可能有生命 晶体(LC)顺序。最著名的例子是灵活性和限制能力的独特结合 这是可能的，因为脂类在水中协同聚集成片状LC相。 质膜组织的脂筏范例下的相分离承担了所有的大厅- 液晶间相变的标志，以及在阿尔茨海默氏液中淀粉样蛋白纤维悬浮液中的分离。 海默氏症。许多病毒，如SARS-CoV-2，被包裹在脂膜中，它们可能会利用 装运他们的核酸货物的信用证订单。事实证明，非生物液晶在检测和 报道病原体和毒素的存在，使它们对自主生物非常有趣- /化学传感器。因此，LC的形成是保持我们健康和导致疾病的不可或缺的组成部分，并且 它们正在成为检测疾病病原体的强大工具。尽管这种联系很早就知道了， 到目前为止，人们对它的研究还很少，这构成了一个尚未被探索的机会，可以解决社会问题。 其他方面的需求。今天，国际LC研究界正在经历一场重生，完全接受这些作为- 很有可能。LC科学与生物、生命和制药科学的跨学科交叉，以及 工程和材料科学在利用这些机会方面发挥着开创性的作用。其他影响 NIH-NIBIB任务的核心领域来自于软执行器中LC弹性体的探索 或植入人体内。目标。主席寻求对戈登研究会议(GRC)的支持 和关于液晶2023的研讨会(GRS)：“通过液晶从自然到变革的技术-- 《塔尔科学》，南新汉普郡大学，曼彻斯特，NH，6月24日至25日(GRS)，6月25日至6月30日(GRC)， 2023年。联合会议将把美国和国际研究人员聚集在当今充满活力的 LC科学，跨越其全部广度，连接学术界、工业和军事实验室，无论年轻的还是年长的，以及 利用每一个机会促进妇女和代表不足的少数群体作为发言者，讨论领导- 参赛者和参赛者。接近。30位著名演讲者已经确认了我们的邀请，将发表未发表的演讲 前沿研究，包括自然界和自然界中的液晶，胶体和聚合物中的液晶自组装，以及 在新兴应用中。52%的演讲者是女性，37%的人是非白人。学术演讲者很多- 由2名工业和2名军事研究实验室演讲者组成。此外，优秀奖还将获得5个演讲者席位 青年科学家从提交的海报摘要中挑选出来。为了进一步增强年轻研究人员的发言权， GRC之前是GRS，只为学生和博士后提供服务，并提供指导和职业 建议，在GRC期间，年轻科学家将在所有科学讨论中得到优先考虑。

Project Summary Significance, timeliness and rationale. NIBIB's mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the unique combination of flexibility and confining ability of cell membranes which is possible because lipids cooperatively aggregate into a lamellar LC phase in water. The phase separation underlying the lipid raft paradigm of plasma membrane organization bears all the hall- marks of inter-LC phase transitions, as does separation in suspensions of amyloidogenic protein fibrils in Alz- heimer's disease. Many viruses, e.g., SARS-CoV-2, are enveloped in a lipid membrane and they may employ LC order for packing their nucleic acid cargo. Non-biological LCs have turned out to be sensitive in detecting and reporting on the presence of pathogens and toxins, making them highly interesting for autonomous bio- /chemosensors. LC formation is thus an integral component of what keeps us healthy and causes disease, and they are emerging as a powerful tool for detecting disease agents. Although this connection is known since long, it has until now been researched only marginally, constituting an under-explored opportunity in addressing soci- etal needs. Today, the international LC research community is undergoing a rebirth, fully embracing these as- pects. Interdisciplinary crossovers where LC science meets biological, life and pharmaceutical sciences, and engineering and materials science, play a groundbreaking role in leveraging the opportunities. Additional impact on the core fields of the NIH-NIBIB mission comes from, e.g., the exploration of LC elastomers in soft actuators or implants in the human body. Objective. The chairs seek support for the Gordon Research Conference (GRC) and Seminar (GRS) on Liquid Crystals 2023:“ From Nature to Transformational Technology through Liquid Crys- tal Science”, Southern New Hampshire University, Manchester, NH, June 24–25 (GRS), June 25-June 30 (GRC), 2023. The joint meetings will bring together US and international researchers at the forefront of today's vibrant LC science, spanning its full breadth and connecting academia, industry and military labs, young and senior, and harnessing every opportunity to promote women and underrepresented minorities as speakers, discussing lead- ers and participants. Approach. 30 prominent speakers have confirmed our invitations to present unpublished cutting-edge research, covering, e.g., LCs in and from nature, LC-self-assembly in colloids and polymers, and in emerging applications. 52% of speakers are female and 37% are non-white. Academic speakers are comple- mented by 2 industry and 2 military research lab speakers. Additionally, 5 speaker slots will be given to excellent young scientists selected from submitted poster abstracts. To further strengthen the voice of young researchers, the GRC is preceded by the GRS, catering only to students and post-docs and providing mentoring and career advice, and during the GRC, young scientists will be given precedence in all scientific discussions.