Research and Capacity Building in Antimicrobial Resistance in West Africa

摘要 抗菌素耐药性（AMR）被世界卫生组织认为是 人类健康面临的最大全球威胁，并限制了实现 可持续发展目标，特别是可持续发展目标3（确保健康生活和促进福祉） 所有年龄段的人）。尽管AMR的负担不成比例地影响着撒哈拉以南的西部地区， 在非洲，该次区域的研究能力非常低，无法很好地解决目前的问题。 问题的要求。西非在关键领域严重缺乏专业人员， 这些领域对影响研究、政策和疾病控制至关重要。有一个缺乏 与AMR相关的一系列关键专业知识，如基因组学、生物信息学 和其他非洲地区相比。这些研究能力的不足 可以通过注重对当地年轻科学家的长期机构培训来解决。 然而，目前西非国家几乎没有任何学术培训项目， 关注AMR。拟议培训方案的目标是增加对 在西非检测、预防和治疗耐药感染， 和临床微生物学技能，并帮助年轻科学家在AMR中找到可行的职业道路 research.长期目标是建立一个西非科学家核心， 了解和管理AMR，并支持他们在获得 来自国际资助机构的研究赠款，如美国国立卫生研究院 The Wellcome Trust，英国

ABSTRACT Antimicrobial resistance (AMR) is considered by the World Health Organization as one of the greatest global threats to human health in recent times and limits achievement of several of the Sustainable Development goals, in particular SDG3 (Ensure healthy lives and promote well-being for all at all ages). Although the burden of AMR disproportionately affects western sub-Saharan Africa, research capacity in the sub-region is very low and not well positioned to tackle the current demands of the problem. There is an acute shortage of professionals in West Africa in crucial areas that are essential to impact research, policy and disease control. There is a dearth of expertise for an array of crucial specialization relevant to AMR such as genomics, bioinformatics and population genetics compared to other African regions. These research capacity deficiencies could be addressed by focusing on long-term institutional training of junior scientists locally. However, currently, there are hardly any academic training programs in West Africa countries that focus on AMR. The objective of the proposed training programme is to increase research into the detection, prevention and treatment of drug-resistant infections in West Africa, expand knowledge and skills in clinical microbiology, and help junior scientists find a viable career path in AMR research. The long-term goal is to establish a core of West African scientists who advance the understanding and management of AMR and to support them to be competitive in obtaining research grants from international funding agencies such as the National Institutes of Health, USA and The Wellcome Trust, UK.