Biospecimen Core

生物样本核心（BIO）：项目总结 衰老的特征是分子和细胞损伤的积累，导致细胞凋亡减少。 功能.这种损害的程度和时间进展是一个异质过程， 环境和遗传因素的复杂相互作用，可以改善和/或加剧正常的 衰老哥伦比亚大学衰老组织图谱（CUSTMAP）的总体目标 中心的重点是关键器官系统的脆弱性与年龄相关的退行性过程;中央 神经系统和皮肤。选择这些系统是因为它们代表了具有突出 适应/再生能力和异质细胞类型，这将使我们能够研究局部影响， 衰老对基因表达特征的影响，以及这如何影响细胞组成和增加 易受与年龄有关的损伤和疾病的影响。CUSTMAP中心的核心是一致的 获得已同意的表型良好、高质量、无疾病的人体组织 广泛的数据共享。我们通过我们一流的临床表型分析和 生物库资源通过我们的生物样本核心（BIO），我们将编译一个最大的 具有跨越寿命的组织的多国队列，具有可比和可量化的临床 相关性，通过继续我们的前瞻性收集的高质量的情况下，在两个 爱丁堡大学和哥伦比亚大学欧文医学中心。我们的BIO将汇集一个 领导团队来自不同的临床和研究背景，具有互补的既定专业知识 临床表型分析和组织生物库。这个核心的目的不仅是协同我们的生物 分析核心是实现拟议目标的成果，但也要建立一个国际框架 用于表型组织库的标准化方法。我们希望通过建立这一框架， 这将有助于在这一领域开展更高质量的生前和死后与人类有关的研究。

BIOSPECIMEN CORE (BIO): PROJECT SUMMARY Aging is characterized by the accumulation of molecular and cellular damage resulting in decreasing cellular functionality. The extent and temporal progression of this damage is a heterogeneous process due to the complex interactions of environmental and genetic factors that can ameliorate and/or exacerbate normal aging. The overarching goal of the Columbia University Senescence Tissue Mapping (CUSTMAP) Center is to focus on key organ systems with vulnerability to age-related degenerative processes; the central nervous system and skin. These systems were selected as they represent organs with prominent adaptive/regenerative ability and heterogeneous cell types that will allow us to investigate the local effects of aging on gene expression signatures and how this impacts upon cellular composition and increase susceptibility to age-related damage and diseases. At the core of the CUSTMAP Center is consistent accessibility to well-phenotyped, high-quality, non-diseased human tissue that has been consented for broad data sharing. We are ideally positioned for this effort through our premier clinical phenotyping and biobanking resources. Through our Biospecimen Core (BIO), we will compile one of the largest multinational cohorts with tissues spanning the lifespan, with comparable and quantifiable clinical correlates, by continuing our prospective collection of comparably phenotyped high quality cases at both the University of Edinburgh and Columbia University Irving Medical Center. Our BIO will bring together a leadership team from diverse clinical and research backgrounds with complementary established expertise in clinical phenotyping and tissue biobanking. The aim of this core is not only to synergize with our Biological Analysis Core to deliver the outcomes of the proposed aims, but also to establish an international framework for a standardized approach to phenotypic tissue banking. Our hope is that by establishing this framework it will enable a higher quality of ante- and post-mortem, human-relevant research to be carried out in this field.