Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymers

改善颅内动脉瘤血管内治疗的效果：结合增材制造、计算机建模和形状记忆聚合物

• 批准号: 10685325
• 负责人: Chung-Hao Lee
• 金额: $ 66.03万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-23 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685325
• 关键词: 3-Dimensional; 3D Print; Accounting; Acute; Affect; American; Aneurysm; Animals; Arteries; Biomechanics; Brain; Brain Aneurysms; Brain Injuries; Brain hemorrhage; Calibration; Catheters; Cause of Death; Circulation; Classification; Clinical; Clinical Treatment; Collaborations; Complex; Data; Development; Devices; Dilatation - action; Effectiveness; Elastases; Elements; Evaluation Studies; Expenditure; Gel; Geometry; Goals; Hospitals; Implant; In Vitro; Incidence; Indiana; Individual; Intracranial Aneurysm; Left; Liquid substance; Mechanics; Medicine; Memory; Methods; Modeling; Morphology; Neck; New Zealand; Oklahoma; Oryctolagus cuniculus; Patients; Performance; Polymers; Porosity; Premature Mortality; Preventive; Printing; Process; Property; Protocols documentation; Recovery; Recurrence; Reporting; Research; Research Personnel; Residual state; Retreatment; Rupture; Ruptured Aneurysm; Sampling; Science; Shapes; Stroke; Structure; Subarachnoid Hemorrhage; System; Techniques; Testing; Therapeutic Embolization; Tissues; Treatment outcome; United States; Universities; Urethane; compare effectiveness; design; disability; experience; experimental study; fabrication; hemodynamics; improved; improved outcome; in silico; in vivo; iterative design; manufacture; manufacturing process; mechanical properties; microdevice; minimally invasive; mortality; nervous system disorder; neurosurgery; novel; prevent; prophylactic; thrombogenesis; translational medicine

Project Summary/Abstract Subarachnoid hemorrhage (SAH) is a devasting acute neurological disease that remains a major cause of premature mortality. SAH is most caused by incidental rupture of an intracranial aneurysm (ICA). The mortality rate of aneurysm rupture can reach as high as 40% within the first week of incidence. Even if the aneurysm is treated in a timely manner, the chance of moderate to severe brain damage is 20-35%. Endovascular coil embolization is the current gold-standard, minimally invasive therapy of ICAs; however, emerging clinical challenges of coil embolization are unsatisfactory aneurysm recurrence rates: ~44% by 5-6 years after the initial coil therapy (of which more than 50% requiring re-treatment), and suboptimal complete occlusion, especially for treating wide-necked ICAs and/or aneurysms with a complex 3D geometry. Thus, there is a need for a durable device to treat unruptured ICAs that targets patient-specific aneurysms and intra-aneurysmal circulation and provides long-lasting complete occlusion. Our research objectives of this project are to: 1) design and fabricate personalized embolic devices for treating saccular, bifurcated IACs using additive manufacturing and a combined experimental/biomechanical approach, and 2) provide a holistic biomechanical and hemodynamic comparison between our device and other selected endovascular embolic techniques. This proposal builds upon the assembled preliminary data, and leverages Dr. Lee’s experience with tissue biomechanics and in-silico modeling, in collaboration with polymer science and additive manufacturing researchers at the University of Oklahoma, clinical and neurosurgical expertise of clinicians at Indiana University – Medicine, and micro-device and catheter expert at Purdue. Specifically, we propose to design, develop, and evaluate patient-specific SMP embolic devices using 3D printing-based polymer fabrication. Our embolic devices are designated to target personalized aneurysm filling and maximize the rate of long-lasting complete occlusion. Next, through in-vitro flow loop testbed and in-vivo small animal studies, the efficacy and aneurysm occlusion of our personalized embolic devices will be systematically evaluated in comparison to the clinical gold standard as well as three other contemporary embolic methods. The endpoint of this project will be a cutting-edge solution for ICA embolization, that uses fundamental information on aneurysms based on holistic biomechanical and hemodynamic analyses – allowing individual-optimized aneurysm filling to achieve immediate & long-term complete occlusion and reduce aneurysm recurrence. Collectively, our developments will serve as a logical first step toward attaining our long- term goal to advance the state of the art in translational medicine by facilitating personalized, preventive management of unruptured ICAs and reduce aneurysm rupture-induced hemorrhagic strokes.

项目总结/文摘

项目成果

An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets

使用 CellScale BioTester 和猪三尖瓣小叶的本构模型研究样本尺寸如何影响双轴机械特性

• DOI: 10.1016/j.jbiomech.2023.111829
• 发表时间: 2023
• 期刊: Journal of Biomechanics
• 影响因子: 2.4
• 作者: Laurence, Devin W.;Wang, Shuodao;Xiao, Rui;Qian, Jin;Mir, Arshid;Burkhart, Harold M.;Holzapfel, Gerhard A.;Lee, Chung-Hao
• 通讯作者: Lee, Chung-Hao

MetaNO: How to Transfer Your Knowledge on Learning Hidden Physics.

MetaNO：如何转移您学习隐藏物理的知识。

• DOI: 10.1016/j.cma.2023.116280
• 发表时间: 2023
• 期刊: Computer methods in applied mechanics and engineering
• 影响因子: 7.2
• 作者: Zhang,Lu;You,Huaiqian;Gao,Tian;Yu,Mo;Lee,Chung-Hao;Yu,Yue
• 通讯作者: Yu,Yue

Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.

• DOI: 10.1016/j.actbio.2022.07.036
• 发表时间: 2022-09-15
• 期刊: ACTA BIOMATERIALIA
• 影响因子: 9.7
• 作者: Pineda-Castillo, Sergio A.;Aparicio-Ruiz, Santiago;Burns, Madison M.;Laurence, Devin W.;Bradshaw, Elizabeth;Gu, Tingting;Holzapfel, Gerhard A.;Lee, Chung-Hao
• 通讯作者: Lee, Chung-Hao