Building Research in Implementation and Dissemination to close Gaps and achieve Equity in Cancer Control (BRIDGE-C2) Center

总体项目摘要 在实施和传播方面进行研究，以缩小差距并实现癌症平等 控制中心（BRIDGE-C2）将承担推进实施科学的重大挑战， 改善服务不足人群的癌症筛查和预防。这项工作是迫切需要的 由于癌症筛查和预防在提供循证医学方面存在差异， 干预措施（EBI）。改善EBI在初级保健社区卫生中实施的有效策略 可以消除这些差异的中心（CHC）不为人知或知之甚少。执行 科学可以提供新的知识，改变社区卫生服务中心为国家最脆弱群体服务的能力 人口数量。BRIDGE-C2中心将：1）创建一个可持续的基础设施，用于开发，进行， 不断评估提高初级保健公平提供服务能力的实施战略 向所有人提供循证癌症筛查和预防干预措施，强调缩小护理差距 2）建立能力和培训机会，并让一个多学科的团队参与， 执行科学和方法专家，以促进制定有关 我们的重大挑战; 3）确定改善癌症筛查实施的战略， 预防EBI在初级保健，并进行研究/开发务实的方法，以定制，加强， 支持这些战略的采用和可持续性。我们将在现有的牢固伙伴关系基础上再接再厉， 俄勒冈州健康与科学（OHSU）初级保健、OHSU奈特癌症研究所、 和OCHIN实施实验室（一个由超过500个社区卫生中心组成的完善的国家网络， 通过OCHIN基于实践的研究网络的电子健康记录）。BRIDGE-C2中心 开展试点研究，制定和测试改善EBI实施的战略， 成功的试点，进行大规模的务实试验，并广泛传播有效的创新， 初级保健做法照顾得不到充分服务的人口。贯穿这些活动的将是 中心专注于指导和培训早期职业实施科学家并利用合作 提高科学执行能力。该中心的行政核心将作为核心， 连接研究计划和实施实验室，为研究活动提供支持， 领导、治理、调查员发展、传播、评价以及与国家 ISCCC网络。我们的前两个研究试点旨在改善宫颈癌筛查和后续护理， 戒烟。我们的前两个方法试点将创造新的能力来预测所需的实施 基于供应商和实践特征的支持。我们将传播我们的发现， 向科学、专业和社区网络广泛传播我们的发现和创新， 增加癌症筛查和预防EBI的实施，减少健康差距。

OVERALL PROJECT SUMMARY The Building Research in Implementation and Dissemination to close Gaps and achieve Equity in Cancer Control (BRIDGE-C2) Center will take on the grand challenge of advancing implementation science to improve cancer screening and prevention in underserved populations. This work is urgently needed because cancer screening and prevention disparities exist with regard to delivery of evidence-based interventions (EBIs). Effective strategies to improve implementation of EBIs in primary care community health centers (CHCs) that can eliminate these disparities are not known or poorly understood. Implementation science can contribute new knowledge that will transform CHCs' ability to serve the nation's most vulnerable populations. The BRIDGE-C2 Center will: 1) create a sustainable infrastructure for developing, conducting, and continuously evaluating implementation strategies that enhance primary care's ability to equitably deliver evidence-based cancer screening and prevention interventions to all people, emphasizing closing care gaps for vulnerable populations; 2) build capacity and training opportunities, and engage a multi-disciplinary team of implementation science and methods experts, to facilitate the development of innovative approaches relevant to our grand challenge; and 3) identify strategies to improve implementation of cancer screening and prevention EBIs in primary care, and conduct research / develop pragmatic methods to tailor, enhance, and support the adoption and sustainability of these strategies. We will build on the strong established partnerships between researchers at Oregon Health & Science (OHSU) primary care, the OHSU Knight Cancer Institute, and the OCHIN Implementation Laboratory (a well-established national network of >500 CHCs that share an electronic health record through the OCHIN Practice-Based Research Network). The BRIDGE-C2 Center will conduct pilot studies that develop and test strategies to improve implementation of EBIs, rapidly scale up successful pilots to conduct large scale pragmatic trials, and widely disseminate effective innovations to primary care practices caring for underserved populations. Woven throughout these activities will be the Center's focus on mentoring and training early career implementation scientists and leveraging collaborations to increase implementation science capacity. The Center's Administrative Core will serve as the nucleus that bridges the Research Program and Implementation Laboratory, providing support for research activities, leadership, governance, investigator development, dissemination, evaluation, and a connection to the national ISCCC network. Our first two research pilots aim to improve cervical cancer screening and follow-up care and tobacco cessation. Our first two methods pilots will create novel capabilities to predict needed implementation support based on provider and practice characteristics. We will spread our discoveries and create mechanisms for widely disseminating our findings and innovations to scientific, professional, and community networks to increase implementation of cancer screening and prevention EBIs and decrease health disparities.