AIDS and Aging Research Platform (AARP)
艾滋病和老龄化研究平台 (AARP)
基本信息
- 批准号:10683071
- 负责人:
- 金额:$ 76.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcquired Immunodeficiency SyndromeAddressAgeAge-associated memory impairmentAgingAmericanAreaBehavioral ResearchBiology of AgingBrainCapsicumCardiovascular DiseasesCaringCessation of lifeChronic DiseaseClinicClinicalDataDevelopmentDiabetes MellitusEducationElderlyEquipment and supply inventoriesFutureGeriatricsGerontologyGeroscienceGoalsHIVHearingHospitalizationImpaired cognitionIndividualInfrastructureInterventionInvestigationKidney DiseasesLinkLiver diseasesLongevityMalignant NeoplasmsMentorsMetabolic syndromeModelingMolecularNeurocognitionOutcomes ResearchPersonsPhenotypePhysical FunctionPilot ProjectsPreventionR24ResearchResearch PersonnelResourcesScienceSensoryShockSiteStrokeSyndromeSystemTestingTimeTrainingUnited States National Institutes of HealthVisionWorkantiretroviral therapyclinical careclinical phenotypeclinical research sitecognitive testingcomorbiditydata integrationdisabilityexercise programexperiencefallsfrailtyfunctional declinefunctional disabilityhealthspanhuman old age (65+)improvedinsightinterdisciplinary collaborationmeetingsmiddle agemortalitymultiple chronic conditionsprogramsresponsesmall moleculesocialsuccesstool
项目摘要
ABSTRACT
Effective antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality
resulting in many surviving into middle and old age. Despite this success, PLWH experience high rates of
comorbidities, multimorbidity (>1 major chronic illness), and functional decline at ages 10-15 years younger
than uninfected controls. Geriatric syndromes, such as frailty and falls, are becoming more prevalent in PLWH.
Thus, there is an urgent need to focus on the healthspan of PLWH rather than just mortality. Healthspan, in
contrast to lifespan, is defined as the time someone is healthy not just alive. The Claude D. Pepper Older
American Independence Centers (OAlCs) were established to help define aging phenotypes and advance
research into the causes, prevention and treatment of functional decline with age. OAlCs have developed and
validated functional assessments in aging, but lack depth and breadth of HIV expertise. In contrast, Centers for
AIDS Research (CFARs) have unparalleled expertise in HIV-related basic, clinical and social/behavioral
research, but lack robust resources and expertise in aging biology, geriatric clinical phenotypes and functional
assessments. Our R24 project, “Developing Research At The Interface Of HIV And Aging” was in response to
PA-12-064 "Network and Infrastructure Support for Development of Interdisciplinary Aging Research." Through
this R24 we successfully linked CFARs and OAICs to support pilot projects in high-priority focus areas and
mentor researchers at the interface of HIV and Aging. Our vision for this proposal is to build on this success
deepening the ongoing linkage of CFARs and OAICs and expanding the network to include Nathan Shock
Centers of Excellence in the Basic Biology of Aging (NSCs) and the McKnight Brain Institutes (MBIs). By
bringing together OAICs expertise on functional decline in aging, with NSC expertise in aging biology and the
mechanisms underlying function decline, with MBI expertise on age-related cognitive decline, and CFAR
expertise on HIV, we create an integrated approach to advancing and accelerating investigation at the
interface of HIV and aging via the following Aims:
Aim 1. Provide specific training models and a brief inventory of tools to efficiently collect data to improve HIV
clinical care and outcomes research. Aim 2. Using a geroscience approach, provide a platform for pilot studies
to determine the links between molecular hallmarks of aging with functional decline, and the development of
common comorbidities among aging PLWH. Aim 3. Develop infrastructure for evaluating interventional
approaches and their application to HIV care. Aim 4. Provide educational support, implementation advice and
mentoring for emerging investigators to establish/advance research programs in HIV and aging.
These synergistic aims leverage and expand the infrastructure and close ties built in the R24 of HIV expertise
from CFARs with the gerontology and functional assessment expertise within the OAlCs and expand them with
inclusion of NSCs and MBIs to enhance and accelerate investigation at the interface of HIV and aging.
