AIDS and Aging Research Platform (AARP)
艾滋病和老龄化研究平台 (AARP)
基本信息
- 批准号:10683071
- 负责人:
- 金额:$ 76.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcquired Immunodeficiency SyndromeAddressAgeAge-associated memory impairmentAgingAmericanAreaBehavioral ResearchBiology of AgingBrainCapsicumCardiovascular DiseasesCaringCessation of lifeChronic DiseaseClinicClinicalDataDevelopmentDiabetes MellitusEducationElderlyEquipment and supply inventoriesFutureGeriatricsGerontologyGeroscienceGoalsHIVHearingHospitalizationImpaired cognitionIndividualInfrastructureInterventionInvestigationKidney DiseasesLinkLiver diseasesLongevityMalignant NeoplasmsMentorsMetabolic syndromeModelingMolecularNeurocognitionOutcomes ResearchPersonsPhenotypePhysical FunctionPilot ProjectsPreventionR24ResearchResearch PersonnelResourcesScienceSensoryShockSiteStrokeSyndromeSystemTestingTimeTrainingUnited States National Institutes of HealthVisionWorkantiretroviral therapyclinical careclinical phenotypeclinical research sitecognitive testingcomorbiditydata integrationdisabilityexercise programexperiencefallsfrailtyfunctional declinefunctional disabilityhealthspanhuman old age (65+)improvedinsightinterdisciplinary collaborationmeetingsmiddle agemortalitymultiple chronic conditionsprogramsresponsesmall moleculesocialsuccesstool
项目摘要
ABSTRACT
Effective antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality
resulting in many surviving into middle and old age. Despite this success, PLWH experience high rates of
comorbidities, multimorbidity (>1 major chronic illness), and functional decline at ages 10-15 years younger
than uninfected controls. Geriatric syndromes, such as frailty and falls, are becoming more prevalent in PLWH.
Thus, there is an urgent need to focus on the healthspan of PLWH rather than just mortality. Healthspan, in
contrast to lifespan, is defined as the time someone is healthy not just alive. The Claude D. Pepper Older
American Independence Centers (OAlCs) were established to help define aging phenotypes and advance
research into the causes, prevention and treatment of functional decline with age. OAlCs have developed and
validated functional assessments in aging, but lack depth and breadth of HIV expertise. In contrast, Centers for
AIDS Research (CFARs) have unparalleled expertise in HIV-related basic, clinical and social/behavioral
research, but lack robust resources and expertise in aging biology, geriatric clinical phenotypes and functional
assessments. Our R24 project, “Developing Research At The Interface Of HIV And Aging” was in response to
PA-12-064 "Network and Infrastructure Support for Development of Interdisciplinary Aging Research." Through
this R24 we successfully linked CFARs and OAICs to support pilot projects in high-priority focus areas and
mentor researchers at the interface of HIV and Aging. Our vision for this proposal is to build on this success
deepening the ongoing linkage of CFARs and OAICs and expanding the network to include Nathan Shock
Centers of Excellence in the Basic Biology of Aging (NSCs) and the McKnight Brain Institutes (MBIs). By
bringing together OAICs expertise on functional decline in aging, with NSC expertise in aging biology and the
mechanisms underlying function decline, with MBI expertise on age-related cognitive decline, and CFAR
expertise on HIV, we create an integrated approach to advancing and accelerating investigation at the
interface of HIV and aging via the following Aims:
Aim 1. Provide specific training models and a brief inventory of tools to efficiently collect data to improve HIV
clinical care and outcomes research. Aim 2. Using a geroscience approach, provide a platform for pilot studies
to determine the links between molecular hallmarks of aging with functional decline, and the development of
common comorbidities among aging PLWH. Aim 3. Develop infrastructure for evaluating interventional
approaches and their application to HIV care. Aim 4. Provide educational support, implementation advice and
mentoring for emerging investigators to establish/advance research programs in HIV and aging.
These synergistic aims leverage and expand the infrastructure and close ties built in the R24 of HIV expertise
from CFARs with the gerontology and functional assessment expertise within the OAlCs and expand them with
inclusion of NSCs and MBIs to enhance and accelerate investigation at the interface of HIV and aging.
摘要
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.
在一项纵向临床队列研究中评估艾滋病毒感染者虚弱状态的病戒假说和减少饮酒。
- DOI:10.1097/jnc.0000000000000445
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Ruderman,StephanieA;Drumright,LydiaN;Delaney,JosephAC;Webel,AllisonR;Fitzpatrick,AnnetteL;Whitney,BridgetM;Nance,RobinM;Hahn,AndrewW;Ma,Jimmy;Mixson,L.Sarah;Eltonsy,Sherif;Willig,AmandaL;Mayer,KennethH;Napravnik,Sonia
- 通讯作者:Napravnik,Sonia
Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States.
- DOI:10.1097/jnc.0000000000000389
- 发表时间:2023-03-01
- 期刊:
- 影响因子:2
- 作者:Ruderman, Stephanie A.;Webel, Allison R.;Willig, Amanda L.;Drumright, Lydia N.;Fitzpatrick, Annette L.;Odden, Michelle C.;Cleveland, John D.;Burkholder, Greer;Davey, Christine H.;Fleming, Julia;Buford, Thomas W.;Jones, Raymond;Nance, Robin M.;Whitney, Bridget M.;Mixson, L. Sarah;Hahn, Andrew W.;Mayer, Kenneth H.;Greene, Meredith;Saag, Michael S.;Kamen, Charles;Pandya, Chintan;Lober, William B.;Kitahata, Mari M.;Crane, Paul K.;Crane, Heidi M.;Delaney, Joseph A. C.
- 通讯作者:Delaney, Joseph A. C.
Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.
吸烟和吸烟年数与艾滋病毒感染者的虚弱有关。
- DOI:10.1097/qai.0000000000003242
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Ruderman,StephanieA;Odden,MichelleC;Webel,AllisonR;Fitzpatrick,AnnetteL;Crane,PaulK;Nance,RobinM;Drumright,LydiaN;Whitney,BridgetM;Mixson,LyndseySarah;Ma,Jimmy;Willig,AmandaL;Haidar,Lara;Eltonsy,Sherif;Mayer,KennethH;
- 通讯作者:
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{{ truncateString('STEVEN N. AUSTAD', 18)}}的其他基金
A New Translational Rat Model for Evaluating Anti-Aging Interventions
用于评估抗衰老干预措施的新转化大鼠模型
- 批准号:
10665539 - 财政年份:2022
- 资助金额:
$ 76.99万 - 项目类别:
A New Translational Rat Model for Evaluating Anti-Aging Interventions
用于评估抗衰老干预措施的新转化大鼠模型
- 批准号:
10369517 - 财政年份:2022
- 资助金额:
$ 76.99万 - 项目类别:
A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and Longevity
研究健康和长寿性别差异的四核心基因型 (FCG) 方法
- 批准号:
9504206 - 财政年份:2018
- 资助金额:
$ 76.99万 - 项目类别:
A sex difference approach to evaluating resilience as a predictor of healthspan in mice
评估弹性作为小鼠健康寿命预测因子的性别差异方法
- 批准号:
10166754 - 财政年份:2017
- 资助金额:
$ 76.99万 - 项目类别:
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