Research Project 2 - Internal state dynamics of primate perception and decision-making

研究项目2-灵长类感知和决策的内部状态动力学 负责人：埃亚尔·塞德曼博士 项目摘要 RP2的首要目标是了解灵长类初级视觉皮质(V1)的神经回路是如何相互作用的 与其他大脑区域一起，在要求苛刻的视觉辨别任务中产生行为表现。我们 将开发和使用一系列史无前例的同时读写的实验工具 猕猴大脑皮质在多个空间尺度上的神经种群反应。我们的最终目标是发展 并测试了能够解释(1)外部编码的定量和机械计算模型 通过动态V1群体反应的输入(视觉或光遗传)，(2)V1对外部反应的解码 神经群体在关键的下游决策/运动区调节行为的刺激，以及(3) 与波动的内部状态相关的V1活动的自发变化与其相互作用 对刺激编码和解码的影响。我们的实验和计算工作将共同提供 对调节复杂的、自然主义的、感知引导的行为的机制的新见解 NHP大脑。

Research Project 2 - Internal state dynamics of primate perception and decision-making Lead: Eyal Seidemann PhD Project Summary The overarching goal of RP2 is to understand how neural circuits in primate primary visual cortex (V1) interact with other brain regions to give rise to behavioral performance in demanding visual discrimination tasks. We will develop and use an unprecedented array of experimental tools for simultaneously reading and writing neural population responses at multiple spatial scales in behaving macaque cortex. Our end goal is to develop and test quantitative and mechanistic computational models that can account for (1) the encoding of external inputs (visual or optogenetic) by dynamic V1 population responses, (2) the decoding of V1 responses to external stimuli by neural populations in key downstream decision/motor areas that mediate behavior, and (3) the interplay between spontaneous variations in V1 activity that are related to fluctuating internal states and their impact on stimulus encoding and decoding. Together, our experimental and computational work will provide novel insights into the mechanisms that mediate complex, naturalistic, perceptually guided behaviors in the NHP brain.