Mechanisms and Barriers in Nanomedicine-2023

近年来，在合成和表征方面取得了显著的进展， 用于成像和治疗癌症的工程纳米粒子，导致几个有前途的 临床试验中的候选人。然而，纳米药物递送领域需要更好地了解 生物和免疫屏障，癌症病理学和免疫学，以及适当和相关的 疾病的模型。在实地，越来越多的人认为，需要重新审视基本问题， 更好地了解综合生物学，病理生理学和免疫学过程， 有效地转化为纳米医学设计和性能。我们提议组织一次会议- 2023年5月，在科罗拉多的戈尔登举办了“纳米医学的机制和障碍”研讨会。程序 将集中在以下几个方面：a）颗粒界面的相互作用; B）免疫识别 c）模型的相关性; d）体内屏障; d）新靶点; d） 监管/行业障碍的翻译。主要专家将讨论系统的综合作用 调节纳米药物滞留免疫学、蛋白质冠、肿瘤和血管细胞生物学 和肿瘤的功能。我们努力实现以下目标：a）提供一个教育，但 关键的，论坛到综合生化和生物屏障控制纳米粒子的交付和 B）介绍关于减轻和消除贫穷战略的最新情况和可能的模式转变， 这些问题; c）通过在高级教师中进行公开的，不受限制的，非专有的讨论， 年轻的研究人员和研究生，我们希望引发新的想法和概念，将移动 该字段向前。会议-讲习班的主要创新之处在于提供了一个公开论坛， 讨论药物输送的问题，并集中在生物学，免疫学和翻译 纳米技术方面。R13补助金将用于帮助学生参加会议 和博士后，包括代表性不足，种族和民族群体，残疾人， 来自弱势背景的个人和妇女。

In the recent years, remarkable progress has been made in the synthesis and characterization of engineered nanoparticles for imaging and treatment of cancers, resulting in several promising candidates in clinical trials. However, the nano drug delivery field needs a better understanding of biological and immunological barriers, cancer pathology and immunology, and appropriate and relevant models of disease. There is a growing sentiment in the field that there is need to revisit the basics and to better understand the integrated biological, pathophysiological and immunological processes for effective translation to nanomedicine design and performance. We propose to organize a conference- workshop “Mechanisms and Barriers in Nanomedicine” in Golden, Colorado in May 2023. The program will be focused on the following aspects: a) interactions at the particle interface; b) immune recognition and toxicity of nanomaterials; c) relevance of models; d) in vivo barriers; d) new targets; d) regulatory/industrial hurdles to translation. Leading experts will discuss the integrated roles of systems immunology, protein corona, and tumor and vascular cell biology that modulate nanomedicine retention and functionality in tumors. We strive to achieve the following goals: a) to provide an educational, yet critical, forum into integrated biochemical and biological barriers controlling nanoparticle delivery and their functionality; b) to present an update and potential paradigm shift on the strategies to mitigating these problems; c) by conducting open, unrestricted, non-proprietary discussion among senior faculty, young investigators and graduate students, we hope to trigger new ideas and concepts that will move the field forward. The main innovation of the conference-workshop is in providing an open forum for discussing problems with drug delivery and in the focus on biological, immunological and translational aspects of nanotechnology. The R13 grant will be used to help with conference attendance for students and postdocs, including underrepresented, racial and ethnic groups, individuals with disabilities, individuals from disadvantaged backgrounds, and women.