A Community Resource for Single Cell Data in the Brain

大脑中单细胞数据的社区资源

• 批准号: 10684769
• 负责人: Michael Hawrylycz
• 金额: $ 215.78万
• 依托单位: ALLEN INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684769
• 关键词: Accountability; Agreement; Archives; Atlases; BRAIN initiative; Brain; Catalogs; Cells; Censuses; Collaborations; Communication; Communities; Complement; Data; Data Collection; Data Storage and Retrieval; Decision Making; Development; Disease; Documentation; Education and Outreach; Educational Activities; Ensure; Equipment and supply inventories; FAIR principles; Future; Generations; Goals; Health; Human; Information Networks; Infrastructure; Laboratories; Maintenance; Metadata; Molecular; Monitor; Mus; Ontology; Persons; Process; Production; Publications; Publishing; Reporting; Research; Research Personnel; Resources; Role; Route; Site; Structure; Taxonomy; Training Activity; Work; cell type; dashboard; data curation; data ingestion; data sharing; data submission; experience; improved; interoperability; meetings; member; metadata standards; nonhuman primate; ontology development; operation; outreach; programs; statistics; symposium; tool; virtual; working group

Project Summary The BRAIN Initiative Cell Atlas Network (BICAN) will generate comprehensive molecular taxonomies and organizational principles of cell type diversity in the human and non-human primate extending comprehensive BICCN work in the mouse. This detailed census of the structure and role of cell type specific data in the brain is recognized as one of the most promising avenues for advancing our understanding of the human brain in health and disease. To facilitate successful operations for BICAN, this project will establish an engagement, outreach, and coordination unit for the consortium that will manage operations, essential standards development and documentation, provide operational transparency, and identify and coordinate solutions to key hurdles for collaboration and analysis. In addition to organizing virtual and in-person meetings of the BICAN network and working groups this unit will improve interoperability and alignment with other consortia and partners and aim to improve usage for a wide range of potential data consumers. Complementing these fundamental operational goals of the BICAN consortium and partner CUBIE units, this unit will provide a governance structure for generation and operational transparency of BICAN data production and release and standards development. Essential activities will include technical management and facilitation of community standards, schemas, and ontology development, and centralized consortium data registration and dashboard, and coordinating and organizing BICAN outreach, training, and education activities to enhance interactions with external research programs and consortia. The resulting consortium generated data and tools will be made publicly accessible in a community portal supporting data retrieval, consortium activities, amplify public impact through strong BICAN partnership management, communication, standards committees, and analysis working groups, and develop infrastructure for maximizing community usage, publishing standards and tutorials, and coordinating education and outreach.

项目摘要 大脑倡议细胞地图集网络（BICAN）将产生全面的分子分类法和 人类和非人类灵长类动物中细胞类型多样性的组织原理，扩展了全面 BICCN在鼠标中起作用。大脑中细胞类型特定数据的结构和作用的详细普查 被公认为是推进我们对人类大脑理解的最有前途的途径之一 健康与疾病。为了促进Bican成功运营，该项目将建立参与度， 将管理运营，基本标准的联盟的外展和协调单位 开发和文档，提供运营透明度，并确定和协调解决方案 协作和分析的关键障碍。除了组织虚拟和面对面的会议 BICAN网络和工作组该单元将改善与其他财团的互操作性和对齐方式 和合作伙伴，旨在改善广泛的潜在数据消费者的使用情况。补充这些 BICAN财团和合作伙伴Cubie单位的基本运营目标，本单元将提供一个 BICAN数据生产和释放的生成和运营透明度的治理结构 标准发展。基本活动将包括技术管理和促进社区的促进 标准，模式和本体发展以及集中的财团数据注册和仪表板， 以及协调和组织比肯人的外展，培训和教育活动，以增强互动 与外部研究计划和财团。由此产生的联盟生成的数据和工具将是 在支持数据检索，财团活动的社区门户网站上公开访问，扩大公众 通过强大的BICAN合作管理，沟通，标准委员会和分析的影响 工作组，并开发基础架构，以最大化社区使用，发布标准和 教程，并协调教育和外展。