AIDS and Aging Research Platform (AARP)

艾滋病和老龄化研究平台 (AARP)

• 批准号: 10683071
• 负责人: STEVEN N. AUSTAD
• 金额: $ 76.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683071
• 关键词: Acceleration; Acquired Immunodeficiency Syndrome; Address; Age; Age-associated memory impairment; Aging; American; Area; Behavioral Research; Biology of Aging; Brain; Capsicum; Cardiovascular Diseases; Caring; Cessation of life; Chronic Disease; Clinic; Clinical; Data; Development; Diabetes Mellitus; Education; Elderly; Equipment and supply inventories; Future; Geriatrics; Gerontology; Geroscience; Goals; HIV; Hearing; Hospitalization; Impaired cognition; Individual; Infrastructure; Intervention; Investigation; Kidney Diseases; Link; Liver diseases; Longevity; Malignant Neoplasms; Mentors; Metabolic syndrome; Modeling; Molecular; Neurocognition; Outcomes Research; Persons; Phenotype; Physical Function; Pilot Projects; Prevention; R24; Research; Research Personnel; Resources; Science; Sensory; Shock; Site; Stroke; Syndrome; System; Testing; Time; Training; United States National Institutes of Health; Vision; Work; antiretroviral therapy; clinical care; clinical phenotype; clinical research site; cognitive testing; comorbidity; data integration; disability; exercise program; experience; falls; frailty; functional decline; functional disability; healthspan; human old age (65+); improved; insight; interdisciplinary collaboration; meetings; middle age; mortality; multiple chronic conditions; programs; response; small molecule; social; success; tool

ABSTRACT Effective antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality resulting in many surviving into middle and old age. Despite this success, PLWH experience high rates of comorbidities, multimorbidity (>1 major chronic illness), and functional decline at ages 10-15 years younger than uninfected controls. Geriatric syndromes, such as frailty and falls, are becoming more prevalent in PLWH. Thus, there is an urgent need to focus on the healthspan of PLWH rather than just mortality. Healthspan, in contrast to lifespan, is defined as the time someone is healthy not just alive. The Claude D. Pepper Older American Independence Centers (OAlCs) were established to help define aging phenotypes and advance research into the causes, prevention and treatment of functional decline with age. OAlCs have developed and validated functional assessments in aging, but lack depth and breadth of HIV expertise. In contrast, Centers for AIDS Research (CFARs) have unparalleled expertise in HIV-related basic, clinical and social/behavioral research, but lack robust resources and expertise in aging biology, geriatric clinical phenotypes and functional assessments. Our R24 project, “Developing Research At The Interface Of HIV And Aging” was in response to PA-12-064 "Network and Infrastructure Support for Development of Interdisciplinary Aging Research." Through this R24 we successfully linked CFARs and OAICs to support pilot projects in high-priority focus areas and mentor researchers at the interface of HIV and Aging. Our vision for this proposal is to build on this success deepening the ongoing linkage of CFARs and OAICs and expanding the network to include Nathan Shock Centers of Excellence in the Basic Biology of Aging (NSCs) and the McKnight Brain Institutes (MBIs). By bringing together OAICs expertise on functional decline in aging, with NSC expertise in aging biology and the mechanisms underlying function decline, with MBI expertise on age-related cognitive decline, and CFAR expertise on HIV, we create an integrated approach to advancing and accelerating investigation at the interface of HIV and aging via the following Aims: Aim 1. Provide specific training models and a brief inventory of tools to efficiently collect data to improve HIV clinical care and outcomes research. Aim 2. Using a geroscience approach, provide a platform for pilot studies to determine the links between molecular hallmarks of aging with functional decline, and the development of common comorbidities among aging PLWH. Aim 3. Develop infrastructure for evaluating interventional approaches and their application to HIV care. Aim 4. Provide educational support, implementation advice and mentoring for emerging investigators to establish/advance research programs in HIV and aging. These synergistic aims leverage and expand the infrastructure and close ties built in the R24 of HIV expertise from CFARs with the gerontology and functional assessment expertise within the OAlCs and expand them with inclusion of NSCs and MBIs to enhance and accelerate investigation at the interface of HIV and aging.

