Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder
药物滥用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估
基本信息
- 批准号:10685347
- 负责人:
- 金额:$ 19.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:Amygdaloid structureAnimalsAnteriorAttentionBiological MarkersBiologyBoard CertificationBrainBrain regionCenters for Disease Control and Prevention (U.S.)Cessation of lifeClinicalCocaine use disorderCorpus striatum structureCouplingCuesDataDevelopmentDiagnosisDiseaseDrug usageEthicsExtinctionFunctional Magnetic Resonance ImagingGlutamatesGoalsHeroin UsersHippocampusHumanImageInsula of ReilIntakeKnowledgeMagnetic ResonanceMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurableMeasuresMedicalMentorsMethodsModalityModelingNatureNeuronsNeurosciencesNeurotransmittersOpioidOxycodonePathway interactionsPatientsPharmaceutical PreparationsPhysicsPhysiologicalPhysiologyPrediction of Response to TherapyPrefrontal CortexReaction TimeRelapseReportingResearchResearch PersonnelRodentSelf AdministrationSerotonin AgonistsServicesSocietiesStimulusSubstance Use DisorderTechniquesTrainingTraining ProgramsUnited StatesWorkaddictionattentional biascausal modelcingulate cortexcravingcue reactivitydesigndrug cravinggamma-Aminobutyric Acidimaging studyindicated preventionmortalitymultimodalityneural circuitneuroimagingneuromechanismneuronal circuitryopioid useopioid use disorderpublic health emergencyrelapse predictionresearch studyresponsesocialsubstance usetargeted treatmenttheoriestoolvisual stimulus
项目摘要
Opioid use disorder (OUD) has been declared as a public health emergency in the United States. Data from
the Centers for Disease Control and Prevention indicate a fivefold increase in the number of deaths due to
opioids from 1999 to 2016. Neuroimaging is a powerful tool in understanding the neurocircuitry and physiology
of OUD in order to target treatments for patients suffering from this disorder. This K23 application presents a
training program for a board-certified clinical medical physicist, who specializes in magnetic resonance imaging
(MRI), in order to receive training in the neuroscience of substance use disorders and to become an
independent investigator. The goals set in this application will build on the candidate’s imaging physics
background by (1) developing a foundational knowledge of brain function and neurocircuitry in substance use
disorders in order to design, optimize, and interpret advanced neuroimaging techniques for addiction research;
(2) acquiring training in professional development to become an independent investigator, mentor and
educator; and (3) receiving additional training in the responsible and ethical conduct of scientific research. The
overall training program will involve a research study focused on (1) brain effective connectivity (i.e., directional
connectivity) of neural circuits in OUD, and (2) magnetic resonance spectroscopic quantification of
neurotransmitters related to these circuits. In this proposed work, we will employ fMRI-based dynamic causal
modeling of effective connectivity with guided expertise from mentors in order to identify neurocircuits
underlying drug craving and attentional bias to dug cues. In addition, we will use MR spectroscopy to
investigate the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate in OUD and their relation
to drug craving and attentional bias, and to explore the association of these neurotransmitters with brain
effective connectivity.
阿片类药物使用障碍(OUD)在美国已被宣布为公共卫生紧急情况。数据来自
美国疾病控制和预防中心表示,因疟疾死亡人数增加了五倍
1999年至2016年的阿片类药物。神经成像是了解神经回路和生理学的有力工具。
为了有针对性地治疗患有这种疾病的患者。此K23应用程序提供了
专门从事磁共振成像的委员会认证的临床医学物理学家的培训计划
(MRI),以便接受药物使用障碍的神经科学培训,并成为
独立调查员。此应用程序中设定的目标将建立在候选人的成像物理基础上
背景知识:(1)在物质使用中发展大脑功能和神经回路的基础知识
为成瘾研究设计、优化和解释先进的神经成像技术;
(2)接受专业发展培训,成为独立的调查员、导师和
教育工作者;以及(3)接受负责任和合乎道德的科学研究行为的额外培训。这个
整个培训计划将包括一项研究研究,重点是(1)大脑有效连接(即,方向性
OUD中神经回路的连通性),以及(2)磁共振光谱定量
与这些回路相关的神经递质。在这项拟议的工作中,我们将使用基于fMRI的动态因果关系
利用导师指导的专业知识对有效连通性进行建模,以便识别神经回路
潜在的药物渴求和注意力偏向于挖掘线索。此外,我们将使用磁共振光谱学来
乌拉米中神经递质γ-氨基丁酸和谷氨酸及其相互关系的研究
药物渴求和注意偏向,并探讨这些神经递质与大脑的关系
有效连接。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brian Allen Taylor其他文献
Brian Allen Taylor的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Brian Allen Taylor', 18)}}的其他基金
Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with Opioid Use Disorder
阿片类药物使用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估
- 批准号:
9975514 - 财政年份:2020
- 资助金额:
$ 19.02万 - 项目类别:
Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder
药物滥用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估
- 批准号:
10229537 - 财政年份:2020
- 资助金额:
$ 19.02万 - 项目类别:
Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder
药物滥用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估
- 批准号:
10457894 - 财政年份:2020
- 资助金额:
$ 19.02万 - 项目类别:
Automated Assessment of White Matter Integrity in TBI Using Machine Learning
使用机器学习自动评估 TBI 中白质完整性
- 批准号:
9281656 - 财政年份:2014
- 资助金额:
$ 19.02万 - 项目类别:
Automated Assessment of White Matter Integrity in TBI Using Machine Learning
使用机器学习自动评估 TBI 中白质完整性
- 批准号:
8732156 - 财政年份:2014
- 资助金额:
$ 19.02万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 19.02万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 19.02万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 19.02万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 19.02万 - 项目类别:
Discovery Early Career Researcher Award
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Continuing Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia
使用雌性传染性低体温模型动物分析中枢神经系统的体温调节机制
- 批准号:
23KK0126 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 19.02万 - 项目类别:
Training Grant