摘要
针对艾滋病毒携带者的有效抗逆转录病毒疗法(ART)显著降低了死亡率。
导致许多人活到中老年。尽管取得了这一成功,但PLWH经历了高比率的
10-15岁时出现合并症、多病(1种主要慢性病)和功能衰退
而不是未感染的对照组。老年综合征,如虚弱和跌倒,在PLWH中变得更加普遍。
因此,迫切需要关注PLWH的健康范围,而不仅仅是死亡率。健康范围,英寸
相对于寿命,定义为一个人健康的时间,而不仅仅是活着的时间。年长的克劳德·D·佩珀
美国独立中心(OAlCs)的成立是为了帮助定义衰老表型和促进
探讨增龄性功能减退的原因及防治。OAlc已经开发出了
在老龄化方面经过验证的功能评估,但缺乏艾滋病毒专业知识的深度和广度。与之形成对比的是,
艾滋病研究(CFAR)在艾滋病毒相关的基础、临床和社会/行为方面拥有无与伦比的专业知识
研究,但在衰老生物学、老年临床表型和功能方面缺乏强有力的资源和专业知识
评估。我们的R24项目“在艾滋病毒与老龄化的界面上开展研究”是对
PA-12-064“跨学科老龄化研究发展的网络和基础设施支持”。穿过
在R24中,我们成功地将CFAR和OAIC联系起来,以支持高优先级重点领域的试点项目
在艾滋病毒和老龄化的界面上指导研究人员。我们对这项提议的愿景是在这一成功的基础上再接再厉
深化CFARs和OAICs之间的持续联系,并将网络扩大到包括Nathan Shock
老龄化基础生物学卓越中心(NSCs)和麦克奈特脑研究所(MBIS)。通过
将OAICs在衰老功能衰退方面的专业知识与NSC在衰老生物学和
功能下降的潜在机制,具有MBI在年龄相关认知下降方面的专业知识,以及CFAR
作为艾滋病毒方面的专业知识,我们创建了一种综合方法来推进和加快
通过以下目标实现艾滋病毒与老龄化的对接:
目标1.提供具体的培训模式和简要的工具清单,以便有效地收集数据以改进艾滋病毒
临床护理和结果研究。目标2.使用老年科学方法,为先导研究提供平台
为了确定衰老的分子特征与功能衰退之间的联系,以及糖尿病的发展
老年PLWH常见的并存疾病。目标3.开发评估干预措施的基础设施
艾滋病毒护理的方法及其应用。目标4.提供教育支持、实施建议和
指导新出现的研究人员建立/推进艾滋病毒和老龄化研究计划。
这些协同作用的目标是利用和扩大艾滋病毒专门知识R24中建立的基础设施和密切联系
来自具有OALC内老年学和功能评估专业知识的CFAR,并通过以下方式扩展它们
纳入NSCs和MBIS,以加强和加快艾滋病毒与老龄化交界处的调查。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.
在一项纵向临床队列研究中评估艾滋病毒感染者虚弱状态的病戒假说和减少饮酒。
- DOI:10.1097/jnc.0000000000000445
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Ruderman,StephanieA;Drumright,LydiaN;Delaney,JosephAC;Webel,AllisonR;Fitzpatrick,AnnetteL;Whitney,BridgetM;Nance,RobinM;Hahn,AndrewW;Ma,Jimmy;Mixson,L.Sarah;Eltonsy,Sherif;Willig,AmandaL;Mayer,KennethH;Napravnik,Sonia
- 通讯作者:Napravnik,Sonia
Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States.
- DOI:10.1097/jnc.0000000000000389
- 发表时间:2023-03-01
- 期刊:
- 影响因子:2
- 作者:Ruderman, Stephanie A.;Webel, Allison R.;Willig, Amanda L.;Drumright, Lydia N.;Fitzpatrick, Annette L.;Odden, Michelle C.;Cleveland, John D.;Burkholder, Greer;Davey, Christine H.;Fleming, Julia;Buford, Thomas W.;Jones, Raymond;Nance, Robin M.;Whitney, Bridget M.;Mixson, L. Sarah;Hahn, Andrew W.;Mayer, Kenneth H.;Greene, Meredith;Saag, Michael S.;Kamen, Charles;Pandya, Chintan;Lober, William B.;Kitahata, Mari M.;Crane, Paul K.;Crane, Heidi M.;Delaney, Joseph A. C.
- 通讯作者:Delaney, Joseph A. C.
Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.
吸烟和吸烟年数与艾滋病毒感染者的虚弱有关。
- DOI:10.1097/qai.0000000000003242
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Ruderman,StephanieA;Odden,MichelleC;Webel,AllisonR;Fitzpatrick,AnnetteL;Crane,PaulK;Nance,RobinM;Drumright,LydiaN;Whitney,BridgetM;Mixson,LyndseySarah;Ma,Jimmy;Willig,AmandaL;Haidar,Lara;Eltonsy,Sherif;Mayer,KennethH;
- 通讯作者:
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STEVEN N. AUSTAD其他文献
STEVEN N. AUSTAD的其他文献
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{{ truncateString('STEVEN N. AUSTAD', 18)}}的其他基金
A New Translational Rat Model for Evaluating Anti-Aging Interventions
用于评估抗衰老干预措施的新转化大鼠模型
- 批准号:
10665539 - 财政年份:2022
- 资助金额:
$ 76.99万 - 项目类别:
A New Translational Rat Model for Evaluating Anti-Aging Interventions
用于评估抗衰老干预措施的新转化大鼠模型
- 批准号:
10369517 - 财政年份:2022
- 资助金额:
$ 76.99万 - 项目类别:
A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and Longevity
研究健康和长寿性别差异的四核心基因型 (FCG) 方法
- 批准号:
9504206 - 财政年份:2018
- 资助金额:
$ 76.99万 - 项目类别:
A sex difference approach to evaluating resilience as a predictor of healthspan in mice
评估弹性作为小鼠健康寿命预测因子的性别差异方法
- 批准号:
10166754 - 财政年份:2017
- 资助金额:
$ 76.99万 - 项目类别:
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