The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

烟酰胺核苷对老年退伍军人认知和睡眠的益处

• 批准号: 10686985
• 负责人: Carleara Weiss
• 金额: $ 10.45万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10686985
• 关键词: Academy; Activities of Daily Living; Adult; Age; Alzheimer' s Disease; American; Amyloid beta-42; Animal Model; Applied Research; Award; Basic Science; Behavioral; Biochemistry; Biological; Biological Markers; Biometry; Brain-Derived Neurotrophic Factor; Circadian Dysregulation; Circadian Rhythms; Clinical; Cognition; Conduct Clinical Trials; Data; Dementia; Discipline of Nursing; Elderly; Elements; Enrollment; Environment; Exhibits; Fellowship; Female; Foundations; Funding; Geriatric Assessment; Geriatrics; Goals; Growth; Hippocampus; Human; Impaired cognition; Impairment; Individual; International; Intervention; Knowledge; Language; Leadership; Learning; Measurement; Measures; Medicine; Memory; Memory impairment; Mentors; Mitochondria; Molecular; Molecular Biology; Mus; Niacinamide; Nicotinamide adenine dinucleotide; Nurses; Parents; Participant; Physical Performance; Pittsburgh Sleep Quality Index; Placebos; Psyche structure; Questionnaires; Research; Research Project Grants; Risk; Role; Science; Scientist; Serum; Severities; Silver; Sleep; Sleep disturbances; Sleeplessness; Societies; Supplementation; Synaptic plasticity; Techniques; Testing; Training; Training Programs; Treatment Cost; Tsunami; Underrepresented Minority; Universities; Veterans; Work; aged; aging population; career development; clinical development; clinical training; cognitive function; cognitive performance; diversity and inclusion; empowerment; executive function; experience; fitbit; functional outcomes; healthy aging; human old age (65+); improved; improvement on sleep; indexing; innovation; instrument; intervention cost; male; mild cognitive impairment; monocyte; nicotinamide riboside supplementation; nicotinamide-beta-riboside; peripheral blood; placebo group; poor sleep; potential biomarker; pre-clinical; prevent; programs; randomized, clinical trials; screening; skills; sleep quality; tau-1; wearable device

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project. My primary mentor, Dr. Bruce Troen (Geriatrics) is an internationally recognized geriatrician and geroscientist. He will be assisted by co-mentors Dr. Rebecca Lorenz (Nursing, Geriatric, Sleep), Dr. Brienne Miner (Geriatrics, Sleep), Dr. Kenneth Seldeen (Geriatrics, Biochemistry); and advisors Dr. Nikhil Satchidanand (Geriatrics, Cognition), and Dr. Chang-Xing Ma (Biostatistics). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successul execution of the career development and reseach project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose to build upon a VA-funded randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, upon physical performance in older adults, by examining the benefits of NR on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three-month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.

项目概要/摘要 候选人：我的首要目标是作为独立人士通过优质睡眠促进健康老龄化 护士科学家。我在老年病学和行为睡眠医学方面的临床培训以及我的临床前培训 睡眠和昼夜节律紊乱方面的研究为我实现这一目标的专业知识奠定了基础。这 该提案将允许对应用于人类研究的基础科学进行培训，以支持对 老年人睡眠不良和认知障碍的分子机制及其潜在机制 互动。本申请中提出的职业发展将使我成长为新兴人才 来自代表性不足的背景的领导者，曾获得睡眠研究协会的奖项，并且 美国睡眠医学会。 导师和环境：为此组建了一支由导师和顾问组成的杰出团队 项目。我的主要导师 Bruce Troen 博士（老年病学）是一位国际公认的老年病学家， 老年科学家。他将得到共同导师 Rebecca Lorenz 博士（护理、老年科、睡眠）、Dr. Rebecca Lorenz 的协助。 Brienne Miner（老年病学、睡眠）、Kenneth Seldeen 博士（老年病学、生物化学）；和顾问博士。 Nikhil Satchidanand（老年病学、认知）和 Chang-Xing Ma 博士（生物统计学）。我们创建了一个 以布法罗大学和耶鲁大学为基础的培养研究和领导技能的培训计划 大学老年病学和睡眠研究项目，以成功实现职业发展 以及本申请中概述的研究项目。 指导研究项目：睡眠质量差和睡眠时间短与认知能力有关 老年人的损伤，可能是阿尔茨海默病和其他疾病的潜在机制 由于线粒体功能受损和/或脑源性神经营养物质表达减少而导致痴呆 因子（BDNF）。我们之前的工作表明，提高烟酰胺腺嘌呤的可用性 二核苷酸（NAD+）可改善老年小鼠的身体表现和认知能力，并可能减少 通过增强线粒体功能和增强 BDNF 来改善认知能力下降并支持睡眠质量 表达。我们建议以 VA 资助的随机临床试验为基础，调查以下因素的影响： 补充 NAD+ 前体、烟酰胺核苷（维生素 B3 的一种形式） 通过检查 NR 对睡眠质量、客观睡眠持续时间的益处， 和老年人的认知能力。为了实现这些目标，我们将评估睡眠质量、客观睡眠和 认知功能，以及检查接受三个月治疗的参与者的血清 BDNF 水平 补充 NR 或安慰剂。该提案将确认 NR 作为低风险和高风险的潜力。 健康睡眠和优化认知功能的低成本干预。