课题基金 / 基金详情

项目摘要

项目成果

Joel D Mainland的其他基金

相似基金

相关文献

中文摘要
翻译
项目摘要 现代技术使人们有可能捕捉一个视觉场景作为一张照片,改变它,把它发送到另一个 国家几乎瞬间,并存储它,而不必担心退化。这些目前都不可能实现 在嗅觉方面。尽管调香师和调味师擅长混合气味分子以产生所需的香味, 虽然这是一种感性的影响,但在定量层面上对这一过程的基本规则了解甚少。电流 用于向受试者显示气味的方法类似于需要感兴趣的每个视觉刺激的宝丽来。一 探测嗅觉系统的更有效的方法是使用一组“主要气味”--一些有限的 通过适当的混合物可以再现所有其他复杂气味的气味数量。两 听觉和视觉刺激已经被数字化,这最终也将在嗅觉中成为可能。 从化学结构预测气味从一开始就一直是该领域的一个问题,但最近的进展 在机器学习中,算法在类似的问题上取得了很大的进展,例如面部识别。 本文提出的研究将联合收割机这些机器学习技术与高质量的人类 心理物理学,以了解如何预测分子或气味混合物的气味,这将 最终有助于提高我们对疾病诊断的理解, 和疾病
英文摘要
PROJECT SUMMARY Modern technology makes it possible to capture a visual scene as a photograph, alter it, send it to another country nearly instantaneously, and store it without concern for degradation. None of this is currently possible in olfaction. Although perfumers and flavorists are adept at mixing odorous molecules to produce a desired perceptual effect, the rules underlying this process are poorly understood at a quantitative level. Current methods for displaying odors to a subject are akin to requiring a Polaroid of every visual stimulus of interest. A more efficient method for probing the olfactory system would be to use a set of 'primary odors'—some limited number of odors from which all other complex odors could be reproduced by appropriate mixtures. Both auditory and visual stimuli have been digitized, and this will eventually be possible in olfaction as well. Predicting odor from chemical structure has been a problem in the field since its inception, but recent advances in machine learning algorithms have made great progress in analogous problems, such as facial recognition. The research proposed here will combine these machine learning techniques with high quality human psychophysics to understand how to predict the smell of a molecule or mixture of odorants, which will ultimately help improve our understanding of disease diagnosis using odors as well as eating-related health and illness.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Predicting Human Olfactory Perception from Molecular Structure
  • 批准号:
    10249061
  • 项目类别:
  • 资助金额:
    $43.74万
  • 财政年份:
    2020
  • 负责人:
    Joel D Mainland
  • 依托单位:
Predicting Human Olfactory Perception from Molecular Structure
  • 批准号:
    9887973
  • 项目类别:
  • 资助金额:
    $49.69万
  • 财政年份:
    2020
  • 负责人:
    Joel D Mainland
  • 依托单位:
Diversity Supplement to R01 DC017757
  • 批准号:
    10610599
  • 项目类别:
  • 资助金额:
    $1.14万
  • 财政年份:
    2020
  • 负责人:
    Joel D Mainland
  • 依托单位:
Predicting Human Olfactory Perception from Molecular Structure
  • 批准号:
    10468260
  • 项目类别:
  • 资助金额:
    $43.35万
  • 财政年份:
    2020
  • 负责人:
    Joel D Mainland
  • 依托单位:
海外基金