摘要 针对艾滋病毒携带者的有效抗逆转录病毒疗法(ART)显著降低了死亡率。 导致许多人活到中老年。尽管取得了这一成功，但PLWH经历了高比率的 10-15岁时出现合并症、多病(1种主要慢性病)和功能衰退 而不是未感染的对照组。老年综合征，如虚弱和跌倒，在PLWH中变得更加普遍。 因此，迫切需要关注PLWH的健康范围，而不仅仅是死亡率。健康范围，英寸 相对于寿命，定义为一个人健康的时间，而不仅仅是活着的时间。年长的克劳德·D·佩珀 美国独立中心(OAlCs)的成立是为了帮助定义衰老表型和促进 探讨增龄性功能减退的原因及防治。OAlc已经开发出了 在老龄化方面经过验证的功能评估，但缺乏艾滋病毒专业知识的深度和广度。与之形成对比的是， 艾滋病研究(CFAR)在艾滋病毒相关的基础、临床和社会/行为方面拥有无与伦比的专业知识 研究，但在衰老生物学、老年临床表型和功能方面缺乏强有力的资源和专业知识 评估。我们的R24项目“在艾滋病毒与老龄化的界面上开展研究”是对 PA-12-064“跨学科老龄化研究发展的网络和基础设施支持”。穿过 在R24中，我们成功地将CFAR和OAIC联系起来，以支持高优先级重点领域的试点项目 在艾滋病毒和老龄化的界面上指导研究人员。我们对这项提议的愿景是在这一成功的基础上再接再厉 深化CFARs和OAICs之间的持续联系，并将网络扩大到包括Nathan Shock 老龄化基础生物学卓越中心(NSCs)和麦克奈特脑研究所(MBIS)。通过 将OAICs在衰老功能衰退方面的专业知识与NSC在衰老生物学和 功能下降的潜在机制，具有MBI在年龄相关认知下降方面的专业知识，以及CFAR 作为艾滋病毒方面的专业知识，我们创建了一种综合方法来推进和加快 通过以下目标实现艾滋病毒与老龄化的对接： 目标1.提供具体的培训模式和简要的工具清单，以便有效地收集数据以改进艾滋病毒 临床护理和结果研究。目标2.使用老年科学方法，为先导研究提供平台 为了确定衰老的分子特征与功能衰退之间的联系，以及糖尿病的发展 老年PLWH常见的并存疾病。目标3.开发评估干预措施的基础设施 艾滋病毒护理的方法及其应用。目标4.提供教育支持、实施建议和 指导新出现的研究人员建立/推进艾滋病毒和老龄化研究计划。 这些协同作用的目标是利用和扩大艾滋病毒专门知识R24中建立的基础设施和密切联系 来自具有OALC内老年学和功能评估专业知识的CFAR，并通过以下方式扩展它们 纳入NSCs和MBIS，以加强和加快艾滋病毒与老龄化交界处的调查。

项目成果

Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.

在一项纵向临床队列研究中评估艾滋病毒感染者虚弱状态的病戒假说和减少饮酒。

• DOI: 10.1097/jnc.0000000000000445
• 发表时间: 2024
• 期刊: The Journal of the Association of Nurses in AIDS Care : JANAC
• 作者: Ruderman,StephanieA;Drumright,LydiaN;Delaney,JosephAC;Webel,AllisonR;Fitzpatrick,AnnetteL;Whitney,BridgetM;Nance,RobinM;Hahn,AndrewW;Ma,Jimmy;Mixson,L.Sarah;Eltonsy,Sherif;Willig,AmandaL;Mayer,KennethH;Napravnik,Sonia
• 通讯作者: Napravnik,Sonia

Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States.

• DOI: 10.1097/jnc.0000000000000389
• 发表时间: 2023-03-01
• 期刊: JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
• 影响因子: 2
• 作者: Ruderman, Stephanie A.;Webel, Allison R.;Willig, Amanda L.;Drumright, Lydia N.;Fitzpatrick, Annette L.;Odden, Michelle C.;Cleveland, John D.;Burkholder, Greer;Davey, Christine H.;Fleming, Julia;Buford, Thomas W.;Jones, Raymond;Nance, Robin M.;Whitney, Bridget M.;Mixson, L. Sarah;Hahn, Andrew W.;Mayer, Kenneth H.;Greene, Meredith;Saag, Michael S.;Kamen, Charles;Pandya, Chintan;Lober, William B.;Kitahata, Mari M.;Crane, Paul K.;Crane, Heidi M.;Delaney, Joseph A. C.
• 通讯作者: Delaney, Joseph A. C.

Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.

吸烟和吸烟年数与艾滋病毒感染者的虚弱有关。

• DOI: 10.1097/qai.0000000000003242
• 发表时间: 2023
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Ruderman,StephanieA;Odden,MichelleC;Webel,AllisonR;Fitzpatrick,AnnetteL;Crane,PaulK;Nance,RobinM;Drumright,LydiaN;Whitney,BridgetM;Mixson,LyndseySarah;Ma,Jimmy;Willig,AmandaL;Haidar,Lara;Eltonsy,Sherif;Mayer,KennethH