Long COVID as a putative subtype of chronic fatigue syndrome

长期新冠肺炎是慢性疲劳综合症的一种推定亚型

基本信息

  • 批准号:
    10686215
  • 负责人:
  • 金额:
    $ 35.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-18 至 2027-07-31
  • 项目状态:
    未结题

项目摘要

Abstract A hallmark of infection with SARS-CoV-2 is the unpredictable variation in individual health response from those who are asymptomatic to those with life-threatening and refractory respiratory illness, and finally those with long lasting symptoms, here defined as Long COVID. The core symptoms of Long COVID are remarkably like chronic fatigue syndrome (CFS) with multisystem complaints including debilitating fatigue, fluctuating heart rate and headache. In CFS, an infectious trigger has been suspected but not proven and onset often follows flu-like symptoms. As disease mechanisms are not understood, the treatment options are currently symptomatic. Between 0.2-0.4% of the population suffer from CFS. The goal of this proposal is to elucidate the biological mechanisms and risk factors for Long COVID and test the hypothesis that Long COVID is a subtype of chronic fatigue syndrome. To elucidate potential mechanisms, we will use data from three different biobanks, a Long COVID genetics working group we have built and through a CFS consortium. In Aim 1, we will examine genetic risk factors and comorbidities through the Long COVID working group comprising 46 cohorts and over 1.5 million individuals. In addition, we will do a meta-analysis of CFS across three Biobanks (N = 740,000). This analysis will elucidate the connection between CFS and Long COVID and identify risk variants for both diseases. In Aim 2, we will explore contribution from immune molecules that fine tune response to pathogens. The immune defense relies on specific cells to prevent infection or to destroy viral and bacterial agents and the body's own infected cells alike. This aim will examine if the genetic variants that protect from infections, COVID-19, or comorbidities, predispose to Long COVID. We will specifically focus on those regions that have large explanatory power such as the human leukocyte antigen (HLA) in addition to exploring associations genome-wide at established COVID-19 loci. This aim will reveal which immune traits increase risk or protect from Long COVID and CFS, elucidating the type of immune responses responsible for disease development. In Aim 3, we will estimate heritability and shared genetic vs. environmental risk. We will estimate the proportion of environmental and genetic factors behind CFS and Long COVID through analysis of siblings, twins, and the general population in FinnGen and UK Biobank. This aim distinguishes the risk contribution from environmental risk and genetics in the context of a shared environment providing insight into the strength of shared environmental vs. genetic factors that are needed for disease development. The proposed work elucidates risk factors and comorbidities that contribute to CFS and Long COVID including the possibly shared disease etiology, symptomatology, and comorbidity. The project provides biological insights for future disease treatment and facilitates early disease diagnosis.
摘要

项目成果

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RICHA SAXENA其他文献

RICHA SAXENA的其他文献

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{{ truncateString('RICHA SAXENA', 18)}}的其他基金

Integrative omics of preeclampsia in TOPMED and maternal cardiovascular health
TOPMED 中子痫前期的综合组学和孕产妇心血管健康
  • 批准号:
    10418036
  • 财政年份:
    2022
  • 资助金额:
    $ 35.32万
  • 项目类别:
Integrative omics of preeclampsia in TOPMED and maternal cardiovascular health
TOPMED 中子痫前期的综合组学和孕产妇心血管健康
  • 批准号:
    10604382
  • 财政年份:
    2022
  • 资助金额:
    $ 35.32万
  • 项目类别:
Genetics of chronotype and impact on metabolic disease
时间型遗传学及其对代谢疾病的影响
  • 批准号:
    9176615
  • 财政年份:
    2016
  • 资助金额:
    $ 35.32万
  • 项目类别:
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes
褪黑激素和受体基因变异:昼夜节律系统与 2 型糖尿病的联系
  • 批准号:
    9129655
  • 财政年份:
    2015
  • 资助金额:
    $ 35.32万
  • 项目类别:
Discovery of genes for sleep traits
发现睡眠特征基因
  • 批准号:
    8902257
  • 财政年份:
    2014
  • 资助金额:
    $ 35.32万
  • 项目类别:
Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
MTNR1B 和 CRY2 变异对睡眠昼夜节律生理和代谢的影响
  • 批准号:
    7976592
  • 财政年份:
    2010
  • 资助金额:
    $ 35.32万
  • 项目类别:
Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
MTNR1B 和 CRY2 变异对睡眠昼夜节律生理和代谢的影响
  • 批准号:
    8139804
  • 财政年份:
    2010
  • 资助金额:
    $ 35.32万
  • 项目类别:
Mitochondrial Variation and risk of T2DM
线粒体变异和 T2DM 风险
  • 批准号:
    6924607
  • 财政年份:
    2004
  • 资助金额:
    $ 35.32万
  • 项目类别:
Mitochondrial Variation and risk of T2DM
线粒体变异和 T2DM 风险
  • 批准号:
    6791954
  • 财政年份:
    2004
  • 资助金额:
    $ 35.32万
  • 项目类别:

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