The Kentucky ECHO Pediatric IDeA Research Center (KE-PIRC)

肯塔基州 ECHO 儿科 IDeA 研究中心 (KE-PIRC)

• 批准号: 10683291
• 负责人: Lori Ann Devlin-Phinney
• 金额: $ 43.04万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683291
• 关键词: Academic Medical Centers; Acceleration; Address; Adolescent; Adult; Airway Disease; Alcohol consumption; Appalachian Region; Area; Child; Child Health; Child health care; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Communities; Development; Diabetes Mellitus; Disease; Drug abuse; Education; Educational Status; Environment; Environmental Health; Etiology; Faculty; Family; Feedback; Fetal Development; Funding; Generations; Goals; Health; Health Benefit; Healthcare; Heart Diseases; High Prevalence; Individual; Infant; Institution; Intervention; Kentucky; Leadership; Malignant neoplasm of lung; Mentors; Mentorship; Multi-Institutional Clinical Trial; Neonatal; Neurologist; Obesity; Occupational Exposure; Outcome; Participant; Patients; Pediatric Hospitals; Perinatal; Physicians; Population; Population Heterogeneity; Preventive; Primary Care; Process; Provider; Refugees; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Community; Rural Population; Scientist; Site; Smoking; Stroke; System; Talents; Teacher Professional Development; Time; Training; Training and Education; Underrepresented Minority; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Vulnerable Populations; Work; autism spectrum disorder; biomedical referral center; care outcomes; career; cohort; community engagement; community partnership; ethnic minority; fetal; improved; innovation; member; next generation; novel strategies; nutrition; outreach program; patient population; pediatrician; postnatal; programs; racial minority; recruit; rural area; rural underserved; senior faculty; skills; success; underserved area; urban underserved

PROJECT SUMMARY/ABSTRACT As a predominantly rural state, Kentucky leads the nation in many pediatric and adult chronic and environmentally-related diseases and ‘ranks nationally’ in low educational achievement. These adverse factors combine to make Kentuckians especially unhealthy residents with a high prevalence of obesity, diabetes, smoking, alcohol use, heart disease, stroke, lung cancer, etc. Many of these diseases are environmentally related to poor nutrition, obesity, smoking, drug abuse, and work-place exposures. Kentucky also leads the nation in the percentage of pediatric populations with special health care needs. Prior work has shown that most adult diseases have their origin in childhood and some begin during fetal development, making childhood the ideal time for intervention with the goal of improving health outcomes into adulthood. Improving healthcare outcomes and wellness in children is contingent on expanding and sustaining high quality clinical research that includes diverse populations. Pediatricians at the University of Louisville (UofL) with our Healthcare Partners serve a highly diverse patient population that includes the rural and urban poor, a unique Appalachian community, refugees, and numerous ethnic minorities. To better serve this population, we propose to build upon our current programs, expand our bidirectional community engagement efforts, collaborate with other institutions on pediatric clinical trials through the ECHO IDeA Pediatric Clinical Trials Network, and collaborate with ECHO cohort, INBRE, and CTSA sites to advance healthcare for children. Education and training of local and regional faculty and staff is critical to sustain this initiative. The Kentucky ECHO-Pediatric IDeA Research Center (KE-PIRC), as part of the IDeA States Pediatric Clinical Trials Network, will make it possible for 1) rural and underserved infants, children and adolescents to participate in clinical research; 2) junior investigators to be trained in clinical research and community engagement, improve the health of both children and adults in Kentucky through this research, and develop their academic career; and 3) the development of a regional network of partners to sustain this clinical research initiative. The five primary focus areas are 1) pre-, peri- and postnatal outcomes; 2) neurodevelopmental; 3) upper and lower airway disease; 4) obesity; and 5) positive health. These primary focus areas are highly prevalent in Kentucky; therefore, KE-PIRC will enable strengthening current collaborations and accelerate the development of new networks within the state through bidirectional community engagement and feedback to support pediatric clinical research. Through these efforts, we aim to improve the health outcomes of Kentucky children and adults and establish a local and national sustainable pediatric clinical research workforce.

项目总结/摘要 作为一个以农村为主的州，肯塔基州在许多儿童和成人慢性和 与环境有关的疾病和“全国排名”的低教育成就。这些不利因素 联合收割机使肯塔基州居民特别不健康，肥胖，糖尿病， 吸烟、酗酒、心脏病、中风、肺癌等。其中许多疾病都与环境有关 与营养不良、肥胖、吸烟、药物滥用和工作场所接触有关。肯塔基州也领先于 有特殊保健需要的儿童人口的百分比。先前的工作表明， 大多数成人疾病起源于儿童期，有些开始于胎儿发育期间， 这是进行干预的理想时间，目的是改善成年后的健康状况。 改善儿童的医疗保健结果和健康取决于扩大和维持高水平的医疗保健服务。 包括不同人群的优质临床研究。路易斯维尔大学（UofL）的儿科医生 我们的医疗保健合作伙伴为高度多样化的患者群体提供服务，包括农村和城市贫困人口， 独特的阿巴拉契亚社区，难民和众多的少数民族。为了更好地服务这一群体，我们 建议在我们现有计划的基础上，扩大我们的双向社区参与努力， 通过ECHO IDEA儿科临床试验与其他机构合作开展儿科临床试验 与ECHO队列、INBRE和CTSA研究中心建立网络并开展合作，以推进儿童医疗保健。 对地方和区域教职员工的教育和培训对于维持这一举措至关重要。 肯塔基州ECHO-儿科IDEA研究中心（KE-PIRC），作为IDEA州儿科临床研究中心的一部分， 试验网络，将使1）农村和服务不足的婴儿，儿童和青少年， 参与临床研究; 2）初级研究者接受临床研究和社区培训 参与，通过这项研究改善肯塔基州儿童和成人的健康，并发展 他们的学术生涯;和3）发展合作伙伴的区域网络，以维持这种临床 研究倡议。五个主要重点领域是：1）产前、产中和产后结果; 2） 神经发育; 3）上和下呼吸道疾病; 4）肥胖症;和5）积极健康。这些主要 重点领域在肯塔基州非常普遍;因此，KE-PIRC将能够加强当前 通过双向合作，加快国家内部新网络的发展 社区参与和反馈，以支持儿科临床研究。通过这些努力，我们的目标是 改善肯塔基州儿童和成人的健康状况，并建立一个地方和国家可持续的 儿科临床研究人员。

项目成果

Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.

• DOI: 10.1007/s40272-021-00460-4
• 发表时间: 2021-09
• 期刊: PEDIATRIC DRUGS
• 影响因子: 3.7
• 作者: Maharaj, Anil R.;Wu, Huali;Zimmerman, Kanecia O.;Muller, William J.;Sullivan, Janice E.;Sherwin, Catherine M. T.;Autmizguine, Julie;Rathore, Mobeen H.;Hornik, Chi D.;Al-Uzri, Amira;Payne, Elizabeth H.;Benjamin, Daniel K., Jr.;Hornik, Christoph P.
• 通讯作者: Hornik, Christoph P.