Addressing Colorectal Cancer-Related Distress: Developing and Evaluating a Couple-Based Mindfulness Intervention
解决结直肠癌相关的困扰:制定和评估基于夫妻的正念干预措施
基本信息
- 批准号:10683394
- 负责人:
- 金额:$ 16.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-12 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAreaAttentionAwarenessBehavioralBeliefBody ImageCancer PatientCancer SurvivorCancer SurvivorshipChronicClinicalColorectal CancerCommunicationCompassionContinuance of lifeCouplesDataDevelopmentDiagnosisDistressEducationEducational process of instructingEmotionsEvaluationExcisionFatigueFecal IncontinenceFecesFutureGoalsIndividualInterventionInterviewIntestinesLengthLifeLightLoveMalignant NeoplasmsMeasuresMediatorNatureOperative Surgical ProceduresOstomyOutcomeParticipantPatientsPerceptionPersonsProtocols documentationQuality of lifeRandomizedRandomized, Controlled TrialsReportingResearchResearch PersonnelResearch Project GrantsSamplingScienceSexualityShameStructureSurveysTimeTrainingTreatment Efficacyactive methodcancer carecare giving burdenclinical careclinically significantcognitive interviewcolon cancer patientscopingdesigneffective interventionemotional distressend of lifeevidence baseexpectationexperiencegastrointestinal symptomimprovedinnovationintervention deliveryintervention effectintervention refinementintimate behaviormembermetastatic colorectalmindfulnessmindfulness interventionphysical symptompilot trialpost interventionpreferenceprimary outcomepsychologicpsychosocialrandomized trialresearch studyside effectskillsskills trainingtherapy designtooltrendvideoconference
项目摘要
PROJECT SUMMARY/ABSTRACT
A diagnosis of metastatic colorectal cancer (mCRC) and its treatment is life-altering; up to 60% of mCRC patients
and a similar percentage of their intimate partners report clinically significant levels of distress.1-5 Effects of
mCRC often lead to unique challenges on both an individual and relationship level,6-14 and an intervention
designed to address these concerns and reduce distress in couples facing mCRC is critically needed.6-8,10-12,28,30
A mindfulness-based intervention (MBI) could fill this gap, given strong evidence for reducing distress in cancer
patients32-34 and partners35 and in improving relationship outcomes.36-38 However, existing MBIs are poorly suited
for couples facing mCRC due to several inadequacies in their content and format. Given significant changes that
would be needed to modify an existing MBI, a new couple-based MBI designed to meet the unique needs of
mCRC couples is warranted. Therefore, the overall objective of the proposed research project is to develop,
refine, and evaluate a four-session, couple-based mindfulness intervention (“MIND-Together”: Mindfully
Navigating Distress Together) delivered via video-conference and designed to promote mindful coping and
reduce distress for mCRC patients and their partners. First, we will generate data on the needs and preferences
of 12 couples facing mCRC (N=24 patients and partners) and 12 clinicians treating mCRC through qualitative
interviews, which will include queries about intervention content (e.g., scope) and structure (e.g., format). Then
we will develop drafts of the intervention protocol, which will be refined and finalized through cognitive interviews
with 6 mCRC couples (N=12 patients and partners) and expert review. Second, we will assess the feasibility,
acceptability, and preliminary effects of the intervention through a pilot randomized controlled trial among 45
mCRC couples (N=90 patients and partners), assigned 2:1 to either MIND-Together (n=30 couples) or an
attention-controlled condition (n=15 couples). In an exploratory aim, we will use exit interviews to explore
couples’ experiences of MIND-Together in order to further optimize the intervention content and delivery, and
identify potential mechanisms to assess in future trials. Upon study completion, we will have established whether
the intervention is feasible, acceptable, and preliminarily efficacious in reducing distress in a sample of couples
facing mCRC. Future research will be to evaluate the intervention efficacy and assess mediators in a larger
randomized trial. In addition to the research study, formal training in three content areas will support the PI’s goal
of becoming an independent investigator with expertise in the development, evaluation, and delivery of
interventions among individuals affected by cancer. Training areas include: (1) cancer survivorship issues among
colorectal cancer patients, (2) couple-based approaches for improving psychosocial outcomes in cancer
survivors, and (3) developing and evaluating psychosocial interventions. Overall, the proposed research has the
potential to help address the critical psychosocial needs of couples facing mCRC and to advance the science of
mindfulness and couple-based approaches in cancer care.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lauren A. Zimmaro其他文献
Body compassion in the context of cancer: A novel exploration among colorectal cancer survivors
- DOI:
10.1007/s00520-024-08996-0 - 发表时间:
2024-11-28 - 期刊:
- 影响因子:3.000
- 作者:
Lauren A. Zimmaro;Aimee J. Christie;Jennifer K. Altman;Andrew Nicklawsky;James W. Carson;Christopher Lieu;Carolyn Fang;Jennifer B. Reese - 通讯作者:
Jennifer B. Reese
Lauren A. Zimmaro的其他文献
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{{ truncateString('Lauren A. Zimmaro', 18)}}的其他基金
Addressing Colorectal Cancer-Related Distress: Developing and Evaluating a Couple-Based Mindfulness Intervention
解决结直肠癌相关的困扰:制定和评估基于夫妻的正念干预措施
- 批准号:
10740260 - 财政年份:2022
- 资助金额:
$ 16.45万 - 项目类别:
Addressing Colorectal Cancer-Related Distress: Developing and Evaluating a Couple-Based Mindfulness Intervention
解决结直肠癌相关的困扰:制定和评估基于夫妻的正念干预措施
- 批准号:
10525291 - 财政年份:2022
- 资助金额:
$ 16.45万 - 项目类别:
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